University of New South Wales

About: University of New South Wales is a education organization based out in Sydney, New South Wales, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 51197 authors who have published 153634 publications receiving 4880608 citations. The organization is also known as: UNSW & UNSW Australia.

EMT, cell plasticity and metastasis

Abstract: Carcinoma cells that are induced to suppress their epithelial features and upregulate mesenchymal gene expression programs acquire traits that promote an invasive and metastatic phenotype. This is achieved through the expression of a program termed the epithelial-to-mesenchymal transition (EMT)-a fundamental cell-biological process that plays key roles in embryogenesis and wound healing. Re-activation of the EMT during cancer promotes disease progression and enhances the metastatic phenotype by bestowing upon previously benign carcinoma cell traits such as migration, invasion, resistance to anoikis, chemoresistance and tumour-initiating potential. Herein, we discuss recent insights into the function of the EMT and cancer cell plasticity during cancer progression, with a focus on their role in promoting successful completion of the later stages of the metastatic cascade.

Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein.

Abstract: Summary: Acylated homoserine lactone (AHL)-mediated gene expression controls phenotypes involved in colonization, often specifically of higher organisms, in both marine and terrestrial environments. The marine red alga Delisea pulchra produces halogenated furanones which resemble AHLs structurally and show inhibitory activity at ecologically realistic concentrations in AHL bioassays. Evidence is presented that halogenated furanones displace tritiated OHHL [N-3- (oxohexanoy1)-L-homoserine lactone] from Escherichia coli cells overproducing LuxR with potencies corresponding to their respective inhibitory activities in an AHL-regulated bioluminescence assay, indicating that this is the mechanism by which furanones inhibit AHL-dependent phenotypes. Alternative mechanisms for this phenomenon are also addressed. General metabolic disruption was assessed with two-dimensional PAGE, revealing limited non- AHL-related effects. A direct chemical interaction between the algal compounds and AHLs, as monitored by 1H NMR spectroscopy, was shown not to occur in vitro. These results support the contention that furanones, at the concentrations produced by the alga, can control bacterial colonization of surfaces by specifically interfering with AHL-mediated gene expression at the level of the LuxR protein.

The Future of Policing

Abstract: This essay examines the restructuring of policing currently taking place in developed democratic societies. It argues that restructuring is occurring under private as well as government auspices and will have profound effects on public safety, equity, human rights, and accountability. These effects are discussed, along with the trade-offs they represent for public policy. The driving forces behind restructuring are fear of crime, the inability of government to satisfy society's longing for security, the commodification of security, the rise of mass private property, and cultural individualism. The essay concludes with a prediction about the future of policing and suggests policies that are needed to avoid restructuring's harmful effects.

Cost of Virtual Machine Live Migration in Clouds: A Performance Evaluation

Abstract: Virtualization has become commonplace in modern data centers, often referred as "computing clouds". The capability of virtual machine live migration brings benefits such as improved performance, manageability and fault tolerance, while allowing workload movement with a short service downtime. However, service levels of applications are likely to be negatively affected during a live migration. For this reason, a better understanding of its effects on system performance is desirable. In this paper, we evaluate the effects of live migration of virtual machines on the performance of applications running inside Xen VMs. Results show that, in most cases, migration overhead is acceptable but cannot be disregarded, especially in systems where availability and responsiveness are governed by strict Service Level Agreements. Despite that, there is a high potential for live migration applicability in data centers serving modern Internet applications. Our results are based on a workload covering the domain of multi-tier Web 2.0 applications.