Institution
Aix-Marseille University
Education•Marseille, France•
About: Aix-Marseille University is a education organization based out in Marseille, France. It is known for research contribution in the topics: Population & Galaxy. The organization has 24326 authors who have published 54240 publications receiving 1455416 citations. The organization is also known as: University Aix-Marseille & université d'Aix-Marseille.
Topics: Population, Galaxy, Context (language use), Redshift, Medicine
Papers published on a yearly basis
Papers
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Lawrence Berkeley National Laboratory1, University of Zurich2, Stanford University3, College of William & Mary4, University of Genoa5, University of Urbino6, CERN7, Budker Institute of Nuclear Physics8, Cornell University9, Argonne National Laboratory10, ETH Zurich11, Tata Institute of Fundamental Research12, Hillsdale College13, Spanish National Research Council14, Tohoku University15, Ohio State University16, University of California, San Diego17, University of California, Berkeley18, Aix-Marseille University19, University of Minnesota20, University of Alabama21, University of Helsinki22, California Institute of Technology23, George Washington University24, University of Kansas25, RWTH Aachen University26, Boston University27, University of California, Los Angeles28, Institut des Hautes Études Scientifiques29, University of Pennsylvania30, University of Tokyo31, University of Delaware32, Fermilab33, Carnegie Mellon University34, University of California, Santa Cruz35, Lawrence Livermore National Laboratory36, University of Washington37, Karlsruhe Institute of Technology38, Heidelberg University39, Florida State University40, Carleton University41, National Science Foundation42, University of Mainz43, University of Edinburgh44, University of Chicago45, Brookhaven National Laboratory46, Kent State University47, Paul Scherrer Institute48, Max Planck Society49, Massachusetts Institute of Technology50, Nagoya University51, Harvard University52
TL;DR: In this article, a biennial review summarizes much of particle physics using data from previous editions., plus 2778 new measurements from 645 papers, including measurements of gauge bosons, leptons, quarks, mesons, and baryons.
Abstract: This biennial Review summarizes much of particle physics. Using data from previous editions., plus 2778 new measurements from 645 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors., probability, and statistics. Among the 108 reviews are many that are new or heavily revised including those on CKM quark-mixing matrix, V-ud & V-us, V-cb & V-ub, top quark, muon anomalous magnetic moment, extra dimensions, particle detectors, cosmic background radiation, dark matter, cosmological parameters, and big bang cosmology.
1,520 citations
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University of Sydney1, National and Kapodistrian University of Athens2, The Royal Marsden NHS Foundation Trust3, University of Tübingen4, University of Duisburg-Essen5, University of Kiel6, Aix-Marseille University7, University of Paris8, University of Barcelona9, Netherlands Cancer Institute10, Karolinska Institutet11, Heidelberg University12, Mount Vernon Hospital13, Institut Gustave Roussy14, University of California, Los Angeles15, GlaxoSmithKline16, Harvard University17
TL;DR: A combination of dabraenib and trametinib, as compared with dabrafenib alone, improved the rate of progression-free survival in previously untreated patients who had metastatic melanoma with BRAF V600E or V600K mutations.
Abstract: BACKGROUND Combined BRAF and MEK inhibition, as compared with BRAF inhibition alone, delays the emergence of resistance and reduces toxic effects in patients who have melanoma with BRAF V600E or V600K mutations. METHODS In this phase 3 trial, we randomly assigned 423 previously untreated patients who had unresectable stage IIIC or stage IV melanoma with a BRAF V600E or V600K mutation to receive a combination of dabrafenib (150 mg orally twice daily) and trametinib (2 mg orally once daily) or dabrafenib and placebo. The primary end point was progression-free survival. Secondary end points included overall survival, response rate, response duration, and safety. A preplanned interim overall survival analysis was conducted. RESULTS The median progression-free survival was 9.3 months in the dabrafenib–trametinib group and 8.8 months in the dabrafenib-only group (hazard ratio for progression or death in the dabrafenib–trametinib group, 0.75; 95% confidence interval [CI], 0.57 to 0.99; P = 0.03). The overall response rate was 67% in the dabrafenib–trametinib group and 51% in the dabrafenib-only group (P = 0.002). At 6 months, the interim overall survival rate was 93% with dabrafenib–trametinib and 85% with dabrafenib alone (hazard ratio for death, 0.63; 95% CI, 0.42 to 0.94; P = 0.02). However, a specified efficacy-stopping boundary (two-sided P = 0.00028) was not crossed. Rates of adverse events were similar in the two groups, although more dose modifications occurred in the dabrafenib–trametinib group. The rate of cutaneous squamous-cell carcinoma was lower in the dabrafenib–trametinib group than in the dabrafenib-only group (2% vs. 9%), whereas pyrexia occurred in more patients (51% vs. 28%) and was more often severe (grade 3, 6% vs. 2%) in the dabrafenib–trametinib group. CONCLUSIONS A combination of dabrafenib and trametinib, as compared with dabrafenib alone, improved the rate of progression-free survival in previously untreated patients who had metastatic melanoma with BRAF V600E or V600K mutations. (Funded by GlaxoSmithKline; Clinical Trials.gov number, NCT01584648.)
1,501 citations
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TL;DR: This review is based on presentations at the annual INMED/TINS symposium, Physiogenic and pathogenic oscillations: the beauty and the beast, based on work using tissue slice preparations, animal models and in humans with Parkinson's disease.
1,489 citations
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TL;DR: The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide as discussed by the authors.
Abstract: The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide. In the absence of calcium/calmodulin, eNOS produces low amounts of superoxide. Upon activating eNOS electron transfer reactions by calcium/calmodulin binding, superoxide formation is increased. Heme-iron ligands, cyanide, imidazole, and the phenyl(diazene)-derived radical inhibit superoxide generation. No inhibition is observed after addition of l-arginine, NG-hydroxy-l-arginine, l-thiocitrulline, and l-NG-monomethyl arginine to activated eNOS. These results demonstrate that superoxide is generated from the oxygenase domain by dissociation of the ferrous–dioxygen complex and that occupation of the l-arginine binding site does not inhibit this process. However, the concomitant addition of l-arginine and tetrahydrobiopterin (BH4) abolishes superoxide generation by eNOS. Under these conditions, l-citrulline production is close to maximal. Our data indicate that BH4 fully couples l-arginine oxidation to NADPH consumption and prevents dissociation of the ferrous–dioxygen complex. Under these conditions, eNOS does not generate superoxide. The presence of flavins, at concentrations commonly employed in NOS assay systems, enhances superoxide generation from the reductase domain. Our data indicate that modulation of BH4 concentration may regulate the ratio of superoxide to nitric oxide generated by eNOS.
1,433 citations
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TL;DR: A peculiar furin-like cleavage site is identified in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs, and its potential implication in the development of antivirals is discussed.
1,427 citations
Authors
Showing all 24784 results
Name | H-index | Papers | Citations |
---|---|---|---|
Didier Raoult | 173 | 3267 | 153016 |
Andrea Bocci | 172 | 2402 | 176461 |
Marc Humbert | 149 | 1184 | 100577 |
Carlo Rovelli | 146 | 1502 | 103550 |
Marc Besancon | 143 | 1799 | 106869 |
Jian Yang | 142 | 1818 | 111166 |
Josh Moss | 139 | 1019 | 89255 |
Maksym Titov | 139 | 1573 | 128335 |
Bernard Henrissat | 139 | 593 | 100002 |
R. D. Kass | 138 | 1920 | 107907 |
Stylianos E. Antonarakis | 138 | 746 | 93605 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Brad Abbott | 137 | 1566 | 98604 |
Shu Li | 136 | 1001 | 78390 |
Georges Aad | 135 | 1121 | 88811 |