Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
Reads0
Chats0
TLDR
A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.Abstract:
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.read more
Citations
More filters
Journal ArticleDOI
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers.
TL;DR: Anamorelin increases GH, IGF-1, IGFBP-3 and body weight with good tolerability and selectivity, without affecting other anterior pituitary axes or fasting glucose levels.
Journal ArticleDOI
Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding
TL;DR: Ghrelin, an n-octanoylated 28-amino acid brain-gut peptide, was first isolated from extracts of porcine stomach and was used to stimulate feeding and growth hormone secretion as mentioned in this paper.
Journal ArticleDOI
Immunohistochemical evidence for an endocrine/paracrine role for ghrelin in the reproductive tissues of sheep.
David W. Miller,David W. Miller,David W. Miller,Joanne L. Harrison,Joanne L. Harrison,Yvonne A. Brown,Una Doyle,Alanna Lindsay,Clare Lesley Adam,Richard G. Lea +9 more
TL;DR: In this paper, the authors used immunohistochemistry to investigate the presence of ghrelin and growth hormone secretagogue receptors (GHSR-1a) in sheep reproductive tissues.
Journal ArticleDOI
Effects of Hormones on Sleep
Axel Steiger,Irina A. Antonijevic,S. Bohlhalter,Ralf-Michael Frieboes,Elisabeth Friess,Harald Murck +5 more
TL;DR: Administration of hormones to humans and animals results in specific effects on the sleep electroencephalogram (EEG) and nocturnal hormone secretion, which can be explained by γ-aminobutyric acidA receptor modulation.
Journal ArticleDOI
Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues.
TL;DR: A fragment of the rat GH-releasing peptide (GHRP) receptor homologue was cloned and the tissue distribution of GHRP receptor mRNA in rats revealed that G HRP receptor mRNAs were localized predominantly in the arcuate nucleus and ventromedial hypothalamus.
References
More filters
Journal ArticleDOI
Effects of Human Growth Hormone in Men over 60 Years Old
Daniel Rudman,Axel G. Feller,Hoskote S. Nagraj,Gregory A. Gergans,Pardee Y. Lalitha,Allen Fred Goldberg,Robert A. Schlenker,Lester Cohn,Inge W. Rudman,Dale E. Mattson +9 more
TL;DR: Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.
Journal ArticleDOI
On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
TL;DR: [His1,Lys6] GHRP may be a valuable peptide for investigating the function of the pituitary somatotrophs and has the potential for increasing BW gain of a variety of normal animals by inducing GH release via a direct pituitsary site of action.
Journal ArticleDOI
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering
TL;DR: The pSG5 vector as mentioned in this paper was constructed by combining the eukaryotic expression vector, pKCR2, and the high copy plasmid vector Bluescribe Ml3+ (Stratagene).
Journal ArticleDOI
Expression cloning of a human B1 bradykinin receptor.
John G. Menke,Joseph A. Borkowski,Kathleen K. Bierilo,Tanya MacNeil,Amanda W. Derrick,K.A. Schneck,Richard W. Ransom,Catherine D. Strader,David L. Linemeyer,J.F. Hess +9 more
TL;DR: The availability of both the cloned human B1 and B2 bradykinin receptors should allow the elucidation of the relative contributions of these two receptor subtypes in acute and chronic inflammatory processes.
Journal ArticleDOI
A nonpeptidyl growth hormone secretagogue
Roy G. Smith,Kang Cheng,William R. Schoen,Sheng-Shung Pong,Gerard J. Hickey,Tom Jacks,B. Butler,Wanda W.-S. Chan,L.-Y. Chaung,F Judith +9 more
TL;DR: The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Tr phe-Phe-Lys-NH2 (GHRP-6).