Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Book ChapterDOI
Schwann Cells in Nerve Repair and Regeneration
TL;DR: In this paper , it has been shown that after peripheral nerve injury, both Schwann cells and PNS neurons reprogram to new phenotypes that promote axonal regeneration, and the regeneration phenotype fades with time after injury, and in aged animals the activation of the repair phenotype is subdued.
Journal ArticleDOI
Restoration of the Topological Organization of the Trigeminal System Following Trigeminal Nerve Root Injury in the Lamprey
TL;DR: Following trigeminal nerve root injury, several mechanisms, including axonal guidance cues, probably contribute to the substantial restoration of the topological organization of the lamprey trigeminals system.
Book ChapterDOI
New Strategies in Composite Tissue Allotransplantation
TL;DR: This chapter introduces a brief historical perspective as well as a description of the current state of play within the discipline, examines emerging challenges and then focuses on novel research avenues and clinical perspectives for the future.
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Freeze-dried platelet-rich plasma promotes trigeminal neuropathic pain relief in a rat model
TL;DR: FD-PRP promotes nerve regeneration in axonotmesis, which was characterized by a decrease in face grooming frequency on day 7 and an increase in the number of lymphocytes, macrophages and Schwann cells on day 21.
Journal ArticleDOI
Systematic Comparison of Commercial Hydrogels Revealed That a Synergy of Laminin and Strain-Stiffening Promotes Directed Migration of Neural Cells
Flavia Millesi,Sascha Mero,Lorenz Semmler,A. Yazdi rad,Sarah Stadlmayr,A Borger,P Supper,M. Haertinger,Leon Ploszczanski,Ursula Windberger,T. Weiss,Aida Naghilou,Christine Radtke +12 more
TL;DR: In this paper , the authors compared commercially available hydrogels and found that Laminin was the driver behind cell elongation and in combination with a porous, fibrous, and strain-stiffening matrix structure responsible for oriented cell motility.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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