Institution
University of Córdoba (Spain)
Education•Cordova, Spain•
About: University of Córdoba (Spain) is a education organization based out in Cordova, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 12006 authors who have published 22998 publications receiving 537842 citations. The organization is also known as: University of Córdoba (Spain) & Universidad de Córdoba.
Papers published on a yearly basis
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TL;DR: Better results have been obtained with the proposed method in terms of rapidity, efficiency, cleanliness and possibility of manipulating the composition of the extract.
158 citations
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TL;DR: Detailed analyses of the genomic organization and functional characteristics of kiss/kisspeptins and gpr54 in different non-mammalian species, including fish, reptiles and amphibians have substantiated the conserved, essential roles of kisspeptin in the control of reproduction and disclosed intriguing evolutionary aspects ofkisspePTins and their receptors.
158 citations
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Icahn School of Medicine at Mount Sinai1, Massachusetts Institute of Technology2, South Colombian University3, Harvard University4, Industrial University of Santander5, Universidade Federal de Minas Gerais6, Universidade Federal de Sergipe7, Mexican Social Security Institute8, Instituto Politécnico Nacional9, Faculdade de Medicina de São José do Rio Preto10, Oswaldo Cruz Foundation11, University of Pittsburgh12, Colorado State University13, University of Antioquia14, University of Córdoba (Spain)15, University of Colorado Denver16, All India Institute of Medical Sciences17, Translational Health Science and Technology Institute18, Central University of Venezuela19, University of Massachusetts Boston20
TL;DR: The characterization of monoclonal antibody pairs that have been translated into rapid immunochromatography tests to specifically detect the viral nonstructural 1 (NS1) protein antigen and distinguish the four DENV serotypes (DENV1–4) and ZIKV without cross-reaction are reported.
Abstract: The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. Because ZIKV and DENV are related flaviviruses, their homologous proteins and nucleic acids can cause cross-reactions and false-positive results in molecular, antigenic, and serologic diagnostics. We report the characterization of monoclonal antibody pairs that have been translated into rapid immunochromatography tests to specifically detect the viral nonstructural 1 (NS1) protein antigen and distinguish the four DENV serotypes (DENV1-4) and ZIKV without cross-reaction. To complement visual test analysis and remove user subjectivity in reading test results, we used image processing and data analysis for data capture and test result quantification. Using a 30-μl serum sample, the sensitivity and specificity values of the DENV1-4 tests and the pan-DENV test, which detects all four dengue serotypes, ranged from 0.76 to 1.00. Sensitivity/specificity for the ZIKV rapid test was 0.81/0.86, respectively, using a 150-μl serum input. Serum ZIKV NS1 protein concentrations were about 10-fold lower than corresponding DENV NS1 concentrations in infected patients; moreover, ZIKV NS1 protein was not detected in polymerase chain reaction-positive patient urine samples. Our rapid immunochromatography approach and reagents have immediate application in differential clinical diagnosis of acute ZIKV and DENV cases, and the platform can be applied toward developing rapid antigen diagnostics for emerging viruses.
157 citations
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University of Santiago de Compostela1, University of Barcelona2, University of the Basque Country3, University of Córdoba (Spain)4, University of Cambridge5, VTT Technical Research Centre of Finland6, University of Helsinki7, University of Iowa8, University of Massachusetts Medical School9, Howard Hughes Medical Institute10, International University Of Catalonia11, Åbo Akademi University12, University of Lübeck13, University of Turku14, Centro Nacional de Investigaciones Cardiovasculares15
TL;DR: The underlying pathways through which central T3 modulates peripheral metabolism are uncovered, finding that central triiodothyronine regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue through the parasympathetic and sympathetic nervous system respectively.
157 citations
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TL;DR: The genomic predictabilities of 35 key traits are reported and the potential of genomic selection for wheat end-use quality is demonstrated and the genotype–phenotype map is built, which can be used to enhance wheat productivity and stress resilience.
Abstract: Bread wheat improvement using genomic tools is essential for accelerating trait genetic gains. Here we report the genomic predictabilities of 35 key traits and demonstrate the potential of genomic selection for wheat end-use quality. We also performed a large genome-wide association study that identified several significant marker–trait associations for 50 traits evaluated in South Asia, Africa and the Americas. Furthermore, we built a reference wheat genotype–phenotype map, explored allele frequency dynamics over time and fingerprinted 44,624 wheat lines for trait-associated markers, generating over 7.6 million data points, which together will provide a valuable resource to the wheat community for enhancing productivity and stress resilience. Large-scale genomic analyses in wheat identify regions associated with 50 agronomic traits evaluated in South Asia, Africa and the Americas. This genotype–phenotype map can be used to enhance wheat productivity and stress resilience.
157 citations
Authors
Showing all 12089 results
Name | H-index | Papers | Citations |
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Jose M. Ordovas | 123 | 1024 | 70978 |
Liang Cheng | 116 | 1779 | 65520 |
Pedro W. Crous | 115 | 809 | 51925 |
Munther A. Khamashta | 109 | 623 | 50205 |
Luis Serrano | 105 | 452 | 42515 |
Raymond Vanholder | 103 | 841 | 40861 |
Carlos Dieguez | 101 | 545 | 36404 |
David G. Bostwick | 99 | 403 | 31638 |
Leon V. Kochian | 95 | 266 | 31301 |
Abhay Ashtekar | 94 | 366 | 37508 |
Néstor Armesto | 93 | 369 | 26848 |
Manuel Hidalgo | 92 | 538 | 41330 |
Rafael de Cabo | 91 | 317 | 35020 |
Harald Mischak | 90 | 445 | 27472 |
Manuel Tena-Sempere | 87 | 351 | 23100 |