Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Current Approaches to Peripheral Nervous Tissue Regeneration – Mimicking Nature. A review
TL;DR: The anatomy of peripheral nerve tissue is described and current understanding of biochemical processes involved in its development as well as in the body’s response to its damage are dealt with to create an ideal approach to this field of tissue engineering.
Journal ArticleDOI
Discussion: Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury.
Ian C. Sando,Paul S. Cederna +1 more
TL;DR: There remains a need for new strategies to optimize axonal regeneration and maintain the health and viability of target tissues following peripheral nerve injury.
Journal Article
Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerve repair through a macrophage-dependent mechanism.
Yongbin Ma,Chuan Wei,Xin Qi,Yanan Pu,Liyang Dong,Lei Xu,Sha Zhou,Jifeng Zhu,Xiaojun Chen,Xuefeng Wang,Chuan Su +10 more
TL;DR: In this article, the authors demonstrated that schistosome-derived SJMHE1 promoted peripheral myelin growth and functional regeneration via a macrophage-dependent mechanism and simultaneously increased the induction of M2 macrophages.
Journal ArticleDOI
Neurotoxic effect of aspartame on the sciatic nerve of adult male albino rat and the possibility of spontaneous recovery: light and electron microscopic study
Enas Anwar Bekheet,Hagar Y. Rady +1 more
TL;DR: The results supported the neurotoxic effect of aspartame on rats’ sciatic nerves when consumed regularly for a long period and proved that the spontaneous recovery wasn’t complete.
Book ChapterDOI
Application of Schwann Cells in Neural Tissue Engineering
Li Yao,Priyanka Priyadarshani +1 more
TL;DR: In this chapter, the critical role of Schwann cell in peripheral and spinal cord injuries is reviewed and transplantation can significantly enhance regeneration post-neural tissue injury.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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