A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor
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TLDR
This work has defined the 13 bp palindrome GGTCACAGTGACC as a minimal functional estrogen responsive element (ERE), which binds estrogen receptor preferentially in vitro and point mutations within the ERE decrease its affinity for the estrogen receptor and result in a complete loss of estrogen inducibility.Abstract:
Sequences located upstream of the transcription initiation site of the Xenopus vitellogenin A2 (vit A2) gene contain a hormone dependent enhancer that confers estrogen control to the heterologous thymidine kinase (tk) promoter. As a minimal functional estrogen responsive element (ERE), we have defined the 13 bp palindrome GGTCACAGTGACC. This ERE binds estrogen receptor preferentially in vitro. Although the ERE shares some structural features with the glucocorticoid responsive element (GRE) it is distinct from this element since it neither binds glucocorticoid receptor in vitro nor does it confer glucocorticoid inducibility to a fusion gene. Point mutations within the ERE decrease its affinity for the estrogen receptor and result in a complete loss of estrogen inducibility.read more
Citations
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Human Estrogen Receptor Bound to an Estrogen Response Element
TL;DR: In this article, the authors used gel mobility shift assays to examine changes in DNA bending induced by binding of human estrogen receptor (hER) to a series of estrogen response element (ERE) containing DNA fragments.
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Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.
TL;DR: The similarities in vitamin B6 effects on transcription mediated through different promoters, the mouse mammary tumor virus and vitellogenin promoters, suggest that this vitamin may modulate the expression of a diverse array of hormonally responsive genes.
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Context-dependent transcription: all politics is local.
TL;DR: The local bending of the double helix, typically mediated by architectural transcription factors, is often critical for stabilizing enhanceosomes formed from trans-acting proteins separated over small and large distances.
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The p53-Estrogen Receptor Loop in Cancer
TL;DR: This review will summarize the current body of knowledge on p53, ERα and ERβ in cancer and discuss the relationship between p53 and ERs at both the molecular and clinical levels.
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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy
Peiye Song,Yanru Li,Yuan Dong,Yingying Liang,Huinan Qu,Da Qi,Yan Lu,Xiangshu Jin,Yantong Guo,Yiyang Jia,Xinqi Wang,Wenhong Xu,Chengshi Quan +12 more
TL;DR: This is the first study to demonstrate that the inhibitory effect of ERβ on the migration and invasion of breast cancer cells was mediated by CLDN6, which induced the beclin1-dependent autophagic cascade.
References
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Book
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