Y
Ying Lin
Researcher at University of Electronic Science and Technology of China
Publications - 44
Citations - 1986
Ying Lin is an academic researcher from University of Electronic Science and Technology of China. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 19, co-authored 44 publications receiving 1742 citations. Previous affiliations of Ying Lin include Peking Union Medical College & University of California, San Diego.
Papers
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Journal ArticleDOI
Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,J. Jefferson,P. Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +42 more
TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.
Journal ArticleDOI
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
Hong Ouyang,Yuanchao Xue,Ying Lin,Xiaohui Zhang,Lei Xi,Sherrina Patel,Huimin Cai,Jing Luo,Meixia Zhang,Ming Zhang,Yang Yang,Gen Li,Hairi Li,Wei Jiang,Emily Yeh,Jonathan H. Lin,Michelle Pei,Jin Zhu,Guiqun Cao,Liangfang Zhang,Benjamin D. Yu,Shaochen Chen,Xiang-Dong Fu,Yizhi Liu,Kang Zhang +24 more
TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.
Journal ArticleDOI
Exome sequencing identifies ZNF644 mutations in high myopia.
Yi Shi,Yingrui Li,Dingding Zhang,Hao Zhang,Yuanfeng Li,Fang Lu,Xiaoqi Liu,Fei He,Bo Gong,Li Cai,Ruiqiang Li,Shihuang Liao,Shi Ma,He Lin,Jing Cheng,Hancheng Zheng,Ying Shan,Bin Chen,Jianbin Hu,Xin Jin,Peiquan Zhao,Y W Chen,Yong Zhang,Ying Lin,Xi Li,Fan Y,Huanming Yang,Jun Wang,Zhenglin Yang +28 more
TL;DR: A successful application of exome sequencing is shown to identify a gene for an autosomal dominant disorder, and a gene potentially responsible for high myopia in a monogenic form is identified.
Journal ArticleDOI
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
Yuhong Chen,Ying Lin,Eranga N. Vithana,Liyun Jia,Xianbo Zuo,Tien Yin Wong,Li Jia Chen,Xianjun Zhu,Pancy O. S. Tam,Bo Gong,Shaohong Qian,Zheng Li,Xiaoqi Liu,Baskaran Mani,Qian Luo,Celeste Guzman,Christopher Kai-Shun Leung,Xiaobo Li,Wenjun Cao,Quanyao Yang,Clement C Y Tham,Yilian Cheng,Xuejun Zhang,Ningli Wang,Tin Aung,Chiea Chuen Khor,Chi Pui Pang,Xinghuai Sun,Zhenglin Yang +28 more
TL;DR: Both ABCA1 and PMM2 are expressed in the trabecular meshwork, optic nerve and other ocular tissues, a finding consistent with it having a role in the development of glaucoma.
Journal ArticleDOI
New loci and coding variants confer risk for age-related macular degeneration in East Asians
Ching-Yu Cheng,Kenji Yamashiro,Li Jia Chen,Jeeyun Ahn,Lulin Huang,Lvzhen Huang,Chui Ming Gemmy Cheung,Masahiro Miyake,Peter Cackett,Ian Yeo,Augustinus Laude,Ranjana Mathur,Junxiong Pang,Kar Seng Sim,Adrian Koh,Peng Chen,Shu Yen Lee,Doric Wong,Choi Mun Chan,Boon Kwang Loh,Yaoyao Sun,Sonia Davila,Isao Nakata,Hideo Nakanishi,Yumiko Akagi-Kurashige,Norimoto Gotoh,Akitaka Tsujikawa,Fumihiko Matsuda,Keisuke Mori,Shin Yoneya,Yoichi Sakurada,Hiroyuki Iijima,Tomohiro Iida,Shigeru Honda,Timothy Y Y Lai,Pancy O. S. Tam,Haoyu Chen,Shibo Tang,Xiaoyan Ding,Feng Wen,Fang Lu,Xiongze Zhang,Yi Shi,Peiquan Zhao,Bowen Zhao,Jinghong Sang,Bo Gong,Rajkumar Dorajoo,Jian-Min Yuan,Woon-Puay Koh,Rob M. van Dam,Yechiel Friedlander,Ying Lin,Martin L. Hibberd,Jia Nee Foo,Ningli Wang,Chang Hua Wong,Gavin Tan,Sang Jun Park,Mayuri Bhargava,Lingam Gopal,Thet Naing,Jiemin Liao,Peng Guan Ong,Paul Mitchell,Peng Zhou,Xuefeng Xie,Jinlong Liang,Junpu Mei,Xin Jin,Seang-Mei Saw,Mineo Ozaki,Takanori Mizoguchi,Yasuo Kurimoto,Se Joon Woo,Hum Chung,Hyeong Gon Yu,Joo Young Shin,Dong Ho Park,In Taek Kim,Woohyok Chang,Min Sagong,Sang Joon Lee,Hyun Woong Kim,Ji Eun Lee,Yi Li,Jianjun Liu,Yik Ying Teo,Chew-Kiat Heng,Tock Han Lim,Suk-Kyun Yang,Kyuyoung Song,Eranga N. Vithana,Tin Aung,Jin Xin Bei,Yi Xin Zeng,E. Shyong Tai,Xiaoxin Li,Zhenglin Yang,Kyu Hyung Park,Chi Pui Pang,Nagahisa Yoshimura,Tien Yin Wong,Chiea Chuen Khor +103 more
TL;DR: The findings suggest that some of the genetic loci conferring AMD susceptibility in East Asians are shared with Europeans, yet AMD in East Asia may also have a distinct genetic signature.