A novel nutrient sensing mechanism underlies substrate-induced regulation of monocarboxylate transporter-1.
Alip Borthakur,Shubha Priyamvada,Anoop Kumar,Arivarasu A. Natarajan,Ravinder K. Gill,Waddah A. Alrefai,Pradeep K. Dudeja +6 more
TLDR
Evidence is provided for substrate-induced enhancement of MCT1 surface expression and function via a novel nutrient sensing mechanism involving GPR109A as a SCFA sensor.Abstract:
Monocarboxylate transporter isoform-1 (MCT1) plays an important role in the absorption of short-chain fatty acids (SCFAs) in the colon. Butyrate, a major SCFA, serves as the primary energy source f...read more
Citations
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Journal ArticleDOI
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.
Daniela Parada Venegas,Marjorie De la Fuente,Glauben Landskron,María-Julieta González,Rodrigo Quera,Gerard Dijkstra,Hermie J. M. Harmsen,Klaas Nico Faber,Marcela A. Hermoso +8 more
TL;DR: An overview of microbial SCFAs production and their effects on the intestinal mucosa with specific emphasis on their relevance for Inflammatory Bowel Diseases is presented and the therapeutic potential ofSCFAs for IBD is discussed.
Book ChapterDOI
The role of short-chain fatty acids in health and disease.
Jian Tan,Craig R. M. McKenzie,Maria Potamitis,Alison N. Thorburn,Charles R. Mackay,Laurence Macia +5 more
TL;DR: The role of SCFAs as a major player in maintenance of gut and immune homeostasis is highlighted, and their levels are regulated by diet are provided a new basis to explain the increased prevalence of inflammatory disease in Westernized countries.
Journal ArticleDOI
Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders
TL;DR: Butyrate, propionate and acetate are short chain fatty acids, important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis, but they may also regulate immune responses and the composition of the intestinal microbiota.
Journal ArticleDOI
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism.
Jin He,Peiwen Zhang,Linyuan Shen,Lili Niu,Ya Tan,Lei Chen,Ye Zhao,Lin Bai,Hao Xiaoxia,Xuewei Li,Shunhua Zhang,Li Zhu +11 more
TL;DR: This review summarizes the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism and discusses the role of GPRCs and HDACs in these pathways.
Journal ArticleDOI
Towards microbial fermentation metabolites as markers for health benefits of prebiotics
Kristin Verbeke,Alan R. Boobis,Alessandro Chiodini,Christine A. Edwards,Anne Franck,Michiel Kleerebezem,Arjen Nauta,Jeroen Raes,Eric A.F. van Tol,Kieran Tuohy +9 more
TL;DR: There is insufficient evidence to use changes in faecal bacterial metabolite concentrations as markers of prebiotic effectiveness, and adequate tools for data integration and interpretation are currently lacking.
References
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Journal ArticleDOI
Review article: the role of butyrate on colonic function
Henrike M. Hamer,Daisy Jonkers,Koen Venema,Steven Vanhoutvin,Freddy J. Troost,Robert Brummer +5 more
TL;DR: Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis, and is a main end‐product of intestinal microbial fermentation of mainly dietary fibre.
Journal ArticleDOI
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Andrew J. Brown,Susan M. Goldsworthy,Ashley A. Barnes,Michelle M. Eilert,Lili Tcheang,Dion A. Daniels,Alison I. Muir,Mark J. Wigglesworth,Ian Kinghorn,Neil J. Fraser,Nicholas B. Pike,Jay C. Strum,Klaudia Steplewski,Paul R. Murdock,Julie C. Holder,Fiona H. Marshall,Philip G. Szekeres,Shelagh Wilson,Diane M. Ignar,Steve M. Foord,Alan Wise,Simon J. Dowell +21 more
TL;DR: GPR41 was expressed primarily in adipose tissue, whereas the highest levels of GPR43 were found in immune cells, and was activated by similar ligands but with differing specificity for carbon chain length, with pentanoate being the most potent agonist.
Journal ArticleDOI
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul,Cecile Loison,Sofie Struyf,Jean-Yves Springael,Vincent Lannoy,Marie-Eve Decobecq,Stéphane Brézillon,Vincent Dupriez,Gilbert Vassart,Jozef Van Damme,Marc Parmentier,Michel Detheux +11 more
TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
Journal ArticleDOI
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Roberto Berni Canani,Margherita Di Costanzo,Ludovica Leone,Monica Pedata,Rosaria Meli,Antonio Calignano +5 more
TL;DR: A wide spectrum of positive effects exerted by butyrate is suggested, with a high potential for a therapeutic use in human medicine, at the extraintestinal and intestinal level.
Journal ArticleDOI
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
Muthusamy Thangaraju,Gail Cresci,Kebin Liu,Sudha Ananth,Jaya P. Gnana-Prakasam,Darren D. Browning,John D. Mellinger,Sylvia B. Smith,Gregory J. Digby,Nevin A. Lambert,Puttur D. Prasad,Vadivel Ganapathy +11 more
TL;DR: It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses nuclear factor-kappaB activation in normal and cancer colon cell lines as well as in normal mouse colon.
Related Papers (5)
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Andrew J. Brown,Susan M. Goldsworthy,Ashley A. Barnes,Michelle M. Eilert,Lili Tcheang,Dion A. Daniels,Alison I. Muir,Mark J. Wigglesworth,Ian Kinghorn,Neil J. Fraser,Nicholas B. Pike,Jay C. Strum,Klaudia Steplewski,Paul R. Murdock,Julie C. Holder,Fiona H. Marshall,Philip G. Szekeres,Shelagh Wilson,Diane M. Ignar,Steve M. Foord,Alan Wise,Simon J. Dowell +21 more