Institution
Polytechnic University of Milan
Education•Milan, Italy•
About: Polytechnic University of Milan is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Computer science & Finite element method. The organization has 18231 authors who have published 58416 publications receiving 1229711 citations. The organization is also known as: PoliMi & L-NESS.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The crystal structures presented here prove how halogen bonds can occur in biological systems and provide a class of highly directional stabilizing contacts that can be exploited in the process of rational drug design.
Abstract: Halogen bonding has been extensively described in the context of a variety of self-assembled supramolecular systems and efficiently utilized in the rational design of materials with specific structural properties. However, it has so far received only little recognition for its possible role in the stabilization of small molecule–protein complexes. In this tutorial review, we provide a few examples of halogen bonds occurring between small halogen-substituted ligands and their biological substrates. Examples were drawn from a diverse set of compounds, ranging from chemical additives and possible environmental agents such as triclosan to pharmacologically active principles such as the volatile anesthetic halothane or HIV-1 reverse transcriptase inhibitors or a subset of non-steroidal anti-inflammatory drugs (NSAIDs) that are halogen-substituted. The crystal structures presented here, where iodine, bromine, or chlorine atoms function as halogen bonding donors and a variety of electron rich sites, such as oxygen, nitrogen and sulfur atoms, as well as aromatic π-electron systems, function as halogen bonding acceptors, prove how halogen bonds can occur in biological systems and provide a class of highly directional stabilizing contacts that can be exploited in the process of rational drug design.
373 citations
••
TL;DR: In this article, the optimal and robust design of a four-section countercurrent adsorption separation unit is investigated in the frame of equilibrium theory, using a model where the ad-ption equilibria are described through the constant selectivity stoichiometric model, while mass transfer resistances and axial mixing are neglected.
Abstract: The separation of a binary mixture, using a third component having intermediate adsorptivity as desorbent, in a four section countercurrent adsorption separation unit is considered. A procedure for the optimal and robust design of the unit is developed in the frame of Equilibrium Theory, using a model where the adsorption equilibria are described through the constant selectivity stoichiometric model, while mass-transfer resistances and axial mixing are neglected. By requiring that the unit achieves complete separation, it is possible to identify a set of implicity constraints on the operating parameters, that is, the flow rate ratios in the four sections of the unit. From these constraints explicit bounds on the operating parameters are obtained, thus yielding a region in the operating parameters space, which can be drawn a priori in terms of the adsorption equilibrium constants and the feed composition. This result provides a very convenient tool to determine both optimal and robust operating conditions. The latter issue is addressed by first analyzing the various possible sources of disturbances, as well as their effect on the separation performance. Next, the criteria for the robust design of the unit are discussed. Finally, these theoretical findings are compared with a set of experimentalmore » results obtained in a six port simulated moving bed adsorption separation unit operated in the vapor phase.« less
370 citations
••
TL;DR: In this paper, a detailed investigation of the time evolution for the low-field resistance R/sub off/ and the threshold voltage V/sub th/ in chalcogenide-based phase-change memory devices is presented.
Abstract: A detailed investigation of the time evolution for the low-field resistance R/sub off/ and the threshold voltage V/sub th/ in chalcogenide-based phase-change memory devices is presented. It is observed that both R/sub off/ and V/sub th/ increase and become stable with time and temperature, thus improving the cell readout window. Relying on a microscopic model, the drift of R/sub off/ and V/sub th/ is linked to the dynamic of the intrinsic traps typical of amorphous chalcogenides, thus providing for the first time a unified framework for the comprehension of chalcogenide materials transient behavior.
370 citations
••
TL;DR: This review aims to be a critical re-examination of the experimental and theoretical tools used to investigate thermophoresis, and of some recent relevant results that may unravel novel aspects of colloid solvation forces.
Abstract: Thermophoresis is particle motion induced by thermal gradients Akin to other driven transport processes, such as the Soret effect in simple fluid mixtures, or electrophoresis and diffusiophoresis in colloidal suspensions, it is, both experimentally and theoretically, a challenging subject Rather than being a comprehensive recollection, this review aims to be a critical re-examination of the experimental and theoretical tools used to investigate thermophoresis, and of some recent relevant results that may unravel novel aspects of colloid solvation forces The perspectives of thermophoresis as a tool for particle manipulation in microfluidics are also emphasized
370 citations
••
TL;DR: In this paper, the authors derive an empirical model that aims at highlighting the inducements and obstacles that new technology-based firms face in alliance formation according to firm-specific characteristics and the nature of the alliance.
370 citations
Authors
Showing all 18743 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alex J. Barker | 132 | 1273 | 84746 |
Pierluigi Zotto | 128 | 1197 | 78259 |
Andrea C. Ferrari | 126 | 636 | 124533 |
Marco Dorigo | 105 | 657 | 91418 |
Marcello Giroletti | 103 | 558 | 41565 |
Luciano Gattinoni | 103 | 610 | 48055 |
Luca Benini | 101 | 1453 | 47862 |
Alberto Sangiovanni-Vincentelli | 99 | 934 | 45201 |
Surendra P. Shah | 99 | 710 | 32832 |
X. Sunney Xie | 98 | 225 | 44104 |
Peter Nijkamp | 97 | 2407 | 50826 |
Nicola Neri | 92 | 1122 | 41986 |
Ursula Keller | 92 | 934 | 33229 |
A. Rizzi | 91 | 653 | 40038 |
Martin J. Blunt | 89 | 485 | 29225 |