Institution
Aix-Marseille University
Education•Marseille, France•
About: Aix-Marseille University is a education organization based out in Marseille, France. It is known for research contribution in the topics: Population & Galaxy. The organization has 24326 authors who have published 54240 publications receiving 1455416 citations. The organization is also known as: University Aix-Marseille & université d'Aix-Marseille.
Topics: Population, Galaxy, Context (language use), Redshift, Medicine
Papers published on a yearly basis
Papers
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TL;DR: Evidence is provided that a synthetic derivative of salinomycin, which is named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes.
Abstract: Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a selective agent against CSCs through mechanisms that remain elusive. Here, we provide evidence that a synthetic derivative of salinomycin, which we named ironomycin (AM5), exhibits a more potent and selective activity against breast CSCs in vitro and in vivo, by accumulating and sequestering iron in lysosomes. In response to the ensuing cytoplasmic depletion of iron, cells triggered the degradation of ferritin in lysosomes, leading to further iron loading in this organelle. Iron-mediated production of reactive oxygen species promoted lysosomal membrane permeabilization, activating a cell death pathway consistent with ferroptosis. These findings reveal the prevalence of iron homeostasis in breast CSCs, pointing towards iron and iron-mediated processes as potential targets against these cells.
354 citations
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Wright-Patterson Air Force Base1, Vanderbilt University2, University of Manchester3, University of Cambridge4, Lawrence Livermore National Laboratory5, University of Southern California6, Massachusetts Institute of Technology7, Kansas State University8, Yale University9, Rice University10, Texas A&M University11, Aix-Marseille University12, National Institute of Advanced Industrial Science and Technology13, Waseda University14, National Research Council15, Aalto University16, University of Wisconsin-Madison17, Georgia Institute of Technology18, Tsinghua University19, Brookhaven National Laboratory20, University of Pennsylvania21, Peking University22, Pennsylvania State University23, Oak Ridge National Laboratory24, University of Tokyo25
TL;DR: While the primary focus of this review is on the science framework of SWCNT growth, connections to mechanisms underlying the synthesis of other 1D and 2D materials such as boron nitride nanotubes and graphene are drawn.
Abstract: Advances in the synthesis and scalable manufacturing of single-walled carbon nanotubes (SWCNTs) remain critical to realizing many important commercial applications. Here we review recent breakthroughs in the synthesis of SWCNTs and highlight key ongoing research areas and challenges. A few key applications that capitalize on the properties of SWCNTs are also reviewed with respect to the recent synthesis breakthroughs and ways in which synthesis science can enable advances in these applications. While the primary focus of this review is on the science framework of SWCNT growth, we draw connections to mechanisms underlying the synthesis of other 1D and 2D materials such as boron nitride nanotubes and graphene.
354 citations
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Columbia University1, California Institute of Technology2, Aix-Marseille University3, Johns Hopkins University4, University of Bologna5, INAF6, Yonsei University7, Max Planck Society8, Brera Astronomical Observatory9, University of California, Berkeley10, Carnegie Institution for Science11, Institut d'Astrophysique de Paris12, Goddard Space Flight Center13, University of California, Los Angeles14, National Research Council15
TL;DR: Arnouts et al. as discussed by the authors used the same sample to study evolution of the FUV luminosity density, and they detected evolution consistent with a (1+z)^{2.5+/-0.7} rise to z~1.
Abstract: In a companion paper (Arnouts et al. 2004) we presented new measurements of the galaxy luminosity function at 1500 Angstroms out to z~1 using GALEX-VVDS observations (1039 galaxies with NUV 0.2) and at higher z using existing data sets. In this paper we use the same sample to study evolution of the FUV luminosity density. We detect evolution consistent with a (1+z)^{2.5+/-0.7} rise to z~1 and (1+z)^{0.5+/-0.4} for z>1. The luminosity density from the most UV-luminous galaxies (UVLG) is undergoing dramatic evolution (x30) between 025%) of the total FUV luminosity density at z<1. We measure dust attenuation and star formation rates of our sample galaxies and determine the star formation rate density as a function of redshift, both uncorrected and corrected for dust. We find good agreement with other measures of the SFR density in the rest ultraviolet and Halpha given the still significant uncertainties in the attenuation correction.
353 citations
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University of Bonn1, Maastricht University Medical Centre2, University of Lausanne3, Erasmus University Rotterdam4, Heidelberg University5, European Organisation for Research and Treatment of Cancer6, University of Paris7, Academy for Urban School Leadership8, Leiden University9, Hochschule Hannover10, Peter MacCallum Cancer Centre11, Australian National University12, University of Groningen13, BC Cancer Agency14, Institut Gustave Roussy15, VU University Medical Center16, Aix-Marseille University17, Radboud University Nijmegen18, Queen's University19, Instituto Português de Oncologia Francisco Gentil20, Katholieke Universiteit Leuven21, Medical University of Vienna22, Rambam Health Care Campus23, University of Calgary24, University of Kent25, University of Toronto26, University of Zurich27
TL;DR: There was no significant difference in outcome of the overall patient population treated with either radiotherapy alone or TMZ chemotherapy alone, and further data maturation is needed for overall survival analyses and evaluation of the full predictive impact of the molecular subtypes for individualized treatment choices.
Abstract: Summary Background Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors. Methods For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50·4 Gy; 28 doses of 1·8 Gy once daily, 5 days per week for up to 6·5 weeks) or dose-dense oral temozolomide (75 mg/m 2 once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age ( vs ≥40 years), and WHO performance status (0 vs ≥1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of progression-free survival by molecular markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/IDH2 mutations). This trial is closed to accrual but continuing for follow-up, and is registered at the European Trials Registry, EudraCT 2004-002714-11, and at ClinicalTrials.gov, NCT00182819. Findings Between Sept 23, 2005, and March 26, 2010, 707 patients were registered for the study. Between Dec 6, 2005, and Dec 21, 2012, we randomly assigned 477 patients to receive either radiotherapy (n=240) or temozolomide chemotherapy (n=237). At a median follow-up of 48 months (IQR 31–56), median progression-free survival was 39 months (95% CI 35–44) in the temozolomide group and 46 months (40–56) in the radiotherapy group (unadjusted hazard ratio [HR] 1·16, 95% CI 0·9–1·5, p=0·22). Median overall survival has not been reached. Exploratory analyses in 318 molecularly-defined patients confirmed the significantly different prognosis for progression-free survival in the three recently defined molecular low-grade glioma subgroups ( IDH mt, with or without 1p/19q co-deletion [ IDH mt/codel], or IDH wild type [ IDH wt]; p=0·013). Patients with IDH mt/non-codel tumours treated with radiotherapy had a longer progression-free survival than those treated with temozolomide (HR 1·86 [95% CI 1·21–2·87], log-rank p=0·0043), whereas there were no significant treatment-dependent differences in progression-free survival for patients with IDH mt/codel and IDH wt tumours. Grade 3–4 haematological adverse events occurred in 32 (14%) of 236 patients treated with temozolomide and in one ( Interpretation Overall, there was no significant difference in progression-free survival in patients with low-grade glioma when treated with either radiotherapy alone or temozolomide chemotherapy alone. Further data maturation is needed for overall survival analyses and evaluation of the full predictive effects of different molecular subtypes for future individualised treatment choices. Funding Merck Sharpe & Dohme-Merck & Co, Canadian Cancer Society, Swiss Cancer League, UK National Institutes of Health, Australian National Health and Medical Research Council, US National Cancer Institute, European Organisation for Research and Treatment of Cancer Cancer Research Fund.
353 citations
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TL;DR: Simple expressions of dimensionless parameters aimed at predicting the degree of temperature confinement and analytical expressions aimed at estimating the actual temperature increase at the center of an assembly of nanoparticles under illumination are derived, preventing heavy numerical simulations.
Abstract: The temperature distribution throughout arrays of illuminated metal nanoparticles is investigated numerically and experimentally. The two cases of continuous and femtosecond-pulsed illumination are addressed. In the case of continuous illumination, two distinct regimes are evidenced: a temperature confinement regime, where the temperature increase remains confined at the vicinity of each nanosource of heat, and a temperature delocalization regime, where the temperature is uniform throughout the whole nanoparticle assembly despite the heat sources’ nanometric size. We show that the occurrence of one regime or another simply depends on the geometry of the nanoparticle distribution. In particular, we derived (i) simple expressions of dimensionless parameters aimed at predicting the degree of temperature confinement and (ii) analytical expressions aimed at estimating the actual temperature increase at the center of an assembly of nanoparticles under illumination, preventing heavy numerical simulations. All th...
352 citations
Authors
Showing all 24784 results
Name | H-index | Papers | Citations |
---|---|---|---|
Didier Raoult | 173 | 3267 | 153016 |
Andrea Bocci | 172 | 2402 | 176461 |
Marc Humbert | 149 | 1184 | 100577 |
Carlo Rovelli | 146 | 1502 | 103550 |
Marc Besancon | 143 | 1799 | 106869 |
Jian Yang | 142 | 1818 | 111166 |
Josh Moss | 139 | 1019 | 89255 |
Maksym Titov | 139 | 1573 | 128335 |
Bernard Henrissat | 139 | 593 | 100002 |
R. D. Kass | 138 | 1920 | 107907 |
Stylianos E. Antonarakis | 138 | 746 | 93605 |
Jean-Paul Kneib | 138 | 805 | 89287 |
Brad Abbott | 137 | 1566 | 98604 |
Shu Li | 136 | 1001 | 78390 |
Georges Aad | 135 | 1121 | 88811 |