Institution
University of Queensland
Education•Brisbane, Queensland, Australia•
About: University of Queensland is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 51138 authors who have published 155721 publications receiving 5717659 citations. The organization is also known as: UQ & The University of Queensland.
Papers published on a yearly basis
Papers
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TL;DR: A simple extension of a sparse PLS exploratory approach is proposed to perform variable selection in a multiclass classification framework and has a classification performance similar to other wrapper or sparse discriminant analysis approaches on public microarray and SNP data sets.
Abstract: Variable selection on high throughput biological data, such as gene expression or single nucleotide polymorphisms (SNPs), becomes inevitable to select relevant information and, therefore, to better characterize diseases or assess genetic structure. There are different ways to perform variable selection in large data sets. Statistical tests are commonly used to identify differentially expressed features for explanatory purposes, whereas Machine Learning wrapper approaches can be used for predictive purposes. In the case of multiple highly correlated variables, another option is to use multivariate exploratory approaches to give more insight into cell biology, biological pathways or complex traits. A simple extension of a sparse PLS exploratory approach is proposed to perform variable selection in a multiclass classification framework. sPLS-DA has a classification performance similar to other wrapper or sparse discriminant analysis approaches on public microarray and SNP data sets. More importantly, sPLS-DA is clearly competitive in terms of computational efficiency and superior in terms of interpretability of the results via valuable graphical outputs. sPLS-DA is available in the R package mixOmics, which is dedicated to the analysis of large biological data sets.
672 citations
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TL;DR: Several shortcomings of the neurosphere assay related to its application and interpretation are highlighted that are believed to have led to a significant body of research whose conclusions may well be misleading.
Abstract: For most of the past century, the prospect of replacing lost or damaged cells in the central nervous system (CNS) was hampered by the opinion that the adult mammalian CNS was incapable of generating new nerve cells. This belief, like most dogmas, was essentially founded on a lack of experimental evidence to the contrary. The overturning of this 'no new neuron' hypothesis began midway through the twentieth century with a series of reports documenting neurogenesis in the postnatal and adult brain, continued with the isolation and in vitro culture of neurogenic cells from the adult mammalian brain, and culminated in the discovery of a population of multipotent, self-renewing cells in the adult CNS (that is, bona fide neural stem cells). Although a variety of techniques were initially used, the neurosphere assay (NSA) rapidly emerged as the assay of choice and has since become a valuable tool for isolating, and understanding the biology of, embryonic and adult CNS stem cells. Like all technologies, it is not without its limitations. In this article we will highlight several shortcomings of the assay related to its application and interpretation that we believe have led to a significant body of research whose conclusions may well be misleading.
672 citations
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University of Toronto1, Princess Margaret Cancer Centre2, Queen's University3, Katholieke Universiteit Leuven4, Peter MacCallum Cancer Centre5, University of Newcastle6, University of Queensland7, Saitama Medical University8, University of Calgary9, University of Alberta10, Hamilton Health Sciences11, Pierre-and-Marie-Curie University12, Aix-Marseille University13, European Organisation for Research and Treatment of Cancer14, Heidelberg University15, Royal North Shore Hospital16, Maastricht University17
TL;DR: In elderly patients with glioblastoma, the addition of temozolomide to short‐course radiotherapy resulted in longer survival than short‐ Course radiotherapy alone.
Abstract: BackgroundGlioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter courses of radiotherapy are commonly used, but the benefit of adding temozolomide to a shorter course of radiotherapy is unknown. MethodsWe conducted a trial involving patients 65 years of age or older with newly diagnosed glioblastoma. Patients were randomly assigned to receive either radiotherapy alone (40 Gy in 15 fractions) or radiotherapy with concomitant and adjuvant temozolomide. ResultsA total of 562 patients underwent randomization, 281 to each group. The median age was 73 years (range, 65 to 90). The median overall survival was longer with radiotherapy plus temozolomide than with radiotherapy alone (9.3 months vs. 7.6 months; hazard ratio for death, 0.67; 95% confidence interval [CI], 0.56 to 0.80; P<0.0...
672 citations
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TL;DR: It is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.
Abstract: The accumulation of bone microdamage has been proposed as one factor that contributes to increased skeletal fragility with age and that may increase the risk for fracture in older women. This paper reviews the current status and understanding of microdamage physiology and its importance to skeletal fragility. Several questions are addressed: Does microdamage exist in vivo in bone? If it does, does it impair bone quality? Does microdamage accumulate with age, and is the accumulation of damage with age sufficient to cause a fracture? The nature of the damage repair mechanism is reviewed, and it is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.
671 citations
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TL;DR: The central premise of boson sampling was tested, experimentally verifying that three-photon scattering amplitudes are given by the permanents of submatrices generated from a unitary describing a six-mode integrated optical circuit.
Abstract: Quantum computers are unnecessary for exponentially efficient computation or simulation if the Extended Church-Turing thesis is correct. The thesis would be strongly contradicted by physical devices that efficiently perform tasks believed to be intractable for classical computers. Such a task is boson sampling: sampling the output distributions of n bosons scattered by some passive, linear unitary process. We tested the central premise of boson sampling, experimentally verifying that three-photon scattering amplitudes are given by the permanents of submatrices generated from a unitary describing a six-mode integrated optical circuit. We find the protocol to be robust, working even with the unavoidable effects of photon loss, non-ideal sources, and imperfect detection. Scaling this to large numbers of photons should be a much simpler task than building a universal quantum computer.
671 citations
Authors
Showing all 52145 results
Name | H-index | Papers | Citations |
---|---|---|---|
Graham A. Colditz | 261 | 1542 | 256034 |
George Davey Smith | 224 | 2540 | 248373 |
David J. Hunter | 213 | 1836 | 207050 |
Daniel Levy | 212 | 933 | 194778 |
Christopher J L Murray | 209 | 754 | 310329 |
Matthew Meyerson | 194 | 553 | 243726 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Nicholas G. Martin | 192 | 1770 | 161952 |
Paul M. Thompson | 183 | 2271 | 146736 |
Jie Zhang | 178 | 4857 | 221720 |
Alan D. Lopez | 172 | 863 | 259291 |
Ian J. Deary | 166 | 1795 | 114161 |
Steven N. Blair | 165 | 879 | 132929 |
Carlos Bustamante | 161 | 770 | 106053 |
David W. Johnson | 160 | 2714 | 140778 |