University of Patras

About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.

Textile reinforced mortar (trm) versus frp as strengthening material of urm walls: out-of-plane cyclic loading

Abstract: In this study the application of a new structural material, namely textile-reinforced mortar (TRM), as a means of increasing the load carrying capacity and deformability of unreinforced masonry walls subjected to cyclic in-plane loading is experimentally investigated. The application of externally bonded TRM is considered in this work as an alternative method to the application of fiber-reinforced polymers (FRP). Hence, the effectiveness of TRM overlays is evaluated in comparison to the one provided by FRPs. Medium-scale tests were carried out on 22 masonry walls subjected to in-plane cyclic loading. Three types of specimens were used: (a) shear walls; (b) beam-columns; and (c) beams. The parameters under investigation included the matrix material (mortar versus resin), the number of textile layers and the compressive stress level applied to shear walls and beam-columns. Compared with their resin-impregnated counterparts, mortar-impregnated textiles may result in generally lower effectiveness in terms of strength, but in much higher in terms of deformability. From the results obtained in this study it is believed that TRMs hold strong promise as a solution for the structural upgrading of masonry structures under in-plane loading.

Pounding of buildings in series during earthquakes

Abstract: A simplified model of several adjacent buildings in a block is used to study the pounding of such buildings due to strong earthquakes. Considerable structural damage and even some collapses have sometimes been attributed to this effect. Each structure is modelled as a S.D.O.F. system and pounding is simulated using impact elements. A parametric investigation of this problem shows that the end structures experience almost always substantial increases in their response while for ‘interior’ structures the opposite often happens. This may explain why high percentages of corner buildings have collapsed in some earthquakes.

Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery.

Abstract: The preparation, properties and potential applications in drug delivery of biocompatible and biodegradable PLA-PEG and PLGA-PEG nanoparticles are discussed. PLA-PEG and PLGA-PEG nanoparticles have been produced by emulsification-solvent evaporation, solvent displacement and salting out methods. The nanoparticles can be stored as freeze-dried powders, but an adequate amount of a suitable lyoprotectant should be added prior lyophilisation to prevent nanoparticle aggregation and retain nanoparticle redispersibility. The nanoparticles have a core-shell structure with a PLA core and a PEG coating. Their basic colloidal properties and degradation depend on copolymer composition. The PLA-PEG and PLGA-PEG nanoparticles exhibit prolonged blood circulation following intravenous administration to animals. The composition of the nanoparticles determine their biodistribution properties, probably through its effects on the effectiveness of the PEG steric barrier and the size of the nanoparticles. The ability of the PLA-PEG and PLGA-PEG nanoparticles to evade rapid phagocytocis has extended the range of sites within the body that the nanoparticles can reach, which has significant implications with regard to their application in controlled drug delivery and targeting. The PLA-PEG and PLGA-PEG nanoparticles can be loaded with a variety of bioactive agents achieving satisfactory loading, especially in the case of hydrophobic drugs. The nanoparticles have been investigated for the treatment of infectious diseases and cancer, the intravenous and mucosal delivery of proteins, and oligonucleotide and gene delivery. The results have been encouraging and PLA-PEG and PLGA-PEG nanoparticle formulations, improving the therapeutic potential of both established and new drugs, may be expected to be available in the near future.