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Institution

University of Tsukuba

EducationTsukuba, Ibaraki, Japan
About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.


Papers
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Journal ArticleDOI
04 Apr 2018-Nature
TL;DR: It is shown that the CLAVATA3/EMBRYO-SURROUNDing REGION-RELATED 25 (CLE25) peptide transmits water-deficiency signals through vascular tissues in Arabidopsis, and affects abscisic acid biosynthesis and stomatal control of transpiration in association with BARELY ANY MERISTEM (BAM) receptors in leaves.
Abstract: Mammalian peptide hormones propagate extracellular stimuli from sensing tissues to appropriate targets to achieve optimal growth maintenance 1 . In land plants, root-to-shoot signalling is important to prevent water loss by transpiration and to adapt to water-deficient conditions2, 3. The phytohormone abscisic acid has a role in the regulation of stomatal movement to prevent water loss 4 . However, no mobile signalling molecules have yet been identified that can trigger abscisic acid accumulation in leaves. Here we show that the CLAVATA3/EMBRYO-SURROUNDING REGION-RELATED 25 (CLE25) peptide transmits water-deficiency signals through vascular tissues in Arabidopsis, and affects abscisic acid biosynthesis and stomatal control of transpiration in association with BARELY ANY MERISTEM (BAM) receptors in leaves. The CLE25 gene is expressed in vascular tissues and enhanced in roots in response to dehydration stress. The root-derived CLE25 peptide moves from the roots to the leaves, where it induces stomatal closure by modulating abscisic acid accumulation and thereby enhances resistance to dehydration stress. BAM receptors are required for the CLE25 peptide-induced dehydration stress response in leaves, and the CLE25–BAM module therefore probably functions as one of the signalling molecules for long-distance signalling in the dehydration response.

332 citations

Journal ArticleDOI
TL;DR: A new protein is identified, which is named Keap1, that suppresses Nrf2 activity by specific binding to its evolutionarily-conserved N-terminal Neh2 regulatory domain.
Abstract: An antioxidant responsive element (ARE) or electrophile responsive element (EpRE) mediates the transcriptional activation of genes encoding phase II drug metabolizing enzymes. The ARE consensus sequence shows high similarity to an erythroid gene regulatory element, and based on the observation, we have recently found that transcription factor Nrf2 is essential for the coordinate induction of phase II detoxifying enzymes. The expression of anti-oxidative stress enzyme genes is also regulated by Nrf2. Detailed analysis of the regulatory mechanisms of Nrf2 activity has ultimately led us to the identification of a new protein, which we have named Keap1, that suppresses Nrf2 activity by specific binding to its evolutionarily-conserved N-terminal Neh2 regulatory domain.

330 citations

Journal ArticleDOI
TL;DR: Synthesis of cystine as y-glutamyl peptide and its use as a building block for peptide synthesis is continuing to be studied.

330 citations

Journal ArticleDOI
TL;DR: First-principles total-energy electronic-structure calculations in the density-functional theory performed for hexagonally bonded honeycomb sheets consisting of B, N, and C atoms find that the ground state of BNC sheets with particular stoichiometry is ferromagnetic.
Abstract: We report first-principles total-energy electronic-structure calculations in the density-functional theory performed for hexagonally bonded honeycomb sheets consisting of B, N, and C atoms. We find that the ground state of BNC sheets with particular stoichiometry is ferromagnetic. Detailed analyses of energy bands and spin densities unequivocally reveal the nature of the ferromagnetic ordering, leading to an argument that the BNC sheet is a manifestation of the flat-band ferromagnetism.

330 citations

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2944 moreInstitutions (220)
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...

329 citations


Authors

Showing all 36572 results

NameH-indexPapersCitations
Aaron R. Folsom1811118134044
Kazuo Shinozaki178668128279
Hyun-Chul Kim1764076183227
Masayuki Yamamoto1711576123028
Hua Zhang1631503116769
Lewis L. Lanier15955486677
David Cella1561258106402
Takashi Taniguchi1522141110658
Yoshio Bando147123480883
Kazuhiko Hara1411956107697
Janet Rossant13841671913
Christoph Paus1371585100801
Kohei Miyazono13551568706
Craig Blocker134137994195
Fumihiko Ukegawa133149294465
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023104
2022323
20214,079
20203,887
20193,515
20183,388