A place for precision medicine in bladder cancer: targeting the FGFRs
TLDR
Current understanding of the molecular alterations affecting these receptors in bladder tumors, preclinical studies validating them as therapeutic targets, available FGFR-targeted agents and results from early clinical trials in bladder cancer patients are summarized.Abstract:
Bladder tumors show diverse molecular features and clinical outcome. Muscle-invasive bladder cancer has poor prognosis and novel approaches to systemic therapy are urgently required. Non-muscle-invasive bladder cancer has good prognosis, but high recurrence rate and the requirement for life-long disease monitoring places a major burden on patients and healthcare providers. Studies of tumor tissues from both disease groups have identified frequent alterations of FGFRs, including mutations of FGFR3 and dysregulated expression of FGFR1 and FGFR3 that suggest that these may be valid therapeutic targets. We summarize current understanding of the molecular alterations affecting these receptors in bladder tumors, preclinical studies validating them as therapeutic targets, available FGFR-targeted agents and results from early clinical trials in bladder cancer patients.read more
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Journal ArticleDOI
Advances in bladder cancer biology and therapy
TL;DR: Recent developments in the molecular and translational aspects of bladder cancer biology are examined and their current or potential future clinical applications in the management of bladdercancer are discussed.
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Fibroblast growth factor receptors as treatment targets in clinical oncology
TL;DR: The clinical experience with FGFR inhibitors to date is described, and key aspects that might lead to improved response rates and/or the avoidance of acquired resistance are highlighted, including the selection of patients who are most likely to benefit from treatment, and the use ofFGFR inhibitors in combination regimens with other agents.
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Targeted therapies for advanced bladder cancer: new strategies with FGFR inhibitors:
Chiara Casadei,Nazli Dizman,Giuseppe Schepisi,Maria Concetta Cursano,Umberto Basso,Daniele Santini,Sumanta K. Pal,Ugo De Giorgi +7 more
TL;DR: An overview of the results of recent clinical trials on FGFR tyrosine kinase inhibitors currently in clinical development for the treatment of UC, and future therapeutic options of combination regimens with immune-checkpoint inhibitors as strategies for improving the antitumor effects of this class of drug.
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Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression.
Cornelia Braicu,Rares Buiga,Roxana Cojocneanu,Mihail Buse,Lajos Raduly,Laura Pop,Sergiu Chira,Liviuta Budisan,Ancuta Jurj,Cristina Ciocan,Lorand Magdo,Alexandru Irimie,Florentin Dobrota,Bogdan Petrut,Ioana Berindan-Neagoe +14 more
TL;DR: Altered miRNAs patterns are interrelated to bladder tumorigenesis, allowing them to be used for the development of novel diagnostic and prognostic biomarkers, and can assist for better patient diagnosis.
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Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
Agnieszka Latosinska,Marika Mokou,Marika Mokou,Manousos Makridakis,William Mullen,Jerome Zoidakis,Vasiliki Lygirou,Maria Frantzi,Ioannis Katafigiotis,Konstantinos Stravodimos,Marie C. Hupe,Maciej Dobrzyński,Walter Kolch,Axel S. Merseburger,Harald Mischak,Maria G. Roubelakis,Maria G. Roubelakis,Antonia Vlahou +17 more
TL;DR: This study characterizes proteomic changes underlying bladder cancer invasion aiming for the better understanding of disease pathophysiology and identification of drug targets and highlights EIF3D as a potential therapeutic target.
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Comprehensive molecular characterization of urothelial bladder carcinoma
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TL;DR: Ch Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities.
Journal ArticleDOI
Neoadjuvant Chemotherapy plus Cystectomy Compared with Cystectomy Alone for Locally Advanced Bladder Cancer
H. Barton Grossman,Ronald B. Natale,Catherine M. Tangen,V. O. Speights,Nicholas J. Vogelzang,Donald L. Trump,Ralph W deVere White,Michael F. Sarosdy,David P. Wood,Derek Raghavan,E. David Crawford +10 more
TL;DR: Using neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin followed by radical cystectomy increases the likelihood of eliminating residual cancer in the Cystectomy specimen and is associated with improved survival among patients with locally advanced bladder cancer.
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