Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
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TLDR
A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.Abstract:
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.read more
Citations
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Journal ArticleDOI
Ghrelin Receptors in Non-Mammalian Vertebrates
TL;DR: In this review, current information related to the ghrelin receptor in non-mammalian vertebrates is summarized.
Journal ArticleDOI
Sequence, genomic organization and expression of two channel catfish, Ictalurus punctatus, ghrelin receptors
TL;DR: This is the first characterization of GHS-R2a and suggests regulatory and functional differences between the two catfish receptors.
Journal ArticleDOI
Ghrelin: New Insights into Female Reproductive System–Associated Disorders and Pregnancy
George Angelidis,Konstantinos Dafopoulos,Christina I. Messini,Varvara Valotassiou,Panagiotis Georgoulias,Ioannis E. Messinis +5 more
TL;DR: The endocrine network, which integrates energy balance and fertility, might involve ghrelin, which has been shown to influence the reproductive system by regulating hormone secretion from the brain and by acting directly on the gonads to affect tissue development and steroidogenesis.
Journal ArticleDOI
Effect of obesity on linear growth.
TL;DR: The elements of neuroendocrine systems contributing to the integration of metabolic controls involved in growth regulation in the obese child are reviewed with particular emphasis on growth hormone, ghrelin, insulin-like growth factors and insulin.
Journal ArticleDOI
Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.
TL;DR: It is speculated that aging is associated with deficient endogenous ghrelin signaling that can be rescued by intervention with GHS‐R1a agonists to improve quality of life and maintain independence.
References
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Journal ArticleDOI
Effects of Human Growth Hormone in Men over 60 Years Old
Daniel Rudman,Axel G. Feller,Hoskote S. Nagraj,Gregory A. Gergans,Pardee Y. Lalitha,Allen Fred Goldberg,Robert A. Schlenker,Lester Cohn,Inge W. Rudman,Dale E. Mattson +9 more
TL;DR: Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.
Journal ArticleDOI
On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
TL;DR: [His1,Lys6] GHRP may be a valuable peptide for investigating the function of the pituitary somatotrophs and has the potential for increasing BW gain of a variety of normal animals by inducing GH release via a direct pituitsary site of action.
Journal ArticleDOI
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering
TL;DR: The pSG5 vector as mentioned in this paper was constructed by combining the eukaryotic expression vector, pKCR2, and the high copy plasmid vector Bluescribe Ml3+ (Stratagene).
Journal ArticleDOI
Expression cloning of a human B1 bradykinin receptor.
John G. Menke,Joseph A. Borkowski,Kathleen K. Bierilo,Tanya MacNeil,Amanda W. Derrick,K.A. Schneck,Richard W. Ransom,Catherine D. Strader,David L. Linemeyer,J.F. Hess +9 more
TL;DR: The availability of both the cloned human B1 and B2 bradykinin receptors should allow the elucidation of the relative contributions of these two receptor subtypes in acute and chronic inflammatory processes.
Journal ArticleDOI
A nonpeptidyl growth hormone secretagogue
Roy G. Smith,Kang Cheng,William R. Schoen,Sheng-Shung Pong,Gerard J. Hickey,Tom Jacks,B. Butler,Wanda W.-S. Chan,L.-Y. Chaung,F Judith +9 more
TL;DR: The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Tr phe-Phe-Lys-NH2 (GHRP-6).