Congrès International d'Architecture Moderne

About: Congrès International d'Architecture Moderne is a based out in . It is known for research contribution in the topics: Boundary value problem & Jet (fluid). The organization has 393 authors who have published 403 publications receiving 4104 citations.

Impact of control interventions on COVID-19 population dynamics in Malaysia: a mathematical study

Abstract: Coronavirus disease 2019 (COVID-19) pandemic has posed a serious threat to both the human health and economy of the affected nations. Despite several control efforts invested in breaking the transmission chain of the disease, there is a rise in the number of reported infected and death cases around the world. Hence, there is the need for a mathematical model that can reliably describe the real nature of the transmission behaviour and control of the disease. This study presents an appropriately developed deterministic compartmental model to investigate the effect of different pharmaceutical (treatment therapies) and non-pharmaceutical (particularly, human personal protection and contact tracing and testing on the exposed individuals) control measures on COVID-19 population dynamics in Malaysia. The data from daily reported cases of COVID-19 between 3 March and 31 December 2020 are used to parameterize the model. The basic reproduction number of the model is estimated. Numerical simulations are carried out to demonstrate the effect of various control combination strategies involving the use of personal protection, contact tracing and testing, and treatment control measures on the disease spread. Numerical simulations reveal that the implementation of each strategy analysed can significantly reduce COVID-19 incidence and prevalence in the population. However, the results of effectiveness analysis suggest that a strategy that combines both the pharmaceutical and non-pharmaceutical control measures averts the highest number of infections in the population.

Antioxidant power, bacteriostatic activity, and characterization of white grape pomace extracts by HPLC–ESI–MS

Abstract: Polyphenolic fractions obtained from white grape pomace by aqueous extraction were analyzed to determine their antioxidant power (DPPH and TBARS methods), bacteriostatic activity, the effect of particle size on total extractable polyphenols (expressed as gallic acid equivalents (GAE)), and to characterize by HPLC–ESI–MS. The extraction of polyphenols from Albarino variety grape pomace was performed both on lab-scale and on pilot-plant scale using particles sizes of <1 mm, 3–5 mm and entire particle. Lab-scale assays showed that the lower the particle size the higher the raw extract (RE) percentage (%w/w), which values were 21.3 ± 0.37% (SD), 12.6 ± 0.38%, and 6.6 ± 0.44%, respectively. Several fractions were obtained from RE, either as result of applying liquid–liquid partition or gel permeation chromatography. The antiradical activities of the fractions were lower than that of gallic acid (17.8 ± 0.1 mg GAE/mol DPPH) but similar to that of catechin or procyanidin B2 (46.0 ± 2.3 mg GAE/mol DPPH and 52.3 ± 6.3 mg GAE/mol DPPH). Several fractions showed bacteriostatic activity both at 50 and at 100 mg/L. Total aerobic bacterial enumeration (TABE, log UFC/cm2) of treated samples revealed a significant lower TABE than that for control. HPLC–ESI–MS studies demonstrated that fractions V and VI included monomers, dimers, and trimers of procyanidins, few of them galloylated. Fraction VII contained several oligomers and galloylated procyanidins.

A multifractal approach to characterize cumulative rainfall and tillage effects on soil surface micro-topography and to predict depression storage

Abstract: . Most of the indices currently employed for assessing soil surface micro-topography, such as random roughness (RR), are merely descriptors of its vertical component. Recently, multifractal analysis provided a new insight for describing the spatial configuration of soil surface roughness. The main objective of this study was to test the ability of multifractal parameters to assess in field conditions the decay of initial surface roughness induced by natural rainfall under different soil tillage systems. In addition, we evaluated the potential of the joint use of multifractal indices plus RR to improve predictions of water storage in depressions of the soil surface (MDS). Field experiments were performed on an Oxisol at Campinas, Sao Paulo State (Brazil). Six tillage treatments, namely, disc harrow, disc plough, chisel plough, disc harrow + disc level, disc plough + disc level and chisel plough + disc level were tested. In each treatment soil surface micro-topography was measured four times, with increasing amounts of natural rainfall, using a pin meter. The sampling scheme was a square grid with 25 × 25 mm point spacing and the plot size was 1350 × 1350 mm (≈1.8 m2), so that each data set consisted of 3025 individual elevation points. Duplicated measurements were taken per treatment and date, yielding a total of 48 experimental data sets. MDS was estimated from grid elevation data with a depression-filling algorithm. Multifractal analysis was performed for experimental data sets as well as for oriented and random surface conditions obtained from the former by removing slope and slope plus tillage marks, respectively. All the investigated microplots exhibited multifractal behaviour, irrespective of surface condition, but the degree of multifractality showed wide differences between them. Multifractal parameters provided valuable information for characterizing the spatial features of soil micro-topography as they were able to discriminate data sets with similar values for the vertical component of roughness. Conversely, both, rough and smooth soil surfaces, with high and low roughness values, respectively, can display similar levels of spectral complexity. Although in most of the studied cases trend removal produces increasing homogeneity in the spatial configuration of height readings, spectral complexity of individual data sets may increase or decrease, when slope or slope plus tillage tool marks are filtered. Increased cumulative rainfall had significant effects on various parameters from the generalized dimension, Dq, and singularity spectrum, f(α). Overall, micro-topography decay by rainfall was reflected on a shift of the singularity spectra, f(α) from the left side (q>>0) to the right side (q >0) to the left side (q

Numerical experiment on conformal mapping of doubly connected regions onto a disk with a slit

Abstract: We present a method for computing the conformal mapping function of doubly connected regions bounded by two closed Jordan curves onto a disk with a concentric circular slit of radius . Our mapping procedure consists of two parts. First we solve a system of integral equations on the boundary of the region we wish to map. The system of integral equations is based on a boundary integral equation involving the Neumann kernel discovered by the authors satisfied by , , and , where is a fixed interior point with predetermined. The boundary values of are completely determined from the boundary values of through a boundary relationship. Discretization of the integral equation leads to a system of non-linear equations. Together with some normalizing conditions, a unique solution to the system is then computed by means of an optimization method called the Lavenberg-Marquadt algorithm. Once we have determined the boundary values of , we use the Cauchy integral formula to compute the interior of the regions. Typical examples for some doubly connected regions show that numerical results of high accuracy can be obtained for the conformal mapping problem when the boundaries are sufficiently smooth

Skin Immunomodulation during Regeneration: Emerging New Targets

Abstract: Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and thus skin function These useful features of ADSCs are involved in tissue repair, where the required cell proliferation, angiogenesis, and anti-inflammatory responses should occur rapidly in damaged sites Different pathways involved have been reported such as Growth Differentiation Factor-11 (GDF11), Tumor Growth Factor (TGF)-β, Metalloproteinase (MMP), microRNA, and inflammatory cytokines that might serve as specific biomarkers of their immunomodulating capacity In this review, we try to highlight ADSCs' network and explore the potential indicators of their immunomodulatory effect in skin regeneration and aging Assessment of these biomarkers might be useful and should be considered when designing new clinical therapies using ADSCs or their specific exosomes focusing on their immunomodulation activity