University of Dundee

About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines

Abstract: A revision of the 2000 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in May 2006. Key areas in treating depression were reviewed, and the strength of evidence and clinical implications were considered. The guidelines were drawn up after extensive feedback from participants and interested parties. A literature review is provided, which identifies the quality of evidence to inform the recommendations, the strength of which are based on the level of evidence. These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse, and stopping treatment.

Interpretative phenomenological analysis: a discussion and critique.

Abstract: Aim The aim of this article is to examine the approach of interpretative phenomenological analysis (IPA) and to add to discussions regarding the contribution that the approach can make to healthcare research. Background Interpretative phenomenological analysis is an approach to qualitative, experiential research that has been gaining in momentum and popularity over the past 10-15 years. The approach has its roots in psychology and recognises the central role of the analyst in understanding the experiences of participants. IPA involves a two-stage interpretation process whereby the researcher attempts to interpret how the participants make sense of their experience. Data sources Interpretative phenomenological analysis is discussed and critiqued in relation to other phenomenological approaches; benefits, potential limitations and rigour of studies using the method are explored. Review methods This is a methodology discussion that compares and contrasts IPA with other phenomenological approaches. Conclusion Interpretative phenomenological analysis offers an adaptable and accessible approach to phenomenological research intended to give a complete and in-depth account that privileges the individual. It enables nurses to reach, hear and understand the experiences of participants. Findings from IPA studies can influence and contribute to theory. Implications for research and practice Achieving a greater understanding of experiences in health care and illness can improve service provision. It is only by understanding meanings that nurses can influence health behaviour and lifestyles.

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Abstract: Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 x 10(-5) were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one biologically relevant candidate gene, on chromosomes 20q13 (HNF4A; P = 3.2 x 10(-17)), 16q22 (CDH1 and CDH3; P = 2.8 x 10(-8)) and 7q31 (LAMB1; P = 3.0 x 10(-8)). Of note, CDH1 has recently been associated with susceptibility to colorectal cancer, an established complication of longstanding ulcerative colitis. The new associations suggest that changes in the integrity of the intestinal epithelial barrier may contribute to the pathogenesis of ulcerative colitis.