University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

Submarine Mass Movements and Their Consequences

Abstract: Submarine mass movements represent major offshore geohazards due to their destructive and tsunami-generation potential. This potential poses a threat to human life as well as to coastal, near shore and offshore engineering structures. Recent examples of catastrophic submarine landslide events that affected human populations (including tsunamis) are numerous; e.g., Nice airport in 1979 (Dan et al. 2007), Finneidfjord in 1996 (e.g., L’Heureux et al., this volume, Steiner et al., this volume), Papua-New Guinea in 1998 (Tappin et al. 2001), Stromboli in 2002 (Chiocci et al. 2008), and the 2006 and 2009 failures in the submarine cable network around Taiwan (Hsu et al. 2008). The Great East Japan Earthquake of March 2011 also generated submarine landslides that may have amplified effects of the devastating tsunami as shown in Fryer et al. (2004). Given that 30% of the World’s population lives within 60 km of the coast, the hazard posed by submarine landslides is expected to grow as global sea level rises. In addition, the deposits resulting from such processes provide-various types of constraints to offshore development (Shipp et al. 2004), and have significant implications for non-renewable energy resource exploration and production (Weimer and Shipp 2004; Beaubouef and Abreu 2010).

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

Abstract: Mice carrying mitochondrial DNA (mtDNA) with pathogenic mutations would provide a system in which to study how mutant mtDNAs are transmitted and distributed in tissues, resulting in expression of mitochondrial diseases. However, no effective procedures are available for the generation of these mice. Isolation of mouse cells without mtDNA (rho0) enabled us to trap mutant mtDNA that had accumulated in somatic tissues into rho0 cells repopulated with mtDNA (cybrids). We isolated respiration-deficient cybrids with mtDNA carrying a deletion and introduced this mtDNA into fertilized eggs. The mutant mtDNA was transmitted maternally, and its accumulation induced mitochondrial dysfunction in various tissues. Moreover, most of these mice died because of renal failure, suggesting the involvement of mtDNA mutations in the pathogeneses of new diseases.