Congrès International d'Architecture Moderne

About: Congrès International d'Architecture Moderne is a based out in . It is known for research contribution in the topics: Boundary value problem & Jet (fluid). The organization has 393 authors who have published 403 publications receiving 4104 citations.

Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19.

Abstract: Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low immunogenicity and their ability to self-renew, to differentiate into different tissue-specific progenitors, to migrate into damaged sites, and to act through autocrine and paracrine pathways have been altogether testified as the main mechanisms whereby cell repair and regeneration occur. The absence of standardization protocols in cell management within laboratories or facilities added to the new technologies improved at patient's bedside and the discrepancies in cell outcomes and engraftment increase the limitations on their widespread use by balancing their real benefit versus the patient safety and security. Also, comparisons across pooled patients are particularly difficult in the fact that multiple medical devices are used and there is absence of harmonized assessment assays despite meeting regulations agencies and efficient GMP protocols. Moreover, the emergence of the COVID-19 breakdown added to the complexity of implementing standardization. Cell- and tissue-based therapies are completely dependent on the biological manifestations and parameters associated to and induced by this virus where the scope is still unknown. The initial flow chart identified for stem cell therapies should be reformulated and updated to overcome patient infection and avoid significant variability, thus enabling more patient safety and therapeutic efficiency. The aim of this work is to highlight the major guidelines and differences in ADSC processing meeting the current good manufacturing practices (cGMP) and the cellular therapy-related policies. Specific insights on standardization of ADSCs proceeding at different check points are also presented as a setup for the cord blood and bone marrow.

Environmental applications of solid-phase microextraction

Abstract: Solid-phase microextraction is a well-established green solvent free extraction technique with a large number of applications in different fields such as food, forensic, biomedical, and the environment. The present review comprehensively describes the most recent applications mostly reported from 2013 of SPME for the extraction of environmental pollutants including persistent organic pollutants (POPs), pesticides, and emerging pollutants such as pharmaceuticals and personal care products (PPCPs), in different environmental matrices. This review also covers the last technological developments including the use of novel extraction coatings (MOFs, CNTs, ILs), formats (e.g. TFSE), approaches (e.g. vacuum, cold fiber, and in-tube SPME), and on-site devices. The hyphenation of SPME with other techniques, especially mass spectrometry will be described, as well. The usefulness of SPME to follow (photo)degradation studies, both in target and non-target analysis, as well as to determine some of the physicochemical parameters governing the pollutant fate in the environment is also illustrated through different examples.