Showing papers by "University of New South Wales published in 2002"

Corporate reputation and sustained superior financial performance

Abstract: Good corporate reputations are critical because of their potential for value creation, but also because their intangible character makes replication by competing firms considerably more difficult. Existing empirical research confirms that there is a positive relationship between reputation and financial performance. This paper complements these findings by showing that firms with relatively good reputations are better able to sustain superior profit outcomes over time. In particular, we undertake an analysis of the relationship between corporate reputation and the dynamics of financial performance using two complementary dynamic models. We also decompose overall reputation into a component that is predicted by previous financial performance, and that which is ‘left over’, and find that each (orthogonal) element supports the persistence of above-average profits over time. Copyright © 2002 John Wiley & Sons, Ltd.

World report on violence and health

Abstract: In 1996, the World Health Assembly declared violence a major public health issue. To follow up on this resolution, on October 3 this year, WHO released the first World Report on Violence and Health. The report analyses different types of violence including child abuse and neglect, youth violence, intimate partner violence, sexual violence, elder abuse, self-directed violence, and collective violence. For all these types of violence, the report explores the magnitude of the health and social effects, the risk and protective factors, and the types of prevention efforts that have been initiated. The launch of the report will be followed by a 1-year Global Campaign on Violence Prevention, focusing on implementation of the recommendations. This article summarises some of the main points of the world report.

Neuregulin 1 and Susceptibility to Schizophrenia

Abstract: The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we report the results of a genomewide scan of schizophrenia families in Iceland; these results support previous work, done in five populations, showing that schizophrenia maps to chromosome 8p. Extensive fine-mapping of the 8p locus and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. NRG1 is expressed at central nervous system synapses and has a clear role in the expression and activation of neurotransmitter receptors, including glutamate receptors. Mutant mice heterozygous for either NRG1 or its receptor, ErbB4, show a behavioral phenotype that overlaps with mouse models for schizophrenia. Furthermore, NRG1 hypomorphs have fewer functional NMDA receptors than wild-type mice. We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia.

Performance Assessment of the Lead User Idea-Generation Process for New Product Development

Abstract: Traditional idea generation techniques based on customer input usually collect information on new product needs from a random or typical set of customers. The "lead user process" takes a different approach. It collects information about both needs and solutions from users at the leading edges of the target market, as well as from users in other markets that face similar problems in a more extreme form. This paper reports on a natural experiment conducted within the 3M Company on the effect of the lead user (LU) idea-generation process relative to more traditional methods. 3M is known for its innovation capabilities-- and we find that the LU process appears to improve upon those capabilities. Annual sales of LU product ideas generated by the average LU project at 3M are conservatively projected to be $146 million after five years--more than eight times higher than forecast sales for the average contemporaneously conducted "traditional" project. Each funded LU project is projected to create a new major product line for a 3M division. As a direct result, divisions funding LU project ideas are projecting their highest rate of major product line generation in the past 50 years.

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

Abstract: Novel molecular tools have been constructed which allow for in situ detection of N-acyl homoserine lactone (AHL)-mediated quorum sensing in Pseudomonas aeruginosa biofilms. The reporter responds to AHL activation of LasR by expression of an unstable version of the green-fluorescent protein (Gfp). Gfp-based reporter technology has been applied for non-destructive, single-cell-level detection of quorum sensing in laboratory-based P. aeruginosa biofilms. It is reported that a synthetic halogenated furanone compound, which is a derivative of the secondary metabolites produced by the Australian macroalga Delisea pulchra, is capable of interfering with AHL-mediated quorum sensing in P. aeruginosa. It is demonstrated that the furanone compound specifically represses expression of a PlasB-gfp reporter fusion without affecting growth or protein synthesis. In addition, it reduces the production of important virulence factors, indicating a general effect on target genes of the las quorum sensing circuit. The furanone was applied to P. aeruginosa biofilms established in biofilm flow chambers. The Gfp-based analysis reveals that the compound penetrates microcolonies and blocks cell signalling and quorum sensing in most biofilm cells. The compound did not affect initial attachment to the abiotic substratum. It does, however, affect the architecture of the biofilm and enhances the process of bacterial detachment, leading to a loss of bacterial biomass from the substratum.

Does conversion of forest to agricultural land change soil carbon and nitrogen? a review of the literature

Abstract: Soil carbon is a large component of the global carbon cycle and its management can significantly affect the atmospheric CO2 concentration. An important management issue is the extent of soil carbon (C) release when forest is converted to agricultural land. We reviewed the literature to assess changes in soil C upon conversion of forests to agricultural land. Analyses are confounded by changes in soil bulk density upon land-use change, with agricultural soils on average having 13% higher bulk density. Consistent with earlier reviews, we found that conversion of forest to cultivated land led to an average loss of approximately 30% of soil C. When we restricted our analysis to studies that had used appropriate corrections for changes in bulk density, soil C loss was 22%. When, from all the studies compiled, we considered only studies reporting both soil C and nitrogen (N), average losses of C and N were 24% and 15%, respectively, hence showing a decrease in the average C : N ratio. The magnitude of these changes in the C : N ratio did not correlate with either C or N changes. When considering the transition from forest to pasture, there was no significant change in either soil C or N, even though reported changes in soil C ranged from −50% to +160%. Among studies that reported changes in soil N as well as soil C, C : N ratios both increased and decreased, with trends depending on changes in system N. Systems with increasing soil N generally had decreased C : N ratios, whereas systems with decreasing soil N had increased C : N ratios. Our survey confirmed earlier findings that conversion of forest to cropland generally leads to a loss of soil carbon, although the magnitude of change might have been inflated in many studies by the confounding influence of bulk-density changes. In contrast, conversion of forest to uncultivated grazing land did not, on average, lead to loss of soil carbon, although individual sites may lose or gain soil C, depending on specific circumstances, such as application of fertiliser or retention or removal of plant residues.

Bäcklund and Darboux transformations : geometry and modern applications in soliton theory

Abstract: This book describes the remarkable connections that exist between the classical differential geometry of surfaces and modern soliton theory. The authors also explore the extensive body of literature from the nineteenth and early twentieth centuries by such eminent geometers as Bianchi, Darboux, Backlund, and Eisenhart on transformations of privileged classes of surfaces which leave key geometric properties unchanged. Prominent amongst these are Backlund-Darboux transformations with their remarkable associated nonlinear superposition principles and importance in soliton theory. It is with these transformations and the links they afford between the classical differential geometry of surfaces and the nonlinear equations of soliton theory that the present text is concerned. In this geometric context, solitonic equations arise out of the Gaus-Mainardi-Codazzi equations for various types of surfaces that admit invariance under Backlund-Darboux transformations. This text is appropriate for use at a higher undergraduate or graduate level for applied mathematicians or mathematical physics.

Temperature response of parameters of a biochemically based model of photosynthesis. II. A review of experimental data

Abstract: The temperature dependence of C 3 photosynthesis is known to vary with growth environment and with species In an attempt to quantify this variability, a commonly used biochemically based photosynthesis model was parameterized from 19 gas exchange studies on tree and crop species The parameter values obtained described the shape and amplitude of the temperature responses of the maximum rate of Rubisco activity ( V cmax ) and the potential rate of electron transport ( J max ) Original data sets were used for this review, as it is shown that derived values of V cmax and its temperature response depend strongly on assumptions made in derivation Values of J max and V cmax at 25 ° C varied considerably among species but were strongly correlated, with an average J max : V cmax ratio of 1·67 Two species grown in cold climates, however, had lower ratios In all studies, the J max : V cmax ratio declined strongly with measurement temperature The relative temperature responses of J max and V cmax were relatively constant among tree species Activation energies averaged 50 kJ mol − 1 for J max and 65 kJ mol − − − 1 for V cmax , and for most species temperature optima averaged 33 ° ° ° C for J max and 40 ° C for V cmax However, the cold climate tree species had low temperature optima for both J max ( 19 ° C) and V cmax (29 ° ° ° C), suggesting acclimation of both processes to growth temperature Crop species had somewhat different temperature responses, with higher activation energies for both J max and V cmax , implying narrower peaks in the temperature response for these species The results thus suggest that both growth environment and

Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.

Abstract: Poor cell adhesion to orthopaedic and dental implants may result in implant failure. Cellular adhesion to biomaterial surfaces primarily is mediated by integrins, which act as signal transduction and adhesion proteins. Because integrin function depends on divalent cations, we investigated the effect of magnesium ions modified bioceramic substrata (Al(2)O(3)-Mg(2+)) on human bone-derived cell (HBDC) adhesion, integrin expression, and activation of intracellular signalling molecules. Immunohistochemistry, flow cytometry, cell adhesion, cell adhesion blocking, and Western blotting assays were used. Our findings demonstrated that adhesion of HBDC to Al(2)O(3)-Mg(2+) was increased compared to on the Mg(2+)-free Al(2)O(3). Furthermore, HBDC adhesion decreased significantly when the fibronectin receptor alpha5beta1- and beta1-integrins were blocked by functional blocking antibodies. HBDC grown on the Mg(2+)-modified bioceramic expressed significantly enhanced levels of beta1-, alpha5beta1-, and alpha3beta1-integrins receptors compared to those grown on the native unmodified Al(2)O(3). Tyrosine phosphorylation of intracellular integrin-dependent signalling proteins as well as the expression of key signalling protein Shc isoforms (p46, p52, p66), focal adhesion kinase, and extracellular matrix protein collagen type I were significantly enhanced when HBDC were grown on Al(2)O(3)-Mg(2+) compared to the native Al(2)O(3). We conclude that cell adhesion to biomaterial surfaces is probably mediated by alpha5beta1- and beta1-integrin. Cation-promoted cell adhesion depends on 5beta1- and beta1-integrins associated signal transduction pathways involving the key signalling protein Shc and results also in enhanced gene expression of extracellular matrix proteins. Therefore, Mg(2+) supplementation of bioceramic substrata may be a promising way to improve integration of implants in orthopaedic and dental surgery.

The 2dF Galaxy Redshift Survey: The environmental dependence of galaxy star formation rates near clusters

Abstract: We have measured the equivalent width of the Hα emission line for 11 006 galaxies brighter than M_b-=-−19 (Ω_Λ = 0.7, Ω_m = 0.3, H_0 = 70 km s^(−1) Mpc^(−1)) at 0.05 < z < 0.1 in the 2dF Galaxy Redshift Survey (2dFGRS), in the fields of 17 known galaxy clusters. The limited redshift range ensures that our results are insensitive to aperture bias, and to residuals from night sky emission lines. We use these measurements to trace μ*, the star formation rate normalized to L*, as a function of distance from the cluster centre, and local projected galaxy density. We find that the distribution of μ* steadily skews toward larger values with increasing distance from the cluster centre, converging to the field distribution at distances greater than ∼3 times the virial radius. A correlation between star formation rate and local projected density is also found, which is independent of cluster velocity dispersion and disappears at projected densities below ∼1 galaxy Mpc^(−2) (brighter than M_b = −19). This characteristic scale corresponds approximately to the mean density at the cluster virial radius. The same correlation holds for galaxies more than two virial radii from the cluster centre. We conclude that environmental influences on galaxy properties are not restricted to cluster cores, but are effective in all groups where the density exceeds this critical value. The present-day abundance of such systems, and the strong evolution of this abundance, makes it likely that hierarchical growth of structure plays a significant role in decreasing the global average star formation rate. Finally, the low star formation rates well beyond the virialized cluster rule out severe physical processes, such as ram pressure stripping of disc gas, as being completely responsible for the variations in galaxy properties with environment.

Enhancement of the critical current density and flux pinning of MgB2 superconductor by nanoparticle SiC doping

Abstract: Doping of MgB2 by nano-SiC and its potential for improvement of flux pinning was studied for MgB2-x(SiC)x/2 with x = 0, 0.2 and 0.3 and a 10wt% nano-SiC doped MgB2 samples. Co-substitution of B by Si and C counterbalanced the effects of single-element doping, decreasing Tc by only 1.5K, introducing pinning centres effective at high fields and temperatures and enhancing Jc and Hirr significantly. Compared to the non-doped sample, Jc for the 10wt% doped sample increased by a factor of 32 at 5K and 8T, 42 at 20K and 5T, and 14 at 30K and 2T. At 20K, which is considered to be a benchmark operating temperature for MgB2, the best Jc for the doped sample was 2.4x10^5A/cm2 at 2T, which is comparable to Jc of the best Ag/Bi-2223 tapes. At 20K and 4T, Jc was 36,000A/cm2, which was twice as high as for the best MgB2 thin films and an order of magnitude higher than for the best Fe/MgB2 tapes. Because of such high performance, it is anticipated that the future MgB2 conductors will be made using the formula of MgBxSiyCz instead of the pure MgB2.

The 2dF Galaxy Redshift Survey: The bias of galaxies and the density of the Universe

Abstract: We compute the bispectrum of the 2dF Galaxy Redshift Survey (2dFGRS) and use it to measure the bias parameter of the galaxies. This parameter quantifies the strength of clustering of the galaxies relative to the mass in the Universe. By analysing 80 x 10 6 triangle configurations in the wavenumber range 0.1 < k < 0.5 h Mpc - 1 (i.e. on scales roughly between 5 and 30 h - 1 Mpc) we find that the linear bias parameter is consistent with unity: b 1 = 1.04 ′ 0.11, and the quadratic (non-linear) bias is consistent with zero: b 2 = -0.054 ′ 0.08. Thus, at least on large scales, optically selected galaxies do indeed trace the underlying mass distribution. The bias parameter can be combined with the 2dFGRS measurement of the redshift distortion parameter β ≃ Ω 0 . 6 m /b 1 , to yield Ωm = 0.27 ′0.06 for the matter density of the Universe, a result that is determined entirely from this survey, independent of other data sets. Our measurement of the matter density of the Universe should be interpreted as Ω m at the effective redshift of the survey (z = 0.17).

Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover.

Abstract: N-acyl-L-homoserine lactones (AHLs) are co-regulatory ligands required for control of the expression of genes encoding virulence traits in many Gram-negative bacterial species. Recent studies have indicated that AHLs modulate the cellular concentrations of LuxR-type regulatory proteins by binding and fortifying these proteins against proteolytic degradation (Zhu & Winans, 2001 R43 ). Halogenated furanones produced by the macroalga Delisea pulchra inhibit AHL-dependent gene expression. This study assayed for an in vivo interaction between a tritiated halogenated furanone and the LuxR protein of Vibrio fischeri overproduced in Escherichia coli. Whilst a stable interaction between the algal metabolite and the bacterial protein was not found, it was noted by Western analysis that the half-life of the protein is reduced up to 100-fold in the presence of halogenated furanones. This suggests that halogenated furanones modulate LuxR activity but act to destabilize, rather than protect, the AHL-dependent transcriptional activator. The furanone-dependent reduction in the cellular concentration of the LuxR protein was associated with a reduction in expression of a plasmid encoded P luxI –gfp(ASV) fusion suggesting that the reduction in LuxR concentration is the mechanism by which furanones control expression of AHL-dependent phenotypes. The mode of action by which halogenated furanones reduce cellular concentrations of the LuxR protein remains to be characterized.

Inverters for single-phase grid connected photovoltaic systems-an overview

Abstract: An overview on developments and a summary of the state-of-the-art of inverter technology in Europe for single-phase grid-connected photovoltaic (PV) systems for power levels up to 5 kW is provided in this paper. The information includes details not only on the topologies commercially available but also on the switching devices employed and the associated switching frequencies, efficiency, price trends and market share. Finally, the paper outlines issues associated with the development of relevant international industry standards affecting PV inverter technology.

Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.

Abstract: In cell-free Pseudomonas aeruginosa culture supernatants, we identified two compounds capable of activating an N-acylhomoserine lactone (AHL) biosensor. Mass spectrometry and NMR spectroscopy revealed that these compounds were not AHLs but the diketopiperazines (DKPs), cyclo(ΔAla-l-Val) and cyclo(l-Pro-l-Tyr) respectively. These compounds were also found in cell-free supernatants from Proteus mirabilis, Citrobacter freundii and Enterobacter agglomerans [cyclo(ΔAla-l-Val) only]. Although both DKPs were absent from Pseudomonas fluorescens and Pseudomonas alcaligenes, we isolated, from both pseudomonads, a third DKP, which was chemically characterized as cyclo(l-Phe-l-Pro). Dose–response curves using a LuxR-based AHL biosensor indicated that cyclo(ΔAla-l-Val), cyclo(l-Pro-l-Tyr) and cyclo(l-Phe-l-Pro) activate the biosensor in a concentration-dependent manner, albeit at much higher concentrations than the natural activator N-(3-oxohexanoyl)-l-homoserine lactone (3-oxo-C6-HSL). Competition studies showed that cyclo(ΔAla-l-Val), cyclo(l-Pro-l-Tyr) and cyclo(l-Phe-l-Pro) antagonize the 3-oxo-C6-HSL-mediated induction of bioluminescence, suggesting that these DKPs may compete for the same LuxR-binding site. Similarly, DKPs were found to be capable of activating or antagonizing other LuxR-based quorum-sensing systems, such as the N-butanoylhomoserine lactone-dependent swarming motility of Serratia liquefaciens. Although the physiological role of these DKPs has yet to be established, their activity suggests the existence of cross talk among bacterial signalling systems.

Characterization of CD4(+) CTLs ex vivo.

Abstract: The cytotoxic potential of CD8 + T cells and NK cells plays a crucial role in the immune response to pathogens. Although in vitro studies have reported that CD4 + T cells are also able to mediate perforin-mediated killing, the in vivo existence and relevance of cytotoxic CD4 + T cells have been the subject of debate. Here we show that a population of CD4 + perforin + T cells is present in the circulation at low numbers in healthy donors and is markedly expanded in donors with chronic viral infections, in particular HIV infection, at all stages of the disease, including early primary infection. Ex vivo analysis shows that these cells have cytotoxic potential mediated through the release of perforin. In comparison with more classical CD4 + T cells, this subset displays a distinct surface phenotype and functional profile most consistent with end-stage differentiated T cells and include Ag experienced CD4 + T cells. The existence of CD4 + cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response.

The 2dF Galaxy Redshift Survey: the dependence of galaxy clustering on luminosity and spectral type

Abstract: We investigate the dependence of galaxy clustering on luminosity and spectral type using the 2dF Galaxy Redshift Survey (2dFGRS). Spectral types are assigned using the principal-component analysis of Madgwick et al. We divide the sample into two broad spectral classes: galaxies with strong emission lines ('late types') and more quiescent galaxies ('early types'). We measure the clustering in real space, free from any distortion of the clustering pattern owing to peculiar velocities, for a series of volume-limited samples. The projected correlation functions of both spectral types are well described by a power law for transverse separations in the range 2<(σ/h-1 Mpc)<15, with a marginally steeper slope for early types than late types. Both early and late types have approximately the same dependence of clustering strength on luminosity, with the clustering amplitude increasing by a factor of 2.5 between L* and 4L*. At all luminosities, however, the correlation function amplitude for the early types is 50 per cent higher than that of the late types. These results support the view that luminosity, and not type, is the dominant factor in determining how the clustering strength of the whole galaxy population varies with luminosity.

Modelling lane changing and merging in microscopic traffic simulation

Abstract: This paper introduces Simulation of Intelligent TRAnsport Systems (SITRAS), a massive multi-agent simulation system in which driver-vehicle objects are modelled as autonomous agents. The simulation outputs can be used for the evaluation of Intelligent Transport Systems applications such as congestion and incident management, public transport priority and dynamic route guidance. The model concepts and specifications, and the first applications of the model in the area of incident modelling in urban arterial networks were described in previous publications. This paper presents the details of the lane changing and merging algorithms developed for the SITRAS model. These models incorporate procedures for ‘forced’ and ‘co-operative’ lane changing which are essential for lane changing under congested (and incident-affected) traffic conditions. The paper describes the algorithms and presents simulation examples to demonstrate the effects of the implemented models. The results indicate that only the forced and cooperative lane changing models can produce realistic flow-speed relationships during congested conditions.