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Institution

University of Tsukuba

EducationTsukuba, Ibaraki, Japan
About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.


Papers
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Journal ArticleDOI
01 Jun 2006-Nature
TL;DR: It is shown that sea surface temperatures near the North Pole increased from ∼18 °C to over 23‬°C during this event, which suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms—perhaps polar stratospheric clouds or hurricane-induced ocean mixing—to amplify early Palaeogene polar temperatures.
Abstract: The Palaeocene/Eocene thermal maximum, ~55 million years ago, was a brief period of widespread, extreme climatic warming1, 2, 3, that was associated with massive atmospheric greenhouse gas input4. Although aspects of the resulting environmental changes are well documented at low latitudes, no data were available to quantify simultaneous changes in the Arctic region. Here we identify the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence obtained during the Arctic Coring Expedition5. We show that sea surface temperatures near the North Pole increased from ~18 °C to over 23 °C during this event. Such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. At the same time, sea level rose while anoxic and euxinic conditions developed in the ocean's bottom waters and photic zone, respectively. Increasing temperature and sea level match expectations based on palaeoclimate model simulations6, but the absolute polar temperatures that we derive before, during and after the event are more than 10 °C warmer than those model-predicted. This suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms—perhaps polar stratospheric clouds7 or hurricane-induced ocean mixing8—to amplify early Palaeogene polar temperatures.

652 citations

Journal ArticleDOI
TL;DR: A somatic mutation and a gene variation in human lung cancer cells that change glycine to cysteine in the DGR domain are found, introducing local conformational changes that reduce Keap1's affinity for Nrf2.

651 citations

Journal ArticleDOI
TL;DR: The profile of choroidal thickness depends on its location, and RE, axial length, and especially age are critical for evaluation of chiroidal thickness.
Abstract: Purpose. To study posterior choroidal thickness and its profile based on location in healthy Japanese subjects and the correlation with axial length, refractive error (RE), and age. Methods. Eighty-six eyes of 43 healthy volunteers with no ophthalmic or systemic symptoms were examined with prototype high-penetration optical coherence tomography using a 1060-nm light source. Eyes with high myopia (exceeding -6 D) or with retinal/choroidal disease were excluded. The spherical equivalent RE was measured by autorefractometry, and the axial length was measured by partial coherence inferometry. Results. Mean choroidal thicknesses were 354 +/- 111 mum at the fovea, 364 +/- 86 mum superiorly, 345 +/- 108 mum inferiorly, 227 +/- 532 mum nasally, and 337 +/- 102 mum temporally. Subfoveal choroidal thickness was significantly greater than nasal (P < 0.01) and temporal (P < 0.05) choroidal thickness; however, there was no significant difference compared with superior (P = 0.20) and inferior (P = 0.17) choroidal thickness. The temporal choroid was significantly (P < 0.01) thicker than the nasal choroid, and the inferior choroid was significantly (P < 0.01) thinner than the superior choroid. There was a significant negative correlation between foveal choroidal thickness and axial length (P < 0.05) but a borderline correlation with the RE (P = 0.086) and age (P = 0.07). Age was the factor that was most associated with the choroidal thickness (F = 20.86; P < 0.001), followed by RE (F = 5.37; P < 0.05); axial length was not a significant factor (F = 1.47; P = 0.22) by stepwise analysis. Conclusions. The profile of choroidal thickness depends on its location. RE, axial length, and especially age are critical for evaluation of choroidal thickness.

650 citations

Journal ArticleDOI
TL;DR: Here it is explained why In-containing (Al,In,Ga)N bulk films exhibit a defect-insensitive emission probability, and it is concluded that localizing valence states associated with atomic condensates of In–N preferentially capture holes, which have a positive charge similar to positrons.
Abstract: Group-III-nitride semiconductors have shown enormous potential as light sources for full-colour displays, optical storage and solid-state lighting. Remarkably, InGaN blue- and green-light-emitting diodes (LEDs) emit brilliant light although the threading dislocation density generated due to lattice mismatch is six orders of magnitude higher than that in conventional LEDs. Here we explain why In-containing (Al,In,Ga)N bulk films exhibit a defect-insensitive emission probability. From the extremely short positron diffusion lengths (<4 nm) and short radiative lifetimes of excitonic emissions, we conclude that localizing valence states associated with atomic condensates of In-N preferentially capture holes, which have a positive charge similar to positrons. The holes form localized excitons to emit the light, although some of the excitons recombine at non-radiative centres. The enterprising use of atomically inhomogeneous crystals is proposed for future innovation in light emitters even when using defective crystals.

645 citations

Journal ArticleDOI
TL;DR: Induction of nrf2-dependent genes involved in the recognition and repair/removal of damaged proteins expands the role of this pathway beyond primary control of electrophilic and oxidative stresses into secondary protective actions that enhance cell survival.

640 citations


Authors

Showing all 36572 results

NameH-indexPapersCitations
Aaron R. Folsom1811118134044
Kazuo Shinozaki178668128279
Hyun-Chul Kim1764076183227
Masayuki Yamamoto1711576123028
Hua Zhang1631503116769
Lewis L. Lanier15955486677
David Cella1561258106402
Takashi Taniguchi1522141110658
Yoshio Bando147123480883
Kazuhiko Hara1411956107697
Janet Rossant13841671913
Christoph Paus1371585100801
Kohei Miyazono13551568706
Craig Blocker134137994195
Fumihiko Ukegawa133149294465
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023104
2022323
20214,079
20203,887
20193,515
20183,388