Aix-Marseille University

About: Aix-Marseille University is a education organization based out in Marseille, France. It is known for research contribution in the topics: Population & Galaxy. The organization has 24326 authors who have published 54240 publications receiving 1455416 citations. The organization is also known as: University Aix-Marseille & université d'Aix-Marseille.

Planck 2015 results: XXVI. The Second Planck Catalogue of Compact Sources

Abstract: The Second Planck Catalogue of Compact Sources is a list of discrete objects detected in single-frequency maps from the full duration of the Planck mission and supersedes previous versions. It consists of compact sources, both Galactic and extragalactic, detected over the entire sky. Compact sources detected in the lower frequency channels are assigned to the PCCS2, while at higher frequencies they are assigned to one of two subcatalogues, the PCCS2 or PCCS2E, depending on their location on the sky. The first of these (PCCS2) covers most of the sky and allows the user to produce subsamples at higher reliabilities than the target 80% integral reliability of the catalogue. The second (PCCS2E) contains sources detected in sky regions where the diffuse emission makes it difficult to quantify the reliability of the detections. Both the PCCS2 and PCCS2E include polarization measurements, in the form of polarized flux densities, or upper limits, and orientation angles for all seven polarization-sensitive Planck channels. The improved data-processing of the full-mission maps and their reduced noise levels allow us to increase the number of objects in the catalogue, improving its completeness for the target 80% reliability as compared with the previous versions, the PCCS and the Early Release Compact Source Catalogue (ERCSC).

High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group

Abstract: Pivotal phase II studies in acute myeloblastic leukemia (AML) patients in first relapse have used gemtuzumab ozogamicin (GO) (Mylotarg) at a dose of 9 mg/m(2) on days 1 and 14. These studies showed a 26% response rate (13% complete remission (CR) and 13% CRp (complete remission with incomplete platelet recovery)) but with high degree of hematological and liver toxicities. Based on in vitro studies showing a re-expression of CD33 antigenic sites on the cell surface of blasts cells after exposure to GO, we hypothesized that fractionated doses of GO may be efficient and better tolerated. Fifty-seven patients with AML in first relapse received GO at a dose of 3 mg/m(2) on days 1, 4 and 7 for one course. Fifteen patients (26%) achieved CR and four (7%) CRp. Remission rate correlated strongly with P-glycoprotein and MRP1 activities. The median relapse-free survival was 11 months, similar for CR or CRp patients. Median duration of neutropenia < 500/microl and thrombocytopenia < 50,000/microl were, respectively, 23 and 21 days. No grade 3 or 4 liver toxicity was observed. No veno-occlusive disease occurred after GO or after hematopoietic stem cell transplantation given after GO in seven patients. Mylotarg administered in fractionated doses demonstrated an excellent efficacy/safety profile.

Taxonomy of the order Bunyavirales : update 2019

Abstract: In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).

GOODS-HERSCHEL: STAR FORMATION, DUST ATTENUATION, AND THE FIR–RADIO CORRELATION ON THE MAIN SEQUENCE OF STAR-FORMING GALAXIES UP TO z ≃ 4*

Abstract: We use the deep panchromatic dataset available in the GOODS-N field, spanning all the way from GALEX ultra-violet to VLA radio continuum data, to select a star-forming galaxy sample at z~[0.5-4] and robustly measure galaxy photometric redshifts, star formation rates, stellar masses and UV rest-frame properties. We quantitatively explore, using mass-complete samples, the evolution of the star formation activity and dust attenuation properties of star-forming galaxies up to z~4. Our main results can be summarized as follows: i) we find that the slope of the SFR-M correlation is consistent with being constant, and equal to ~0.8 at least up to z~1.5, while the normalization keeps increasing to the highest redshift, z~4, we are able to explore; ii) for the first time in this work, we are able to explore the FIR-radio correlation for a mass-selected sample of star-forming galaxies: the correlation does not evolve up to z~4; iii) we confirm that galaxy stellar mass is a robust proxy for UV dust attenuation in star-forming galaxies, with more massive galaxies being more dust attenuated; iv) strikingly, we find that this attenuation relation evolves very weakly with redshift, the amount of dust attenuation increasing by less than 0.3 magnitudes over the redshift range [0.5-4] for a fixed stellar mass, as opposed to a tenfold increase of star formation rate; v) this finding explains the evolution of the SFR-Auv relation reported in literature: the same amount of star formation is less attenuated at higher redshift because it is hosted in less massive, and less metal rich, galaxies; vi) the correlation between dust attenuation and the UV spectral slope evolves in redshift, with the median UV spectral slope of star-forming galaxies becoming bluer with redshift. By z~3, typical UV slopes are inconsistent, given the measured dust attenuation, with the predictions of commonly used empirical laws: this means that the present cosmic star formation rate density estimates at redshift z > 3 need to be increased by a factor of around 2. Finally, building on the measured AUV–logM correlation and on existing results, we find evidence that line reddening is marginally larger (by a factor of around 1.3) than continuum reddening at all redshifts probed, and also that the amount of dust attenuation at a fixed ISM metallicity increases with redshift. We speculate that our results point toward an evolution of the ISM conditions of the median star-forming galaxy, such that at z >1.5, Main Sequence galaxies have ISM properties more similar to those found in local starbursts.