Institution
University of Oklahoma
Education•Norman, Oklahoma, United States•
About: University of Oklahoma is a education organization based out in Norman, Oklahoma, United States. It is known for research contribution in the topics: Population & Radar. The organization has 25269 authors who have published 52609 publications receiving 1821706 citations. The organization is also known as: OU & Oklahoma University.
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TL;DR: An algorithm utilizing HE4 and CA125 successfully classified patients into high and low risk groups with 93.8% of EOC correctly classified as high risk, which can be used to effectively triage patients to centers of excellence.
737 citations
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01 May 2008TL;DR: In this article, a guide to the use of inverse theory for estimation and conditional simulation of flow and transport parameters in porous media is presented. Butler et al. describe the theory and practice of estimating properties of underground petroleum reservoirs from measurements of flow in wells and explain how to characterize the uncertainty in such estimates.
Abstract: This book is a guide to the use of inverse theory for estimation and conditional simulation of flow and transport parameters in porous media. It describes the theory and practice of estimating properties of underground petroleum reservoirs from measurements of flow in wells, and it explains how to characterize the uncertainty in such estimates. Early chapters present the reader with the necessary background in inverse theory, probability and spatial statistics. The book demonstrates how to calculate sensitivity coefficients and the linearized relationship between models and production data. It also shows how to develop iterative methods for generating estimates and conditional realizations. The text is written for researchers and graduates in petroleum engineering and groundwater hydrology, and can be used as a textbook for advanced courses on inverse theory in petroleum engineering. It includes many worked examples to demonstrate the methodologies and a selection of exercises.
734 citations
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TL;DR: Monotherapy with metformin was associated with durable glycemic control in approximately half of children and adolescents with recent-onset type 2 diabetes and the addition of rosiglitazone, but not an intensive lifestyle intervention, was superior to meetformin alone.
Abstract: Background Despite the increasing prevalence of type 2 diabetes in youth, there are few data to guide treatment. We compared the efficacy of three treatment regimens to achieve durable glycemic control in children and adolescents with recent-onset type 2 diabetes. Methods Eligible patients 10 to 17 years of age were treated with metformin (at a dose of 1000 mg twice daily) to attain a glycated hemoglobin level of less than 8% and were randomly assigned to continued treatment with metformin alone or to metformin combined with rosiglitazone (4 mg twice a day) or a lifestyle-intervention program focusing on weight loss through eating and activity behaviors. The primary outcome was loss of glycemic control, defined as a glycated hemoglobin level of at least 8% for 6 months or sustained metabolic decompensation requiring insulin. Results Of the 699 randomly assigned participants (mean duration of diagnosed type 2 diabetes, 7.8 months), 319 (45.6%) reached the primary outcome over an average follow-up of 3.86 years. Rates of failure were 51.7% (120 of 232 participants), 38.6% (90 of 233), and 46.6% (109 of 234) for metformin alone, metformin plus rosiglitazone, and metformin plus lifestyle intervention, respectively. Metformin plus rosiglitazone was superior to metformin alone (P=0.006); metformin plus lifestyle intervention was intermediate but not significantly different from metformin alone or metformin plus rosiglitazone. Prespecified analyses according to sex and race or ethnic group showed differences in sustained effectiveness, with metformin alone least effective in non-Hispanic black participants and metformin plus rosiglitazone most effective in girls. Serious adverse events were reported in 19.2% of participants. Conclusions Monotherapy with metformin was associated with durable glycemic control in approximately half of children and adolescents with type 2 diabetes. The addition of rosiglitazone, but not an intensive lifestyle intervention, was superior to metformin alone. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; TODAY ClinicalTrials.gov number, NCT00081328.).
731 citations
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TL;DR: Effective control of multiple-drug resistantEnterococci will require better understanding of the interaction between enterococci, the hospital environment, and humans, 2) prudent antibiotic use, 3) better contact isolation in hospitals and other patient care environments, and 4) improved surveillance.
Abstract: Enterococci, leading causes of nosocomial bacteremia, surgical wound infection, and urinary tract infection, are becoming resistant to many and sometimes all standard therapies. New rapid surveillance methods are highlighting the importance of examining enterococcal isolates at the species level. Most enterococcal infections are caused by Enterococcus faecalis, which are more likely to express traits related to overt virulence but--for the moment--also more likely to retain sensitivity to at least one effective antibiotic. The remaining infections are mostly caused by E. faecium, a species virtually devoid of known overt pathogenic traits but more likely to be resistant to even antibiotics of last resort. Effective control of multiple-drug resistant enterococci will require 1) better understanding of the interaction between enterococci, the hospital environment, and humans, 2) prudent antibiotic use, 3) better contact isolation in hospitals and other patient care environments, and 4) improved surveillance. Equally important is renewed vigor in the search for additional drugs, accompanied by the evolution of new therapeutic paradigms less vulnerable to the cycle of drug introduction and drug resistance.
728 citations
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TL;DR: In this paper, the authors take a step back and ask "How lumpy is investment?" by documenting the distributions of investment and capital adjustment for a sample of over 13,700 manufacturing plants drawn from over 300 four-digit industries.
723 citations
Authors
Showing all 25490 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Kessler | 274 | 1332 | 328983 |
Michael A. Strauss | 185 | 1688 | 208506 |
Derek R. Lovley | 168 | 582 | 95315 |
Ashok Kumar | 151 | 5654 | 164086 |
Peter J. Schwartz | 147 | 647 | 107695 |
Peter Buchholz | 143 | 1181 | 92101 |
Robert Hirosky | 139 | 1697 | 106626 |
Elizabeth Barrett-Connor | 138 | 793 | 73241 |
Brad Abbott | 137 | 1566 | 98604 |
Lihong V. Wang | 136 | 1118 | 72482 |
Itsuo Nakano | 135 | 1539 | 97905 |
Phillip Gutierrez | 133 | 1391 | 96205 |
P. Skubic | 133 | 1573 | 97343 |
Elizaveta Shabalina | 133 | 1421 | 92273 |
Richard Brenner | 133 | 1108 | 87426 |