Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
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TLDR
A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.Abstract:
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.read more
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The somatotropic axis in critical illness: effect of continuous growth hormone (GH)-releasing hormone and GH-releasing peptide-2 infusion.
Greet Van den Berghe,Francis de Zegher,Johannes D. Veldhuis,Pieter Wouters,Mariet Awouters,Werner Verbruggen,Miet Schetz,Charles Verwaest,Peter Lauwers,Roger Bouillon,Cyril Y. Bowers +10 more
TL;DR: In critically ill adults, low serum IGF-I levels were positively correlated with diminished pulsatile and increased basal GH secretion, and both basal and pulsatile GH secretion were moderately increased by continuous infusion of GHRH, substantially increased by GHRP-2, and strikingly increased byGHRH plus GHRp-2.
Journal ArticleDOI
Presence of ghrelin in normal and adenomatous human pituitary.
TL;DR: It is suggested that in addition to the probable hypothalamic effects of ghrelin, the peptide is synthesized locally within the pituitary gland, where it may influence the release of GH in an autocrine or paracrine manner.
Journal ArticleDOI
Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature.
Hai-Jun Wang,Frank Geller,Astrid Dempfle,Nadine Schäuble,Susann Friedel,Peter Lichtner,Francisco Fontenla-Horro,Stefan A. Wudy,Sandra Hagemann,Ludwig Gortner,Klaus Huse,Helmut Remschmidt,Thomas Bettecken,Thomas Meitinger,Helmut Schäfer,Johannes Hebebrand,Anke Hinney +16 more
TL;DR: In conclusion, there is no conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in the study groups.
Journal ArticleDOI
Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone‐secretagogues
Greet Van den Berghe,Francis de Zegher,Johannes D. Veldhuis,Pieter Wouters,Stefaan Gouwy,Willem Stockman,Frank Weekers,Miet Schetz,Peter Lauwers,Roger Bouillon,Cyril Y. Bowers +10 more
TL;DR: The dynamic characteristics of spontaneous nightly TSH and PRL secretion during prolonged critical illness are reported, together with the concomitant effects exerted by the administration of GH‐secretagogues, GH‐releasing hormone (GHRH) and GH-releasing peptide‐2 (G HRP‐2) in particular, on night‐time TSHandPRL secretion.
Journal ArticleDOI
The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior.
Mark Fry,Alastair V. Ferguson +1 more
TL;DR: This review focuses primarily on the roles played by the sensory CVOs in fluid balance and energy metabolism.
References
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Journal ArticleDOI
Effects of Human Growth Hormone in Men over 60 Years Old
Daniel Rudman,Axel G. Feller,Hoskote S. Nagraj,Gregory A. Gergans,Pardee Y. Lalitha,Allen Fred Goldberg,Robert A. Schlenker,Lester Cohn,Inge W. Rudman,Dale E. Mattson +9 more
TL;DR: Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.
Journal ArticleDOI
On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
TL;DR: [His1,Lys6] GHRP may be a valuable peptide for investigating the function of the pituitary somatotrophs and has the potential for increasing BW gain of a variety of normal animals by inducing GH release via a direct pituitsary site of action.
Journal ArticleDOI
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering
TL;DR: The pSG5 vector as mentioned in this paper was constructed by combining the eukaryotic expression vector, pKCR2, and the high copy plasmid vector Bluescribe Ml3+ (Stratagene).
Journal ArticleDOI
Expression cloning of a human B1 bradykinin receptor.
John G. Menke,Joseph A. Borkowski,Kathleen K. Bierilo,Tanya MacNeil,Amanda W. Derrick,K.A. Schneck,Richard W. Ransom,Catherine D. Strader,David L. Linemeyer,J.F. Hess +9 more
TL;DR: The availability of both the cloned human B1 and B2 bradykinin receptors should allow the elucidation of the relative contributions of these two receptor subtypes in acute and chronic inflammatory processes.
Journal ArticleDOI
A nonpeptidyl growth hormone secretagogue
Roy G. Smith,Kang Cheng,William R. Schoen,Sheng-Shung Pong,Gerard J. Hickey,Tom Jacks,B. Butler,Wanda W.-S. Chan,L.-Y. Chaung,F Judith +9 more
TL;DR: The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Tr phe-Phe-Lys-NH2 (GHRP-6).