Bharathiar University

About: Bharathiar University is a education organization based out in Coimbatore, Tamil Nadu, India. It is known for research contribution in the topics: Thin film & Adsorption. The organization has 5812 authors who have published 8628 publications receiving 143934 citations. The organization is also known as: BU.

Role of substitution at terminal nitrogen of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the coordination behavior and structure and biological properties of their palladium(II) complexes.

Abstract: A series of four new palladium(II) complexes of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones with triphenylphosphine as coligand have been synthesized and characterized by the aid of various spectral techniques. The single-crystal X-ray diffraction studies revealed that the unsubstituted thiosemicarbazone ligand acted as monobasic tridentate (ONS–) in the cationic [Pd(H-Qtsc-H)(PPh3)]Cl complex, whereas the monosubstituted thiosemicarbazone ligands acted as monobasic bidentate (NS–) in their respective complexes, [PdCl(H-Qtsc-R)(PPh3)] (R = Me (2), Et (3), Ph (4)). To ascertain the potentials of the above Pd(II) complexes toward biomolecular interactions, additional experiments involving interaction with calf thymus DNA and bovine serum albumin were carried out. Moreover, all the palladium(II) complexes have been screened for their radical scavenging activity toward DPPH, O2–, OH, and NO radicals. The efficiency of the complexes in arresting the growth of human cervical cancer cells (HeLa)...

Recent advances in radiotherapy and its associated side effects in cancer—a review

Abstract: Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades. Though RT is a momentous adjuvant non-invasive technique, it leaves behind some unsympathetic effects. Research is going on to surmount these pessimistic sides of RT. We made a mini review of recent articles from the period of 2000 to 2017 regarding radiotherapy and its side effects in various types of cancers. The literature review was done by searching in PUBMED, MEDLINE, and SCOPUS. Here, we spotlight the physiological and genetic risks associated with the cancer patients undergoing RT. We illustrated the course of RT in most prevalent cancers tailored with dosage distribution. Radiation-induced mutation in the patients undergoing RT has been shown with evidence. Further, the major drawbacks like the development of radiation resistance in cancerous cells and secondary malignancies have been discussed. The problems associated with radiation dosage in terms of infertility and rejuvenation of reproductive cells has also been discussed. Finally, we discussed the latest treatment stratagem of RT in cancer. Cancer treatment will not be accomplished devoid of radiotherapy. But we can brace RT using radiosensitizers and ayurvedic radioprotectors.

Electrochemical oxidation of paracetamol in water by graphite anode: Effect of pH, electrolyte concentration and current density

Abstract: Paracetamol is one of the micropollutant in water and most frequently used drugs as moderate pain reliever. These micropollutants are serious threat to human and environment. In the present investigation, we made attempt to degrade the electrochemical oxidation of paracetamol in water by graphite as anode. Electrooxidation behavior of paracetamol at graphite anode was tested by cyclic voltammetry technique performed in the potential range of -1.0 to +1.0 V versus Ag/AgCl. The optimized conditions were obtained by varying different factors, such as electrolyte concentration (0.02-0.1 M), current density (3.1–7.1 mA/cm2), initial pH (4–8) and paracetamol concentration (20 mg L−1). The results showed that the maximum removal of paracetamol concentration, chemical oxygen demand (COD) and total organic carbon (TOC) reached >90%, >82% and >65% after 240 min electrolysis at an initial pH 4, having paracetamol concentration of 20 mg L−1 at a constant current density of 5.1 mA/cm2 with 0.1 M Na2SO4 supporting electrolyte. Different SO42- concentrations in water promoted the electro generation of strong mediator oxidant species, such as OH, SO4 - and S2O82- increasing the removal efficiency of paracetamol. The degradation of paracetamol and its mineralization trend were monitored by UV–vis spectrophotometric method and total organic carbon (TOC) analyzer, respectively. FT-IR spectra confirmed that the functional group changes after electrolysis of paracetamol. HPLC studies revealed the byproduct (hydroquinone, benzoquinone and carboxylic acid) formation during the electrolysis process. On the other hand, researchers are actively involved in ozonation, photocatalysis, activated charcoal and biological treatments etc., to remove/degrade micropollutant, which are major drawbacks for the implications.