Showing papers by "Auckland University of Technology published in 2019"

Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.

Abstract: Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their relative contributions to determining oxaliplatin tumour responses and gastrointestinal tumour cell sensitivity to oxaliplatin remains unclear. We studied clinical associations between tumour expression of oxaliplatin transporter candidate genes and patient response to oxaliplatin, then experimentally verified associations found with MRP2 in models of human gastrointestinal cancer. Among 18 oxaliplatin transporter candidate genes, MRP2 was the only one to be differentially expressed in the tumours of colorectal cancer patients who did or did not respond to FOLFOX chemotherapy. Over-expression of MRP2 (endogenously in HepG2 and PANC-1 cells, or induced by stable transfection of HEK293 cells) decreased oxaliplatin accumulation and cytotoxicity but those deficits were reversed by inhibition of MRP2 with myricetin or siRNA knockdown. Mice bearing subcutaneous HepG2 tumour xenografts were sensitised to oxaliplatin antitumour activity by concurrent myricetin treatment with little or no increase in toxicity. In conclusion, MRP2 limits oxaliplatin accumulation and response in human gastrointestinal cancer. Screening tumour MRP2 expression levels, to select patients for treatment with oxaliplatin-based chemotherapy alone or in combination with a MRP2 inhibitor, could improve treatment outcomes.

A meta-analysis of 1,119 manipulative experiments on terrestrial carbon-cycling responses to global change

Abstract: Direct quantification of terrestrial biosphere responses to global change is crucial for projections of future climate change in Earth system models. Here, we synthesized ecosystem carbon-cycling data from 1,119 experiments performed over the past four decades concerning changes in temperature, precipitation, CO2 and nitrogen across major terrestrial vegetation types of the world. Most experiments manipulated single rather than multiple global change drivers in temperate ecosystems of the USA, Europe and China. The magnitudes of warming and elevated CO2 treatments were consistent with the ranges of future projections, whereas those of precipitation changes and nitrogen inputs often exceeded the projected ranges. Increases in global change drivers consistently accelerated, but decreased precipitation slowed down carbon-cycle processes. Nonlinear (including synergistic and antagonistic) effects among global change drivers were rare. Belowground carbon allocation responded negatively to increased precipitation and nitrogen addition and positively to decreased precipitation and elevated CO2. The sensitivities of carbon variables to multiple global change drivers depended on the background climate and ecosystem condition, suggesting that Earth system models should be evaluated using site-specific conditions for best uses of this large dataset. Together, this synthesis underscores an urgent need to explore the interactions among multiple global change drivers in underrepresented regions such as semi-arid ecosystems, forests in the tropics and subtropics, and Arctic tundra when forecasting future terrestrial carbon-climate feedback.

World Stroke Organization (WSO): Global Stroke Fact Sheet 2019.

Abstract: Stroke is the second major cause of death and disability worldwide with over 13 million new cases annually. Globally, the overall incidence rates of stroke decreased from 1990 to 2016, largely due to prevention and better control of risk factors such as tobacco use and blood pressure control. Among this decline, the one group that did see an increase is the younger age groups (younger than 50 years) and prevalence rates also increased exponentially since 2005 for this group. However, the absolute number of people who had a stroke, died or remained disabled from stroke has increased from 1990 to 2016 by almost two-fold. The World Stroke Organization (WSO) lead many advocacy efforts through their membership, targeted efforts in lowand middle-income countries, and through the strong voice of Stroke Support Organizations (SSOs). Governments, system leaders, healthcare providers, and the general population need to increase efforts for raising awareness, educating individuals and populations of their risk factors, implementing effective and widely available stroke risk prevention strategies (for example, free Stroke Riskometer app supported by the WSO and already translated into 12 languages) and ensuring timely acute treatments to reduce the long-term burden of stroke. Advocacy efforts require reliable and consistent stroke data to build awareness of the scale of the disease and support for calls for urgent action at global, regional, and national levels. This WSO Global Stroke Fact Sheet 2019 provides information that can be used to inform communication with all internal and external stakeholders; all statistics have been reviewed and approved for use by the WSO Executive Committee as well as leaders from the Global Burden of Disease research group. The facts endorsed by the WSO will be updated every one to two years as new data emerges.

Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men.

Abstract: PurposeThe purpose of this study was to evaluate muscular adaptations between low-, moderate-, and high-volume resistance training protocols in resistance-trained men.MethodsThirty-four healthy resistance-trained men were randomly assigned to one of three experimental groups: a low-volume gr

Modelling carbon sources and sinks in terrestrial vegetation

Abstract: Contents Summary 652 I. Introduction 652 II. Discrepancy in predicting the effects of rising [CO2 ] on the terrestrial C sink 655 III. Carbon and nutrient storage in plants and its modelling 656 IV. Modelling the source and the sink: a plant perspective 657 V. Plant-scale water and Carbon flux models 660 VI. Challenges for the future 662 Acknowledgements 663 Authors contributions 663 References 663 SUMMARY: The increase in atmospheric CO2 in the future is one of the most certain projections in environmental sciences. Understanding whether vegetation carbon assimilation, growth, and changes in vegetation carbon stocks are affected by higher atmospheric CO2 and translating this understanding in mechanistic vegetation models is of utmost importance. This is highlighted by inconsistencies between global-scale studies that attribute terrestrial carbon sinks to CO2 stimulation of gross and net primary production on the one hand, and forest inventories, tree-scale studies, and plant physiological evidence showing a much less pronounced CO2 fertilization effect on the other hand. Here, we review how plant carbon sources and sinks are currently described in terrestrial biosphere models. We highlight an uneven representation of complexity between the modelling of photosynthesis and other processes, such as plant respiration, direct carbon sinks, and carbon allocation, largely driven by available observations. Despite a general lack of data on carbon sink dynamics to drive model improvements, ways forward toward a mechanistic representation of plant carbon sinks are discussed, leveraging on results obtained from plant-scale models and on observations geared toward model developments.

Visible Light Communication: A System Perspective-Overview and Challenges.

Abstract: Visible light communication (VLC) is a new paradigm that could revolutionise the future of wireless communication. In VLC, information is transmitted through modulating the visible light spectrum (400–700 nm) that is used for illumination. Analytical and experimental work has shown the potential of VLC to provide high-speed data communication with the added advantage of improved energy efficiency and communication security/privacy. VLC is still in the early phase of research. There are fewer review articles published on this topic mostly addressing the physical layer research. Unlike other reviews, this article gives a system prespective of VLC along with the survey on existing literature and potential challenges toward the implementation and integration of VLC.

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications.

Abstract: Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

Toward Algorithmic Accountability in Public Services: A Qualitative Study of Affected Community Perspectives on Algorithmic Decision-making in Child Welfare Services

Abstract: Algorithmic decision-making systems are increasingly being adopted by government public service agencies. Researchers, policy experts, and civil rights groups have all voiced concerns that such systems are being deployed without adequate consideration of potential harms, disparate impacts, and public accountability practices. Yet little is known about the concerns of those most likely to be affected by these systems. We report on workshops conducted to learn about the concerns of affected communities in the context of child welfare services. The workshops involved 83 study participants including families involved in the child welfare system, employees of child welfare agencies, and service providers. Our findings indicate that general distrust in the existing system contributes significantly to low comfort in algorithmic decision-making. We identify strategies for improving comfort through greater transparency and improved communication strategies. We discuss the implications of our study for accountable algorithm design for child welfare applications.

A Systematic Review of Wearable Sensors and IoT-Based Monitoring Applications for Older Adults – a Focus on Ageing Population and Independent Living

Abstract: This review aims to present current advancements in wearable technologies and IoT-based applications to support independent living. The secondary aim was to investigate the barriers and challenges of wearable sensors and Internet-of-Things (IoT) monitoring solutions for older adults. For this work, we considered falls and activity of daily life (ADLs) for the ageing population (older adults). A total of 327 articles were screened, and 14 articles were selected for this review. This review considered recent studies published between 2015 and 2019. The research articles were selected based on the inclusion and exclusion criteria, and studies that support or present a vision to provide advancement to the current space of ADLs, independent living and supporting the ageing population. Most studies focused on the system aspects of wearable sensors and IoT monitoring solutions including advanced sensors, wireless data collection, communication platform and usability. Moderate to low usability/ user-friendly approach is reported in most of the studies. Other issues found were inaccurate sensors, battery/ power issues, restricting the users within the monitoring area/ space and lack of interoperability. The advancement of wearable technology and the possibilities of using advanced IoT technology to assist older adults with their ADLs and independent living is the subject of many recent research and investigation.

Editorial: Towards an Understanding of Tinnitus Heterogeneity.

Abstract: Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, Stockholm, Sweden, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy, Nottingham Biomedical Research Centre, National Institute for Health Research, Nottingham, United Kingdom, Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, University of Nottingham Malaysia, Semenyih, Malaysia, Department of Otorhinolaryngology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany, Dipartimento di Giurisprudenza, Economia, Politica e Lingue Moderne, Libera Università Maria SS. Assunta, Rome, Italy, Neuroplasticity

Priorities to reduce the burden of stroke in Latin American countries

Abstract: Summary The large and increasing burden of stroke in Latin American countries, and the need to meet the UN and WHO requirements for reducing the burden from non-communicable disorders (including stroke), brought together stroke experts and representatives of the Ministries of Health of 13 Latin American countries for the 1st Latin American Stroke Ministerial meeting in Gramado, Brazil, to discuss the problem and identify ways of cooperating to reduce the burden of stroke in the region. Discussions were focused on the regional and country-specific activities associated with stroke prevention and treatment, including public stroke awareness, prevention strategies, delivery and organisation of care, clinical practice gaps, and unmet needs. The meeting culminated with the adoption of the special Gramado Declaration, signed by all Ministerial officials who attended the meeting. With agreed priorities for stroke prevention, treatment, and research, an opportunity now exists to translate this Declaration into an action plan to reduce the burden of stroke.

Impact of Job Demands and Resources on Nurses’ Burnout and Occupational Turnover Intention Towards an Age-Moderated Mediation Model for the Nursing Profession

Abstract: This longitudinal study among Registered Nurses has four purposes: (1) to investigate whether emotional, quantitative and physical demands, and family-work conflict have a negative impact on nurses’ perceived effort; (2) to investigate whether quality of leadership, developmental opportunities, and social support from supervisors and colleagues have a positive impact on meaning of work; (3) to investigate whether burnout from the combined impact of perceived effort and meaning of work mediates the relationship with occupational turnover intention; and (4) whether the relationships in our overall hypothesized framework are moderated by age (nurses categorized under 40 years versus ≥ 40 years old). In line with our expectations, emotional, quantitative, and physical demands, plus family-work conflict appeared to increase levels of perceived effort. Quality of leadership, developmental opportunities, and social support from supervisors and colleagues increased the meaning of work levels. In addition, increased perceived stress resulted in higher burnout levels, while increased meaning of work resulted in decreased burnout levels. Finally, higher burnout levels appeared to lead to a higher occupational turnover intention. Obviously, a nursing workforce that is in good physical and psychological condition is only conceivable when health care managers protect the employability of their nursing staff, and when there is a dual responsibility for a sustainable workforce. Additionally, thorough attention for the character of job demands and job resources according to nurses’ age category is necessary in creating meaningful management interventions.

The Accuracy of Acquiring Heart Rate Variability from Portable Devices: A Systematic Review and Meta-Analysis

Abstract: Advancements in wearable technology have provided practitioners and researchers with the ability to conveniently measure various health and/or fitness indices. Specifically, portable devices have been devised for convenient recordings of heart rate variability (HRV). Yet, their accuracies remain questionable. The aim was to quantify the accuracy of portable devices compared to electrocardiography (ECG) for measuring a multitude of HRV metrics and to identify potential moderators of this effect. This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Articles published before July 29, 2017 were located via four electronic databases using a combination of the terms related to HRV and validity. Separate effect sizes (ESs), defined as the absolute standardized difference between the HRV value recorded using the portable device compared to ECG, were generated for each HRV metric (ten metrics analyzed in total). A multivariate, multi-level model, incorporating random-effects assumptions, was utilized to quantify the mean ES and 95% confidence interval (CI) and explore potential moderators. Twenty-three studies yielded 301 effects and revealed that HRV measurements acquired from portable devices differed from those obtained from ECG (ES = 0.23, 95% CI 0.05–0.42), although this effect was small and highly heterogeneous (I2 = 78.6%, 95% CI 76.2–80.7). Moderator analysis revealed that HRV metric (p <0.001), position (p = 0.033), and biological sex (β = 0.45, 95% CI 0.30–0.61; p <0.001), but not portable device, modulated the degree of absolute error. Within metric, absolute error was significantly higher when expressed as standard deviation of all normal–normal (R–R) intervals (SDNN) (ES = 0.44) compared to any other metric, but was no longer significantly different after a sensitivity analysis removed outliers. Likewise, the error associated with the tilt/recovery position was significantly higher than any other position and remained significantly different without outliers in the model. Our results suggest that HRV measurements acquired using portable devices demonstrate a small amount of absolute error when compared to ECG. However, this small error is acceptable when considering the improved practicality and compliance of HRV measurements acquired through portable devices in the field setting. Practitioners and researchers should consider the cost–benefit along with the simplicity of the measurement when attempting to increase compliance in acquiring HRV measurements.

The Five Paradoxes of Meaningful Work: Introduction to the special Issue ‘Meaningful Work: Prospects for the 21st Century’

Abstract: In this introduction to the Journal of Management Studies Special Issue on Meaningful Work, we explain the imperative for a deeper understanding of meaningfulness within the context of the current socio-political environment, coupled with the growing use of organizational strategies aimed at ‘managing the soul’. Meaningful work remains a contested topic that has been the subject of attention in a wide range of disciplines. The focus of this Special Issue is the advancement of theory and evidence about the nature, causes, consequences and processes of meaningful work. We summarize the contributions of each of the seven articles that comprise the Special Issue and, in particular, note their methodological and theoretical plurality. In conclusion, we set forth a future research agenda based on five fundamental paradoxes of meaningful work.

Problematic Use of Mobile Phones in Australia…Is It Getting Worse?

Abstract: Rapid technological innovations over the past few years have led to dramatic changes in today's mobile phone technology. While such changes can improve the quality of life of its users, problematic mobile phone use can result in its users experiencing a range of negative outcomes such as anxiety or, in some cases, engagement in unsafe behaviors with serious health and safety implications such as mobile phone distracted driving. The aims of the present study are two-fold. First, this study investigated the current problem mobile phone use in Australia and its potential implications for road safety. Second, based on the changing nature and pervasiveness of mobile phones in Australian society, this study compared data from 2005 with data collected in 2018 to identify trends in problem mobile phone use in Australia. As predicted, the results demonstrated that problem mobile phone use in Australia increased from the first data collected in 2005. In addition, meaningful differences were found between gender and age groups in this study, with females and users in the 18–25 year-old age group showing higher mean Mobile Phone Problem Use Scale (MPPUS) scores. Additionally, problematic mobile phone use was linked with mobile phone use while driving. Specifically, participants who reported high levels of problem mobile phone use, also reported handheld and hands-free mobile phone use while driving.

Isometric training and long-term adaptations: Effects of muscle length, intensity, and intent: A systematic review.

Abstract: Isometric training is used in the rehabilitation and physical preparation of athletes, special populations, and the general public. However, little consensus exists regarding training guidelines for a variety of desired outcomes. Understanding the adaptive response to specific loading parameters would be of benefit to practitioners. The objective of this systematic review, therefore, was to detail the medium- to long-term adaptations of different types of isometric training on morphological, neurological, and performance variables. Exploration of the relevant subject matter was performed through MEDLINE, PubMed, SPORTDiscus, and CINAHL databases. English, full-text, peer-reviewed journal articles and unpublished doctoral dissertations investigating medium- to long-term (≥3 weeks) adaptations to isometric training in humans were identified. These studies were evaluated further for methodological quality. Twenty-six research outputs were reviewed. Isometric training at longer muscle lengths (0.86%-1.69%/week, ES = 0.03-0.09/week) produced greater muscular hypertrophy when compared to equal volumes of shorter muscle length training (0.08%-0.83%/week, ES = -0.003 to 0.07/week). Ballistic intent resulted in greater neuromuscular activation (1.04%-10.5%/week, ES = 0.02-0.31/week vs 1.64%-5.53%/week, ES = 0.03-0.20/week) and rapid force production (1.2%-13.4%/week, ES = 0.05-0.61/week vs 1.01%-8.13%/week, ES = 0.06-0.22/week). Substantial improvements in muscular hypertrophy and maximal force production were reported regardless of training intensity. High-intensity (≥70%) contractions are required for improving tendon structure and function. Additionally, long muscle length training results in greater transference to dynamic performance. Despite relatively few studies meeting the inclusion criteria, this review provides practitioners with insight into which isometric training variables (eg, joint angle, intensity, intent) to manipulate to achieve desired morphological and neuromuscular adaptations.

Markets changing, changing markets: Institutional work as market shaping:

Abstract: There is increasing interest in the marketing discipline to adopt an institutional perspective when examining markets. This requires seeing markets as complex systems that evolve through time, rath...

Reliability and validity of clinically accessible smartphone applications to measure joint range of motion: A systematic review

Abstract: Measuring joint range of motion is an important skill for many allied health professionals. While the Universal Goniometer is the most commonly utilised clinical tool for measuring joint range of motion, the evolution of smartphone technology and applications (apps) provides the clinician with more measurement options. However, the reliability and validity of these smartphones and apps is still somewhat uncertain. The aim of this study was to systematically review the literature regarding the intra- and inter-rater reliability and validity of smartphones and apps to measure joint range of motion. Eligible studies were published in English peer-reviewed journals with full text available, involving the assessment of reliability and/or validity of a non-videographic smartphone app to measure joint range of motion in participants >18 years old. An electronic search using PubMed, Medline via Ovid, EMBASE, CINAHL, and SPORTSDiscus was performed. The risk of bias was assessed using a standardised appraisal tool. Twenty-three of the eligible 25 studies exceeded the minimum 60% score to be classified as a low risk of bias, although 3 of the 13 criteria were not achieved in >50% of the studies. Most of the studies demonstrated adequate intra-rater or inter-rater reliability and/or validity for >50% of the range of motion tests across all joints assessed. However, this level of evidence appeared weaker for absolute (e.g. mean difference ± limit of agreement, minimal detectable change) than relative (e.g. intraclass correlation, correlation) measures; and for spinal rotation than spinal extension, flexion and lateral flexion. Our results provide clinicians with sufficient evidence to support the use of smartphones and apps in place of goniometers to measure joint motion. Future research should address some methodological limitations of the literature, especially including the inclusion of absolute and not just relative reliability and validity statistics.

Airborne microbial transport limitation to isolated Antarctic soil habitats

Abstract: Dispersal is a critical yet poorly understood factor underlying macroecological patterns in microbial communities1. Airborne microbial transport is assumed to occupy a central role in determining dispersal outcomes2,3, and extra-range dispersal has important implications for predicting ecosystem resilience and response to environmental change4. One of the most pertinent biomes in this regard is Antarctica, given its geographic isolation and vulnerability to climate change and human disturbance5. Here, we report microbial diversity in near-ground and high-altitude air above the largest ice-free Antarctic habitat, as well as that of underlying soil microbial communities. We found that persistent local airborne inputs were unable to fully explain Antarctic soil community assembly. Comparison with airborne microbial diversity from high-altitude and non-polar sources suggests that strong selection occurs during long-range atmospheric transport. The influence of selection during airborne transit and at sink locations varied between microbial phyla. Overall, the communities from this isolated Antarctic ecosystem displayed limited connectivity to the non-polar microbial pool, and alternative sources of recruitment are necessary to fully explain extant soil diversity. Our findings provide critical insights into the role of airborne transport limitation in determining microbial biogeographic patterns.

An Evolutionary Self-Cooperative Trust Scheme Against Routing Disruptions in MANETs

Abstract: How to achieve reliable routing has always been a major issue in the design of communication networks, among which mobile ad hoc networks (MANETs) possess the most adversarial networking environment due to the absence of fixed infrastructure, the nature of open transmission media and the dynamic network topology. These characteristics also make the design of routing protocols in MANETs become even more challenging. In this paper, we propose an evolutionary self-cooperative trust (ESCT) scheme that imitates human cognitive process and relies on trust-level information to prevent various routing disruption attacks. In this scheme, mobile nodes will exchange trust information and analyze received trust information based on their own cognitive judgment. Eventually, each node dynamically evolves its cognition to exclude malicious entities. The most attractive feature of ESCT is that they cannot compromise the system even if the internal attackers know how the security mechanism works. In this paper, we evaluate the performance of ESCT scheme under various routing disruption attack situations. Simulation results affirm that ESCT scheme promotes network scalability and ensures the routing effectiveness in the presence of routing disruption attackers in MANETs.

DevOps Capabilities, Practices, and Challenges: Insights from a Case Study

Abstract: DevOps is a set of principles and practices to improve collaboration between development and IT Operations. Against the backdrop of the growing adoption of DevOps in a variety of software development domains, this paper describes empirical research into factors influencing its implementation. It presents findings of an in-depth exploratory case study that explored DevOps implementation in a New Zealand product development organisation. The study involved interviewing six experienced software engineers who continuously monitored and reflected on the gradual implementation of DevOps principles and practices. For this case study the use of DevOps practices led to significant benefits, including increase in deployment frequency from about 30 releases a month to an average of 120 releases per month, as well as improved natural communication and collaboration between IT development and operations personnel. We found that the support of a number of technological enablers, such as implementing an automation pipeline and cross functional organisational structures, were critical to delivering the expected benefits of DevOps.

A fuzzy AHP-TOPSIS approach to supply partner selection in continuous aid humanitarian supply chains

Abstract: The selection of suitable supply partners is a strategic issue for managers working in humanitarian operations and has received little attention in the literature. In humanitarian operations, complexity characterizes the continuous-aid procurement operations, and the selection criteria can differ from those used in commercial supply chain settings. This paper advances knowledge by introducing a supply partner selection framework for continuous-aid procurement. A proposed multi-criteria decision-making model uses selection criteria attributes verified by the extant literature and by field experts. A fuzzy Analytic Hierarchy Process is then used to compute criterion weights, and a fuzzy Technique for Order Performance by Similarity to Ideal Solution is used to rank supply partner alternatives. Even with elevated levels of subjectivity, these techniques enable humanitarian operation stakeholders to select the best supply partner effectively. An actual case illustrates how the proposed framework efficiently identifies the most suitable continuous-aid supply partner for the prevailing situation.