Institution
University of Tsukuba
Education•Tsukuba, Ibaraki, Japan•
About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.
Topics: Population, Gene, Catalysis, Superconductivity, Quantum chromodynamics
Papers published on a yearly basis
Papers
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TL;DR: An algorithm is proposed to estimate human intentions related to walking in order to comfortably and safely support a paraplegia patient's walk.
Abstract: This paper proposes an algorithm to estimate human intentions related to walking in order to comfortably and safely support a paraplegia patient's walk. Robot Suit HAL (Hybrid Assistive Limb) has been developed for enhancement of a healthy person's activities and for support of a physically challenged person's daily life. The assisting method based on bioelectrical signals such as myoelectricity successfully supports a healthy person's walking. These bioelectrical signals, however, cannot be measured properly from a paraplegia patient. Therefore another interface that can estimate a patient's intentions without any manual controller is desired for robot control since a manual controller deprives a patient of his/her hand freedom. Estimation of a patient's intentions contributes to providing not only comfortable support but also safe support, because any inconformity between the robot suit motion and the patient motion results in his/her stumbling or falling. The proposed algorithm estimates a patient's in...
437 citations
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TL;DR: This work examined the functions of the domains within Nrf2, a transcription factor essential for the antioxidant responsive element (ARE)‐mediated expression of a group of detoxifying and antioxidant genes.
Abstract: Background Nrf2 belongs to the Cap-N-Collar (CNC) transcription factor family and is essential for the antioxidant responsive element (ARE)-mediated expression of a group of detoxifying and antioxidant genes. The forced expression of Nrf2 in mammalian cells activates the expression of target genes through the ARE, with Nrf2 showing the highest transactivation activity among the CNC family of transcription factors. To elucidate the molecular mechanisms generating this potent transactivation activity, we examined the functions of the domains within Nrf2.
Result We found that Nrf2 contains two transcription activation domains, Neh4 and Neh5, which act synergistically to attain maximum a activation of reporter gene expression. Neh4 and Neh5 both individually and cooperatively bind to CBP (CREB (cAMP Responsive Element Binding protein) Binding Protein). In fact, the specific inhibitor of CBP, adenovirus E1A protein, significantly reduced Nrf2 activity. Importantly, the CBP-binding activity of Nrf2 deletion mutants positively correlated with their transactivation activity. Neh5 contains a motif which is commonly conserved among the CNC factors, whereas Neh4 contains the novel CBP-interacting motif recently identified in p53 and E2F.
Conclusions Our results indicate that Nrf2 exploits the cooperative binding of two independent transactivation domains to CBP in the acquisition of a potent transactivation activity.
436 citations
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University of London1, University of Queensland2, Monash University3, Potsdam Institute for Climate Impact Research4, Anhui Medical University5, Queensland University of Technology6, Shanghai Jiao Tong University7, University of São Paulo8, University of Ottawa9, University of Los Andes10, Fudan University11, Academy of Sciences of the Czech Republic12, Czech University of Life Sciences Prague13, University of Oulu14, Oulu University Hospital15, Dublin Institute of Technology16, Brunel University London17, Nagasaki University18, University of Tsukuba19, Kyoto University20, Seoul National University21, Spanish National Research Council22, University of Valencia23, Umeå University24, Lund University25, University of Basel26, Swiss Tropical and Public Health Institute27, National Taiwan University28, Harvard University29, Yale University30, Duy Tan University31, Ho Chi Minh City Medicine and Pharmacy University32, Public Health England33
TL;DR: In this article, the authors show that climate change can directly affect human health by varying exposure to non-optimal outdoor temperature, however, evidence on this direct impact at a global scale is limited.
436 citations
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TL;DR: In this paper, a Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) =.
Abstract: Differential measurements of charged particle azimuthal anisotropy are presented for lead-lead collisions at root sNN = 2.76 TeV with the ATLAS detector at the LHC, based on an integrated luminosity of approximately 8 mu b(-1). This anisotropy is characterized via a Fourier expansion of the distribution of charged particles in azimuthal angle relative to the reaction plane, with the coefficients v(n) denoting the magnitude of the anisotropy. Significant v(2)-v(6) values are obtained as a function of transverse momentum (0.5 = 3 are found to vary weakly with both eta and centrality, and their p(T) dependencies are found to follow an approximate scaling relation, v(n)(1/n)(p(T)) proportional to v(2)(1/2)(p(T)), except in the top 5% most central collisions. A Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) = . For pairs of charged particles with a large pseudorapidity gap (|Delta eta = eta(a) - eta(b)| > 2) and one particle with p(T) < 3 GeV, the v(2,2)-v(6,6) values are found to factorize as v(n,n)(p(T)(a), p(T)(b)) approximate to v(n) (p(T)(a))v(n)(p(T)(b)) in central and midcentral events. Such factorization suggests that these values of v(2,2)-v(6,6) are primarily attributable to the response of the created matter to the fluctuations in the geometry of the initial state. A detailed study shows that the v(1,1)(p(T)(a), p(T)(b)) data are consistent with the combined contributions from a rapidity-even v(1) and global momentum conservation. A two-component fit is used to extract the v(1) contribution. The extracted v(1) isobserved to cross zero at pT approximate to 1.0 GeV, reaches a maximum at 4-5 GeV with a value comparable to that for v(3), and decreases at higher p(T).
435 citations
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TL;DR: It is revealed that orexin neurons receive input from several brain areas, including the amygdala, basal forebrain cholinergic neurons, GABAergic neuron in the preoptic area, and serotonergic neurons in the median/paramedian raphe nuclei.
435 citations
Authors
Showing all 36572 results
Name | H-index | Papers | Citations |
---|---|---|---|
Aaron R. Folsom | 181 | 1118 | 134044 |
Kazuo Shinozaki | 178 | 668 | 128279 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Hua Zhang | 163 | 1503 | 116769 |
Lewis L. Lanier | 159 | 554 | 86677 |
David Cella | 156 | 1258 | 106402 |
Takashi Taniguchi | 152 | 2141 | 110658 |
Yoshio Bando | 147 | 1234 | 80883 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Janet Rossant | 138 | 416 | 71913 |
Christoph Paus | 137 | 1585 | 100801 |
Kohei Miyazono | 135 | 515 | 68706 |
Craig Blocker | 134 | 1379 | 94195 |
Fumihiko Ukegawa | 133 | 1492 | 94465 |