University of São Paulo

About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.

A bird's-eye view of density-functional theory

Abstract: This paper is the outgrowth of lectures the author gave at the Physics Institute and the Chemistry Institute of the University of Sao Paulo at Sao Carlos, Brazil, and at the VIII'th Summer School on Electronic Structure of the Brazilian Physical Society. It is an attempt to introduce density-functional theory (DFT) in a language accessible for students entering the field or researchers from other fields. It is not meant to be a scholarly review of DFT, but rather an informal guide to its conceptual basis and some recent developments and advances. The Hohenberg-Kohn theorem and the Kohn-Sham equations are discussed in some detail. Approximate density functionals, selected aspects of applications of DFT, and a variety of extensions of standard DFT are also discussed, albeit in less detail. Throughout it is attempted to provide a balanced treatment of aspects that are relevant for chemistry and aspects relevant for physics, but with a strong bias towards conceptual foundations. The paper is intended to be read before (or in parallel with) one of the many excellent more technical reviews available in the literature.

Modelling the Galactic Interstellar Extinction Distribution in Three Dimensions

Abstract: Aims. The Two Micron All Sky Survey, along with the Stellar Population Synthesis Model of the Galaxy, developed in Besancon, is used to calculate the extinction distribution along different lines of sight. By combining many lines of sight, the large scale distribution of interstellar material can be deduced. Methods. The Galaxy model is used to provide the intrinsic colour of stars and their probable distances, so that the near infrared colour excess, and hence the extinction, may be calculated and its distance evaluated. Such a technique is dependent on the model used, however we are able to show that moderate changes in the model parameters result in insignificant changes in the predicted extinction. Results. This technique has now been applied to over 64000 lines of sight, each separated by 15', in the inner Galaxy (|l| < 100°, |b| < 10°). We have projected our three dimensional results onto a two dimensional plane in order to compare them with existing two dimensional extinction maps and CO surveys. We find that although differences exist due to the different methods used or the medium traced, the same large scale structures are visible in each of the different maps. Using our extinction map, we have derived the main characteristics of the large scale structure of the dust distribution. The scale height of the interstellar matter is found to be 125 +17 -7 pc. The dust distribution is found to be asymmetrically warped, in agreement with CO and HI observations of the ISM. However, the slope of the dust warp and the galactocentric distance where it starts are found to be smaller than the values measured for the external HI disc: for positive longitudes the angle is 0 = 89°, it starts at 8.7 kpc from the Galactic center and grows with a slope of 0.14, while at negative longitudes, the angle of the maximum is at θ = 272°, the starting radius 7.8 kpc and the slope 0.11. Finally, the presence of dust is detected in the Galactic bulge. It forms an elongated structure approximately 5.2 kpc long and lies at an angle of 30 ± 5° with respect to the Sun-Galactic centre direction. This may be interpreted as a dust lane along the Galactic bar. This resulting extinction map will be useful for studies of the inner Galaxy and its stellar populations.

Ultra-Processed Food Products and Obesity in Brazilian Households (2008–2009)

Abstract: Background Production and consumption of industrially processed food and drink products have risen in parallel with the global increase in overweight and obesity and related chronic non-communicable diseases. The objective of this study was to analyze the relationship between household availability of processed and ultra-processed products and the prevalence of excess weight (overweight plus obesity) and obesity in Brazil. Methods The study was based on data from the 2008–2009 Household Budget Survey involving a probabilistic sample of 55,970 Brazilian households. The units of study were household aggregates (strata), geographically and socioeconomically homogeneous. Multiple linear regression models were used to assess the relationship between the availability of processed and ultra-processed products and the average of Body Mass Index (BMI) and the percentage of individuals with excess weight and obesity in the strata, controlling for potential confounders (socio-demographic characteristics, percentage of expenditure on eating out of home, and dietary energy other than that provided by processed and ultra-processed products). Predictive values for prevalence of excess weight and obesity were estimated according to quartiles of the household availability of dietary energy from processed and ultra-processed products. Results The mean contribution of processed and ultra-processed products to total dietary energy availability ranged from 15.4% (lower quartile) to 39.4% (upper quartile). Adjusted linear regression coefficients indicated that household availability of ultra-processed products was positively associated with both the average BMI and the prevalence of excess weight and obesity, whereas processed products were not associated with these outcomes. In addition, people in the upper quartile of household consumption of ultra-processed products, compared with those in the lower quartile, were 37% more likely to be obese. Conclusion Greater household availability of ultra-processed food products in Brazil is positively and independently associated with higher prevalence of excess weight and obesity in all age groups in this cross-sectional study.

Molecular mechanisms of glutamine action.

Abstract: Glutamine is the most abundant free amino acid in the body and is known to play a regulatory role in several cell specific processes including metabolism (e.g., oxidative fuel, gluconeogenic precursor, and lipogenic precursor), cell integrity (apoptosis, cell proliferation), protein synthesis, and degradation, contractile protein mass, redox potential, respiratory burst, insulin resistance, insulin secretion, and extracellular matrix (ECM) synthesis. Glutamine has been shown to regulate the expression of many genes related to metabolism, signal transduction, cell defense and repair, and to activate intracellular signaling pathways. Thus, the function of glutamine goes beyond that of a simple metabolic fuel or protein precursor as previously assumed. In this review, we have attempted to identify some of the common mechanisms underlying the regulation of glutamine dependent cellular functions.