Institution
University of Dundee
Education•Dundee, United Kingdom•
About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.
Papers published on a yearly basis
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TL;DR: In this paper, the efficiency of use of Fe and Mo in growth of organisms growing with different mixtures of the major resources photons, carbon and nitrogen, was investigated for growth with different nitrogen sources in the presence of constant photon and carbon availability.
Abstract: SUMMARY
Iron has many catalytic roles in photosynthesis, respiration and nitrogen assimilation; molybdenum is involved in NO3 and (usually) N2 reduction. This paper concentrates on computing the efficiency of use of Fe and Mo in growth of organisms growing with different mixtures of the major resources photons, carbon and nitrogen. This computed efficiency is defined as mol C assimilated (mol catalytic metal in the organism)-1 s-1. The efficiency is computed from the known in vivo involvement of Fe- and Mo-containing enzymes, the specific reaction rate of these enzymes, the specific rate of these enzymes in vitro, and the growth requirements for the products of the reactions, for organisms using different energy, carbon and nitrogen sources. The predicted Fe use efficiency is greater for chemo-organotrophic than for photolithotrophic growth with a given nitrogen source, and increases in the order N2 NO3- NH4+ for growth with different nitrogen sources in the presence of constant photon and carbon availability. The predicted changes with variations in nitrogen source are greater than those with variations in photon and carbon source. These predicted values may be compared with observed metal use efficiencies, defined as mol C assimilated (mol total metal in the organism)-1 s-1. Relatively few such observed values are available From the literature. For Fe in photolithotrophically growing microalgae the observed values can be as low as 16–17% of the predicted values, i.e. 83–84% of the Fe in the organism is not accounted for by known catalytic uses of Fe if the catalysts are operating at their maximum specific reaction rates. One possibly discordant prediction relates to the Fe and Mo cost of N2 fixation; the computations suggest that in vitro estimates of nitrogenase activity may be less than those sometimes found in vivo. The predictions also have possible implications for resource availability interactions (photons, carbon, nitrogen, Fe, Mo) in natural conditions.
403 citations
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TL;DR: The structure of PP1 provides insight into the molecular mechanism for substrate recognition, enzyme regulation and inhibition of this enzyme by toxins and tumour promoters and a basis for understanding the expanding family of related phosphatases which include PP2A and PP2B (calcineurin).
403 citations
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TL;DR: Kraft pulping of tree trunks showed that the reduced-CAD lines had improved characteristics, allowing easier delignification, using smaller amounts of chemicals, while yielding more high-quality pulp, highlighting the potential of engineering wood quality for more environmentally benign papermaking without interfering with tree growth or fitness.
Abstract: The agronomic and pulping performance of transgenic trees with altered lignin has been evaluated in duplicated, long-term field trials. Poplars expressing cinnamyl alcohol dehydrogenase (CAD) or caffeate/5-hydroxyferulate O-methyltransferase (COMT) antisense transgenes were grown for four years at two sites, in France and England. The trees remained healthy throughout the trial. Growth indicators and interactions with insects were normal. No changes in soil microbial communities were detected beneath the transgenic trees. The expected modifications to lignin were maintained in the transgenics over four years, at both sites. Kraft pulping of tree trunks showed that the reduced-CAD lines had improved characteristics, allowing easier delignification, using smaller amounts of chemicals, while yielding more high-quality pulp. This work highlights the potential of engineering wood quality for more environmentally benign papermaking without interfering with tree growth or fitness.
403 citations
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TL;DR: These findings provide the first in vivo evidence that Pink1 is detectable at basal levels and that basal mammalian mitophagy occurs independently of PINK1, and suggest multiple, yet-to-be-discovered pathways orchestrating mammalian mitochondrial integrity in a context-dependent fashion.
403 citations
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TL;DR: The crystal structure of CHIP bound to an Hsp90 C-terminal decapeptide is determined and the structure explains how CHIP associates with either chaperone type and reveals an unusual asymmetric homodimer in which the protomers adopt radically different conformations.
402 citations
Authors
Showing all 19404 results
Name | H-index | Papers | Citations |
---|---|---|---|
Matthias Mann | 221 | 887 | 230213 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Stefan Schreiber | 178 | 1233 | 138528 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Salvador Moncada | 164 | 495 | 138030 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Andrew P. McMahon | 162 | 415 | 90650 |
Philip Cohen | 154 | 555 | 110856 |
Dirk Inzé | 149 | 647 | 74468 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Antonio Lanzavecchia | 145 | 408 | 100065 |
Kim Nasmyth | 142 | 294 | 59231 |
David Price | 138 | 1687 | 93535 |
Dario R. Alessi | 136 | 354 | 74753 |