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Showing papers by "Manchester Metropolitan University published in 2016"


Journal ArticleDOI
TL;DR: The physiological rationale for physical activity, risks of adverse events, societal and psychological factors are discussed with a view to inform public health initiatives for the relatively healthy older person as well as those with physical frailty.
Abstract: Regular physical activity helps to improve physical and mental functions as well as reverse some effects of chronic disease to keep older people mobile and independent. Despite the highly publicised benefits of physical activity, the overwhelming majority of older people in the United Kingdom do not meet the minimum physical activity levels needed to maintain health. The sedentary lifestyles that predominate in older age results in premature onset of ill health, disease and frailty. Local authorities have a responsibility to promote physical activity amongst older people, but knowing how to stimulate regular activity at the population-level is challenging. The physiological rationale for physical activity, risks of adverse events, societal and psychological factors are discussed with a view to inform public health initiatives for the relatively healthy older person as well as those with physical frailty. The evidence shows that regular physical activity is safe for healthy and for frail older people and the risks of developing major cardiovascular and metabolic diseases, obesity, falls, cognitive impairments, osteoporosis and muscular weakness are decreased by regularly completing activities ranging from low intensity walking through to more vigorous sports and resistance exercises. Yet, participation in physical activities remains low amongst older adults, particularly those living in less affluent areas. Older people may be encouraged to increase their activities if influenced by clinicians, family or friends, keeping costs low and enjoyment high, facilitating group-based activities and raising self-efficacy for exercise.

716 citations


Journal ArticleDOI
TL;DR: This paper examined the social and legal conditions in which many transgender people (often called trans people) live, and the medical perspectives that frame the provision of health care for transgender people across much of the world.

623 citations


Journal ArticleDOI
TL;DR: Whereas the strictest regimes of PA management attempted to exclude anthropogenic influences to achieve biological conservation objectives, PAs that explicitly integrated local people as stakeholders tended to be more effective at achieving joint biological conservation and socioeconomic development outcomes.
Abstract: Protected areas (PAs) are a key strategy for protecting biological resources, but they vary considerably in their effectiveness and are frequently reported as having negative impacts on local people. This has contributed to a divisive and unresolved debate concerning the compatibility of environmental and socioeconomic development goals. Elucidating the relationship between positive and negative social impacts and conservation outcomes of PAs is key for the development of more effective and socially just conservation. We conducted a global meta-analysis on 165 PAs using data from 171 published studies. We assessed how PAs affect the well-being of local people, the factors associated with these impacts, and crucially the relationship between PAs' conservation and socioeconomic outcomes. Protected areas associated with positive socioeconomic outcomes were more likely to report positive conservation outcomes. Positive conservation and socioeconomic outcomes were more likely to occur when PAs adopted comanagement regimes, empowered local people, reduced economic inequalities, and maintained cultural and livelihood benefits. Whereas the strictest regimes of PA management attempted to exclude anthropogenic influences to achieve biological conservation objectives, PAs that explicitly integrated local people as stakeholders tended to be more effective at achieving joint biological conservation and socioeconomic development outcomes. Strict protection may be needed in some circumstances, yet our results demonstrate that conservation and development objectives can be synergistic and highlight management strategies that increase the probability of maximizing both conservation performance and development outcomes of PAs.

479 citations


Journal ArticleDOI
TL;DR: In this article, a model theorizing social media as a space for learning with varying attributes of formality and informality is proposed, together with social constructivism and connectivism as theoretical lenses through which to tease out the complexities of learning in various settings.
Abstract: It is argued that social media has the potential to bridge formal and informal learning through participatory digital cultures. Exemplars of sophisticated use by young people support this claim, although the majority of young people adopt the role of consumers rather than full participants. Scholars have suggested the potential of social media for integrating formal and informal learning, yet this work is commonly under-theorized. We propose a model theorizing social media as a space for learning with varying attributes of formality and informality. Through two contrasting case studies, we apply our model together with social constructivism and connectivism as theoretical lenses through which to tease out the complexities of learning in various settings. We conclude that our model could reveal new understandings of social media in education, and outline future research directions.

455 citations


Journal ArticleDOI
TL;DR: The 4th International Patellofemoral Research Retreat was held in Manchester, UK, over 3 days (September 2–4th, 2015) and developed a consensus statement addressing different presentation categories, including PFP and factors that influence PFP.
Abstract: Patellofemoral pain (PFP) typically presents as diffuse anterior knee pain, usually with activities such as squatting, running, stair ascent and descent. It is common in active individuals across the lifespan,1–4 and is a frequent cause for presentation at physiotherapy, general practice, orthopaedic and sports medicine clinics in particular.5 ,6 Its impact is profound, often reducing the ability of those with PFP to perform sporting, physical activity and work-related activities pain-free. Increasing evidence suggests that it is a recalcitrant condition, persisting for many years.7–9 In an attempt to share recent innovations, build on the first three successful biennial retreats and define the ‘state of the art’ for this common, impactful condition; the 4th International Patellofemoral Pain Research Retreat was convened. The 4th International Patellofemoral Research Retreat was held in Manchester, UK, over 3 days (September 2–4th, 2015). After undergoing peer-review for scientific merit and relevance to the retreat, 67 abstracts were accepted for the retreat (50 podium presentations, and 17 short presentations). The podium and short presentations were grouped into five categories; (1) PFP, (2) factors that influence PFP (3) the trunk and lower extremity (4) interventions and (5) systematic analyses. Three keynote speakers were chosen for their scientific contribution in the area of PFP. Professor Andrew Amis spoke on the biomechanics of the patellofemoral joint. Professor David Felson spoke on patellofemoral arthritis,10 and Dr Michael Ratleff's keynote theme was PFP in the adolescent patient.11 As part of the retreat, we held structured, whole-group discussions in order to develop consensus relating to the work presented at the meeting as well as evidence gathered from the literature. ### Consensus development process In our past three International Patellofemoral Research Retreats, we developed a consensus statement addressing different presentation categories.12–14 In Manchester in 2015, we revised the format. For the exercise and …

312 citations


Book ChapterDOI
01 Jan 2016
TL;DR: The results of this study revealed that social presence in mixed (VR & AR) environments is a strong predictor of four realms of experience economy, which consequently induce the tourists’ intention to revisit Geevor museum.
Abstract: This study aims to investigate the impact of Virtual Reality (VR) and Augmented Reality (AR) on the overall visitor experience in the context of museum. In tourism research, few attempts have been made to examine factors which enhance visitor experience using new and emerging technologies such as VR & AR respectively, however research on visitor experience in the mixed environment by combining both VR & AR is scarce. In particular, this study examined the impact of social presence on visitor experience in the mixed (VR & AR) environment by applying social presence theory and experience economy theory. Questionnaires administered to 163 museum visitors revealed that social presence in mixed (VR & AR) environments is a strong predictor of four realms of experience economy. Furthermore, all aspects of experience economy, except for esthetic experience, have a significant influence on visitor experience, which consequently induce the tourists’ intention to revisit Geevor museum. The results of this study provide theoretical and managerial implications for adoption of VR & AR technologies in museum.

279 citations


Journal ArticleDOI
TL;DR: Carbon dots inducing petal-like rutile TiO2 wrapped by ultrathin graphene-rich layers are proposed to fabricate superior anodes for sodium-ion batteries, featuring high-rate capabilities and long-term cyclelife, benefiting from promoted electron transport and a shortened Na+ diffusion length.
Abstract: Carbon dots inducing petal-like rutile TiO2 wrapped by ultrathin graphene-rich layers are proposed to fabricate superior anodes for sodium-ion batteries, featuring high-rate capabilities and long-term cyclelife, benefiting from promoted electron transport and a shortened Na+ diffusion length. High capacities of 144.4 mA h g-1 (at 837.5 mA g-1 ) after 1100 cycles and 74.6 mA h g-1 (at 3350 mA g-1 ) after 4000 cycles are delivered outstandingly.

250 citations


Journal ArticleDOI
TL;DR: The true effect of obesity upon skeletal muscle size, structure and function, including any interactions with ageing effects, remains to be elucidated.
Abstract: Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compared to non-obese persons, suggesting that increased adiposity acts as a chronic overload stimulus on the antigravity muscles (e.g., quadriceps and calf), thus increasing muscle size and strength. However, when maximum muscular strength is normalised to body mass, obese individuals appear weaker. This relative weakness may be caused by reduced mobility, neural adaptations and changes in muscle morphology. Discrepancies in the literature remain for maximal strength normalised to muscle mass (muscle quality) and can potentially be explained through accounting for the measurement protocol contributing to muscle strength capacity that need to be explored in more depth such as antagonist muscle co-activation, muscle architecture, a criterion valid measurement of muscle size and an accurate measurement of physical activity levels. Current evidence demonstrating the effect of obesity on muscle quality is limited. These factors not being recorded in some of the existing literature suggest a potential underestimation of muscle force either in terms of absolute force production or relative to muscle mass; thus the true effect of obesity upon skeletal muscle size, structure and function, including any interactions with ageing effects, remains to be elucidated.

246 citations


Journal ArticleDOI
TL;DR: A consensus meeting to update the current evidence base and produce consensus-based recommendations regarding treatment for patellofemoral pain was held in Manchester 2015, where many of the world leading researchers were in attendance and contributed to the consensus meeting.
Abstract: Patellofemoral pain affects physically active and sedentary individuals, accounting for 11–17% of knee pain presentations to general practice1 ,2 and 25–40% of all knee problems seen in a sports injury clinic.3 ,4 Patellofemoral pain is characterised by anterior knee pain associated with activities such as squatting, rising from sitting and stair ambulation. While traditionally viewed as self-limiting, increasing research data suggest that patellofemoral pain is often recalcitrant and can persist for many years,5–8 and may cause a decline in sports participation.8 ,9 Despite its high prevalence among active individuals9–12 and frequent presentations for treatment, there are few published guidelines to help clinicians choose the appropriate evidence-based treatment for patellofemoral pain. The most recent and relevant paper from Barton and colleagues13 combined systematic review findings with qualitative interviews from expert clinicians to provide a clinically relevant synthesis, covering the literature up to September 2013. At the International Patellofemoral Pain Research Retreat in Manchester 2015, we held a consensus meeting to update the current evidence base and produce consensus-based recommendations regarding treatment for patellofemoral pain. All retreat registrants were active researchers in patellofemoral pain and presented their research findings. Many of the world leading researchers (eg, 8 out of the top 10 researchers with the highest number of publications, when the term ‘patellofemoral pain’ was searched in Scopus, February 2016) were in attendance and contributed to the consensus meeting. The consensus meeting during the retreat resulted in recommendations, based on evidence published between January 2010 and June 2015. These recommendations should be combined with information gathered from individual patients, regarding their preferences, experiences, presentation and values, along with the values, expertise and skills of individual practitioners to create a patient-centred treatment approach. ### Literature review CJB searched EMBASE, MEDLINE, CINAHL and Current Contents for systematic reviews …

196 citations


Journal ArticleDOI
TL;DR: Qualitative results indicated that connection to nature was significantly related to lower levels of overall, state cognitive and trait cognitive anxiety and opportunities that enhance experiences of being connected to nature may reduce unhelpful anxiety.
Abstract: This study investigated the relationship between anxiety and feelings of being connected to nature. Two standardised self-report scales, the Nature Relatedness Scale and the State Trait Inventory for Cognitive and Somatic Anxiety, were used in tandem with a qualitative question. Quantitative results indicated that connection to nature was significantly related to lower levels of overall, state cognitive and trait cognitive anxiety. Qualitative results revealed seven themes: relaxation, time out, enjoyment, connection, expanse, sensory engagement and a healthy perspective. Taken together, these results suggest that opportunities that enhance experiences of being connected to nature may reduce unhelpful anxiety.

189 citations


Journal ArticleDOI
TL;DR: This article first reviews the available neurophysiological and behavioral evidence for the effects of combined action observation and motor imagery (AO+MI) on motor processes, and advocates a more integrated approach to AO+ MI techniques than has previously been adopted by movement scientists and practitioners alike.
Abstract: Motor imagery (MI) and action observation (AO) have traditionally been viewed as two separate techniques, which can both be used alongside physical practice to enhance motor learning and rehabilitation. Their independent use has been shown to be effective, and there is clear evidence that the two processes can elicit similar activity in the motor system. Building on these well-established findings, research has now turned to investigate the effects of their combined use. In this article, we first review the available neurophysiological and behavioral evidence for the effects of combined action observation and motor imagery (‘AO+MI’) on motor processes. We next describe a conceptual framework for their combined use, and then discuss several areas for future research into AO+MI processes. In this review, we advocate a more integrated approach to AO+MI techniques than has previously been adopted by movement scientists and practitioners alike. We hope this early review of an emergent body of research, along with a related set of research questions, can inspire new work in this area. We are optimistic that future research will further confirm if, how, and when this combined approach to AO+MI can be more effective in motor learning and rehabilitation settings, relative to the more traditional application of AO or MI independently.

Journal ArticleDOI
TL;DR: Examination of the evidence revealed that some people with intellectual disability are having positive experiences using social media in terms of friendships, development of social identity and self-esteem, and enjoyment, but barriers that stop people with Intellectual disability from successfully accessing social media were identified as being safeguarding concerns, difficulties caused by literacy and communication skills, cyber-language, cyber
Abstract: Background In this paper we present a systematic review of the evidence on the use of social media by people with intellectual disability.Method Ten primary studies published in the English language between January 2000 and June 2014 were identified from electronic database searches (CINAHL, PsychInfo, PubMed, Web of Knowledge, and Scopus), correspondence with experts, and citation tracking.Results Nine themes were identified through thematic analysis of the texts: “safety and safeguarding,” “social identity,” “level of usage,” “support,” “relationships,” “happiness and enjoyment,” “communication and literacy skills,” “cyber-language and cyber-etiquette,” and “accessibility/design”.Conclusion Examination of these themes revealed that some people with intellectual disability are having positive experiences using social media in terms of friendships, development of social identity and self-esteem, and enjoyment. However, barriers that stop people with intellectual disability from successfully access...

Journal ArticleDOI
TL;DR: In this article, the implications of sustainable development trends and future directions universities might take under a potential second decade (2015-2024) are analyzed, based upon a combination of various futures studies methods.

Journal ArticleDOI
TL;DR: Different attachment and connectedness relationships, although related, predict adolescent mental health outcomes in distinct ways, whereas improving peer attachment and school connectedness could be important for the display of prosocial behaviour.
Abstract: Background Adolescent attachment relationships with parents and peers and the sense of connectedness with the schools attended have been established as salient predictors of psychological well-being. Few studies, however, have assessed the relative importance of each attachment or connectedness relationship and how they interrelate to influence mental health outcomes. Method A total of 203 adolescents (11–16 years) completed self-report measures of parental and peer attachment (Inventory of Parental & Peer Attachment – Revised; Gullone & Robinson, 2005); school connectedness (Psychological Sense of School Membership; Goodenow, 1993); conduct problems, emotional symptoms and prosocial behaviour (Strengths and Difficulties Questionnaire; Goodman, 1997). Results Multiple regression analyses demonstrated that more insecure parental attachment (although not peer attachment or school connectedness) predicted conduct problems and emotional difficulties. Peer attachment and school connectedness were significant predictors of prosocial behaviour, whereas parental attachment was not. A mediational analysis revealed that peer attachment and school connectedness both mediate the relationship between parental attachment and prosocial behaviour. No significant moderation effects of either peer attachment or school connectedness on the relationship between parental attachment and mental health outcomes were found. Conclusions Different attachment and connectedness relationships, although related, predict adolescent mental health outcomes in distinct ways. Improving parental attachment may have particular salience in reducing negative behaviours such as conduct problems and emotional difficulties, whereas improving peer attachment and school connectedness could be important for the display of prosocial behaviour.

Journal ArticleDOI
TL;DR: 2D-hBN is found to be an effective electrocatalyst in the simultaneous detection of DA and UA at both pH 5.0 and 7.4, and the underlying mechanisms of the aforementioned examples are explored and infer that electrode surface interactions and roughness factors are critical considerations.
Abstract: Crystalline 2D hexagonal boron nitride (2D-hBN) nanosheets are explored as a potential electrocatalyst toward the electroanalytical sensing of dopamine (DA). The 2D-hBN nanosheets are electrically wired via a drop-casting modification process onto a range of commercially available carbon supporting electrodes, including glassy carbon (GC), boron-doped diamond (BDD), and screen-printed graphitic electrodes (SPEs). 2D-hBN has not previously been explored toward the electrochemical detection/electrochemical sensing of DA. We critically evaluate the potential electrocatalytic performance of 2D-hBN modified electrodes, the effect of supporting carbon electrode platforms, and the effect of “mass coverage” (which is commonly neglected in the 2D material literature) toward the detection of DA. The response of 2D-hBN modified electrodes is found to be largely dependent upon the interaction between 2D-hBN and the underlying supporting electrode material. For example, in the case of SPEs, modification with 2D-hBN (3...

Journal ArticleDOI
TL;DR: In this article, the authors develop an understanding of the human driven by a commitment to the politics of disability, especially those of people with intellectual disabilities, and sketch out four dis/human considerations: dis/autonomy, voice and evacuating the human individual, dis/independence, assemblage and collective humanness; dis/ability politics, self-advocacy and repositioning the human; and dis/family: desiring the normal, embracing the non-normative.
Abstract: In this paper, we seek to develop an understanding of the human driven by a commitment to the politics of disability, especially those of people with intellectual disabilities. Our position as family members and allies to people associated with this phenomenon of intellectual disability influences our philosophical conceptions and political responses. This has led us recently to develop a theory of dis/human studies which, we contend, simultaneously acknowledges the possibilities offered by disability to trouble, reshape and re-fashion the human (crip ambitions) while at the same time asserting disabled people's humanity (normative desires). We sketch out four dis/human considerations: (1) dis/autonomy, voice and evacuating the human individual; (2) dis/independence, assemblage and collective humanness; (3) dis/ability politics, self-advocacy and repositioning the human; and (4) dis/family: desiring the normal, embracing the non-normative. We argue that this feeds into the wider project of dis/ability studies, and we conclude that we desire a time when we view life through the prism of the dishuman (note, without the slash).

Journal ArticleDOI
TL;DR: This article explored previously theorised reasons for the failure of school-based, universal social and emotional learning (SEL) programs and expanded upon the extant prior meta-analytic literature.
Abstract: This study expands upon the extant prior meta-analytic literature by exploring previously theorised reasons for the failure of school-based, universal social and emotional learning (SEL) programmes...

Journal ArticleDOI
TL;DR: High performance liquid chromatography technique has been utilized to independently validate the electrochemical lactate biosensor for the determination of lactate in a commercial embryonic cell culture medium providing excellent agreement between the two analytical protocols.

Journal ArticleDOI
TL;DR: A lentiviral reporter system is developed to assay longitudinal changes in cell signaling and transcription factor activity in living cells throughout iPSC reprogramming of human dermal fibroblasts and shows that an early burst in oxidative phosphorylation and elevated reactive oxygen species generation mediates increased NRF2 activity, which initiates the HIFα-mediated glycolytic shift and may modulate glucose redistribution to the pentose phosphate pathway.

Journal ArticleDOI
TL;DR: The findings suggest that local extinctions caused by the loss and degradation of tropical forest are non-random with respect to functional traits, thus disrupting the network of trophic interactions regulating seed dispersal by forest birds and herbivory by insects, with important implications for the structure and resilience of human-modified tropical forests.
Abstract: Vertebrates perform key roles in ecosystem processes via trophic interactions with plants and insects, but the response of these interactions to environmental change is difficult to quantify in complex systems, such as tropical forests. Here, we use the functional trait structure of Amazonian forest bird assemblages to explore the impacts of land-cover change on two ecosystem processes: seed dispersal and insect predation. We show that trait structure in assemblages of frugivorous and insectivorous birds remained stable after primary forests were subjected to logging and fire events, but that further intensification of human land use substantially reduced the functional diversity and dispersion of traits, and resulted in communities that occupied a different region of trait space. These effects were only partially reversed in regenerating secondary forests. Our findings suggest that local extinctions caused by the loss and degradation of tropical forest are non-random with respect to functional traits, thus disrupting the network of trophic interactions regulating seed dispersal by forest birds and herbivory by insects, with important implications for the structure and resilience of human-modified tropical forests. Furthermore, our results illustrate how quantitative functional traits for specific guilds can provide a range of metrics for estimating the contribution of biodiversity to ecosystem processes, and the response of such processes to land-cover change.

Journal ArticleDOI
TL;DR: The present paper provides a first foundation for the implementation of wearable smart glasses AR applications in the museum and art gallery context and reveals that wearable AR is in its infancy and that technical and design issues have to be overcome for a full adoption.
Abstract: Purpose Recent advancements in wearable computing offer opportunities for art galleries to provide a unique experience. However, to ensure successful implementation of this new technology in the visitor industry, it is essential to understand user requirements from a visitor’s point of view. Therefore, the aim of this paper is to investigate visitors’ requirements for the development of a wearable smart glasses augmented reality (AR) application in the museum and art gallery context. Design/methodology/approach Interviews with 28 art gallery visitors were conducted and an affinity diagram technique was used to analyze the interviews. Findings The findings reveal that wearable AR is in its infancy and that technical and design issues have to be overcome for a full adoption. It reveals that content requirement, functional requirement, comfort, experience and resistance are important when developing and implementing the wearable AR application in the museum and art gallery contexts. Originality/value Mapping user requirements in the wearable smart glasses AR context using an affinity diagram is a new approach and therefore contributes to the creation of knowledge in the tourism domain. Practically, the area of wearable technologies and AR within the tourism and visitor industry context is still relatively unexplored, and the present paper provides a first foundation for the implementation of wearable smart glasses AR applications in the museum and art gallery context.

Journal ArticleDOI
TL;DR: In this paper, a low Si/Al ratio zeolite Y was used as a catalyst for liquid-phase esterification of oleic acid (a simulated free fatty acid) for biodiesel production.

Journal ArticleDOI
TL;DR: In this paper, the anterior thigh muscles are particularly susceptible to muscle loss and weakness during ageing, but it remains unclear how this is associated with changes to neuromuscular structure and function in terms of motor unit (MU) number, size and MU potential (MUP) stability.
Abstract: INTRODUCTION: The anterior thigh muscles are particularly susceptible to muscle loss and weakness during ageing, but it remains unclear how this is associated with changes to neuromuscular structure and function in terms of motor unit (MU) number, size and MU potential (MUP) stability. METHODS: Intramuscular and surface electromyographic (EMG) signals were recorded from the vastus lateralis (VL) during voluntary contractions held at 25% maximal knee extensor strength in 22 young (25.3 ± 4.8yrs) and 20 physically active older men (71.4 ± 6.2yrs). MUP size, firing rates, phases, turns and near fibre (NF) jiggle were determined and motor unit number estimates (MUNEs) were made by comparing average surface MUP with maximal electrically-evoked compound muscle action potentials. Quadriceps cross-sectional area was measured by magnetic resonance imaging. RESULTS: 379 individual MUs were sampled in young and 346 in older men. Compared with young, the older MUs had 8% lower firing rates and larger MUP size (∼+25%) as well as increased complexity evidenced as, phases (+13%), turns (+20%) and NF jiggle (+11%) (all P < 0.0005). The MUNE values (derived from the area of muscle in range of the surface-electrode) in older subjects were around 70% of the young (P < 0.05). Taking into consideration the 30% smaller cross-sectional area of the VL, the total number of MUs in the older muscles was between 50-60% lower than in the young (P < 0.0005). CONCLUSION: A large portion of the VL MU pool is lost in older men and those recruited during moderate intensity contractions were enlarged and less stable. These MU changes were evident before clinically relevant changes to muscle function were apparent; nevertheless, the changes in MU number and size are likely to be a prelude to future movement problems. This article is protected by copyright. All rights reserved.

Journal ArticleDOI
TL;DR: In this paper, the authors define the role of project-oriented learning, also designated as Project Based Learning, as a tool to support integrative approaches to sustainability in a higher education context.

Journal ArticleDOI
TL;DR: Loss of motor neurons and remodelling of surviving motor units constitutes the major change in ageing muscles and probably contributes to muscle loss and functional impairments.
Abstract: Voluntary control of skeletal muscle enables humans to interact with and manipulate the environment. Lower muscle mass, weakness and poor coordination are common complaints in older age and reduce physical capabilities. Attention has focused on ways of maintaining muscle size and strength by exercise, diet or hormone replacement. Without appropriate neural innervation, however, muscle cannot function. Emerging evidence points to a neural basis of muscle loss. Motor unit number estimates indicate that by age around 71 years, healthy older people have around 40 % fewer motor units. The surviving low- and moderate-threshold motor units recruited for moderate intensity contractions are enlarged by around 50 % and show increased fibre density, presumably due to collateral reinnervation of denervated fibres. Motor unit potentials show increased complexity and the stability of neuromuscular junction transmissions is decreased. The available evidence is limited by a lack of longitudinal studies, relatively small sample sizes, a tendency to examine the small peripheral muscles and relatively few investigations into the consequences of motor unit remodelling for muscle size and control of movements in older age. Loss of motor neurons and remodelling of surviving motor units constitutes the major change in ageing muscles and probably contributes to muscle loss and functional impairments. The deterioration and remodelling of motor units likely imposes constraints on the way in which the central nervous system controls movements.

Journal ArticleDOI
06 Jan 2016-PLOS ONE
TL;DR: It is argued that fragmentation of the existing Pygmy populations, alongside pressure from extractive industries and sometimes conflict with conservation areas, endanger their future and there is an urgent need to inform policies that can mitigate against future external threats to these indigenous peoples’ culture and lifestyles.
Abstract: Pygmy populations occupy a vast territory extending west-to-east along the central African belt from the Congo Basin to Lake Victoria. However, their numbers and actual distribution is not known precisely. Here, we undertake this task by using locational data and population sizes for an unprecedented number of known Pygmy camps and settlements (n = 654) in five of the nine countries where currently distributed. With these data we develop spatial distribution models based on the favourability function, which distinguish areas with favourable environmental conditions from those less suitable for Pygmy presence. Highly favourable areas were significantly explained by presence of tropical forests, and by lower human pressure variables. For documented Pygmy settlements, we use the relationship between observed population sizes and predicted favourability values to estimate the total Pygmy population throughout Central Africa. We estimate that around 920,000 Pygmies (over 60% in DRC) is possible within favourable forest areas in Central Africa. We argue that fragmentation of the existing Pygmy populations, alongside pressure from extractive industries and sometimes conflict with conservation areas, endanger their future. There is an urgent need to inform policies that can mitigate against future external threats to these indigenous peoples’ culture and lifestyles.

Journal ArticleDOI
TL;DR: The simulation results demonstrate that the proposed Next Road Rerouting (NRR) can achieve a lower average travel time while guaranteeing a higher travel time reliability in the face of unexpected congestion.
Abstract: During peak hours in urban areas, unpredictable traffic congestion caused by en route events (e.g., vehicle crashes) increases drivers' travel time and, more seriously, decreases their travel time reliability. In this paper, an original and highly practical vehicle rerouting system, which is called Next Road Rerouting (NRR), is proposed to aid drivers in making the most appropriate next road choice to avoid unexpected congestions. In particular, this heuristic rerouting decision is made upon a cost function that takes into account the driver's destination and local traffic conditions. In addition, the newly designed multiagent system architecture of NRR allows the positive rerouting impacts on local traffic to be disseminated to a larger area through the natural traffic flow propagation within connected local areas. The simulation results based on both synthetic and realistic urban scenarios demonstrate that, compared with the existing solutions, NRR can achieve a lower average travel time while guaranteeing a higher travel time reliability in the face of unexpected congestion. The impacts of NRR on the travel time of both rerouted and nonrerouted vehicles are also assessed, and the corresponding results reveal its higher practicability.

Journal ArticleDOI
TL;DR: In this paper, the authors focused on the island of Lesvos (Greece) and maps the environmental sensitivity of the island to land degradation and desertification between the years 1990 and 2000.
Abstract: In Europe, the most susceptible areas to land degradation and desertification (LDD) are found in the Mediterranean region. The present study focuses on the island of Lesvos (Greece) and maps the environmental sensitivity of the island to LDD between the years 1990 and 2000. Sensitivity is estimated with a modification of the MEDALUS Environmentally Sensitive Area Index (ESAI) approach, employing 21 quantitative parameters divided in five main quality indices: climate, vegetation, soils, groundwater and socio-economic quality. Parameterisation of these indices is achieved via remote sensing and ancillary data in a Geographical Information System (GIS). Results show that ~85% of the island is fragile or critically sensitive in both epochs. Fragile areas are on the increase, covering an estimated 72% of the island in 1990 and 77% in 2000, whereas critically sensitive areas decrease from 214 to 113 km2. By modifying the ESAI to include 10 additional parameters related to soil erosion, groundwater quality, demographic and grazing pressure, and by applying the modified ESAI in two—rather than one—periods, this study was able to identify that, contrary to previous belief, critically sensitive areas are also found in the eastern side of the island mainly due to human-related factors. It is concluded that the proposed methodology is a useful tool for regional scale trend analyses of environmental sensitivity and the identification of LDD hot spots in Mediterranean environments. Copyright © 2014 John Wiley & Sons, Ltd.

Journal ArticleDOI
TL;DR: Solutions include adoption of the term “intensity” in descriptions and categorizations of challenge imposed on an individual as they perform exercise, followed by correct use of SI terms and units appropriate to the specific kind of exercise performed.
Abstract: Despite the Systeme International d'Unites (SI) that was published in 1960, there continues to be widespread misuse of the terms and nomenclature of mechanics in descriptions of exercise performance. Misuse applies principally to failure to distinguish between mass and weight, velocity and speed, and especially the terms "work" and "power." These terms are incorrectly applied across the spectrum from high-intensity short-duration to long-duration endurance exercise. This review identifies these misapplications and proposes solutions. Solutions include adoption of the term "intensity" in descriptions and categorizations of challenge imposed on an individual as they perform exercise, followed by correct use of SI terms and units appropriate to the specific kind of exercise performed. Such adoption must occur by authors and reviewers of sport and exercise research reports to satisfy the principles and practices of science and for the field to advance.

Journal ArticleDOI
TL;DR: Overall, further research in elderly is required to increase the evidence and to either support or refute the current findings on sedentary behaviour in elderly, and to develop informed SB guidelines for an optimal strategy to counteract SB and its health effects in older adults.
Abstract: This literature review focuses on aspects of sedentary behaviour (SB) in elderly. Since it has been identified as a distinct health risk, independent of physical activity, SB is a significant issue. This is particularly true for an ageing population as evidence shows that older adults (aged ≥65 years) are the most sedentary age group (on average 8.5–9.6 h daily sitting time). Accurate SB assessment is important for understanding this habitual behaviour and its impact. However, SB measurement is challenging, regardless of the method used. Although negative associations of SB in elderly have been reported for several health outcomes, evidence is inconclusive, apart from the evidence on the adverse SB effect on the all-cause mortality rate. Generally, strategies have been proposed to counteract SB, of which breaking prolonged sedentary bouts with at least light-intensity physical activity seems to be the most promising. Overall, further research in elderly is required to increase the evidence and to either support or refute the current findings. Moreover, further research will help to develop informed SB guidelines for an optimal strategy to counteract SB and its health effects in older adults.