Institution
Aix-Marseille University
Education•Marseille, France•
About: Aix-Marseille University is a education organization based out in Marseille, France. It is known for research contribution in the topics: Population & Galaxy. The organization has 24326 authors who have published 54240 publications receiving 1455416 citations. The organization is also known as: University Aix-Marseille & université d'Aix-Marseille.
Topics: Population, Galaxy, Context (language use), Redshift, Medicine
Papers published on a yearly basis
Papers
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TL;DR: Hydroxychloroquine did not confer protection against SARS-CoV-2 infection or reduce the viral load after infection in macaques; these findings do not support the use of hydroxy chloroquine as an antiviral drug treatment of COVID-19 in humans.
Abstract: Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs that have demonstrated antiviral efficacy in vitro. Among these candidates, hydroxychloroquine (HCQ) has been given to thousands of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-the virus that causes COVID-19-worldwide but there is no definitive evidence that HCQ is effective for treating COVID-194-7. Here we evaluated the antiviral activity of HCQ both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in African green monkey kidney cells (Vero E6) but not in a model of reconstituted human airway epithelium. In macaques, we tested different treatment strategies in comparison to a placebo treatment, before and after peak viral load, alone or in combination with azithromycin (AZTH). Neither HCQ nor the combination of HCQ and AZTH showed a significant effect on viral load in any of the analysed tissues. When the drug was used as a pre-exposure prophylaxis treatment, HCQ did not confer protection against infection with SARS-CoV-2. Our findings do not support the use of HCQ, either alone or in combination with AZTH, as an antiviral drug for the treatment of COVID-19 in humans.
278 citations
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Harvard University1, Mayo Clinic2, Humboldt University of Berlin3, University of Münster4, Aix-Marseille University5, University of Virginia6, University of Calgary7, Erasmus University Rotterdam8, German Cancer Research Center9, University Hospital Heidelberg10, VU University Amsterdam11, Utrecht University12
TL;DR: cIMPACT Working Committee 3 clarified diagnostic criteria for the following entities: Diffuse midline glioma, H3 K27M-mutant; diffuse astrocytoma, IDH-mutants; and anaplastic astro Cystic Tumor Taxonomy, ID hmutant.
Abstract: The major changes in brain tumor classification arise through the World Health Organization (WHO) classification update process. To provide possible guidelines for practicing diagnosticians between WHO updates and to facilitate future WHO classification updates, cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy—Not Official WHO) was established. Since its creation in 2016, cIMPACT-NOW (cIMPACT for short) has convened three working committees to address ongoing classification and grading challenges. In addition to addressing questions about the use of the NOS (Not Otherwise Specified) suffix, Working Committee 3 clarified diagnostic criteria for the following entities: Diffuse midline glioma, H3 K27M-mutant; diffuse astrocytoma, IDH-mutant; and anaplastic astrocytoma, IDH-mutant. The present correspondence reports the recommendations of cIMPACT Working Committee 3 clarifying diagnostic criteria for these entities.
277 citations
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TL;DR: It is shown how the time courses of the scalp potentials mis-estimate the latencies of the relevant brain events and that CSD provides a much richer, and much more accurate, view of the spatio-temporal dynamics of brain activity.
277 citations
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TL;DR: In this article, the authors studied the symmetry properties of non-local boundary reaction equations and derived a geometric formula of Poincare-type for stable solutions, from which they derived a symmetry result in the spirit of a conjecture of De Giorgi.
276 citations
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University of Bern1, Southwest Research Institute2, Tel Aviv University3, Versailles Saint-Quentin-en-Yvelines University4, University of Michigan5, University of Orléans6, Belgian Institute for Space Aeronomy7, Katholieke Universiteit Leuven8, Braunschweig University of Technology9, Imperial College London10, German Aerospace Center11, Max Planck Society12, Aix-Marseille University13, University of Hawaii14, Hoffmann-La Roche15, University of Toulouse16
TL;DR: Rosetta Orbiter Spectrometer for Ion and Neutral Analysis onboard the Rosetta spacecraft has measured the coma composition of comet 67P/Churyumov-Gerasimenko with well-sampled time resolution per rotation, indicating a complex coma-nucleus relationship.
Abstract: Comets contain the best-preserved material from the beginning of our planetary system. Their nuclei and comae composition reveal clues about physical and chemical conditions during the early solar system when comets formed. ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) onboard the Rosetta spacecraft has measured the coma composition of comet 67P/Churyumov-Gerasimenko with well-sampled time resolution per rotation. Measurements were made over many comet rotation periods and a wide range of latitudes. These measurements show large fluctuations in composition in a heterogeneous coma that has diurnal and possibly seasonal variations in the major outgassing species: water, carbon monoxide, and carbon dioxide. These results indicate a complex coma-nucleus relationship where seasonal variations may be driven by temperature differences just below the comet surface.
276 citations
Authors
Showing all 24784 results
Name | H-index | Papers | Citations |
---|---|---|---|
Didier Raoult | 173 | 3267 | 153016 |
Andrea Bocci | 172 | 2402 | 176461 |
Marc Humbert | 149 | 1184 | 100577 |
Carlo Rovelli | 146 | 1502 | 103550 |
Marc Besancon | 143 | 1799 | 106869 |
Jian Yang | 142 | 1818 | 111166 |
Josh Moss | 139 | 1019 | 89255 |
Maksym Titov | 139 | 1573 | 128335 |
Bernard Henrissat | 139 | 593 | 100002 |
R. D. Kass | 138 | 1920 | 107907 |
Stylianos E. Antonarakis | 138 | 746 | 93605 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Brad Abbott | 137 | 1566 | 98604 |
Shu Li | 136 | 1001 | 78390 |
Georges Aad | 135 | 1121 | 88811 |