Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Screening of NogoA/NTR-related differential genes in rat sciatic nerve injury signal pathway.
TL;DR: MAPK, endophagocytic, apoptotic, neurotrophic factor and inflammatory mediators of ductal mediators may be involved in the sciatic nerve injury in rats.
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Revisiting the Role of Biologically Active Natural and Synthetic Compounds as an Intervention to Treat Injured Nerves.
Natália Melo Souza,Mateus Figueiredo Gonçalves,Luiz Fernando Romanholo Ferreira,Muhammad Bilal,Hafiz M.N. Iqbal,Renato N. Soriano +5 more
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Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve.
TL;DR: It is suggested that vitamin D3 is an effective agent in prevention of ischemic peripheral nerve insults and beneficial effect on regeneration after epineurial devascularization.
Journal ArticleDOI
Dual-bionic regenerative microenvironment for peripheral nerve repair
Yanjun Guan,Zhiqi Ren,Boyao Yang,Wenjing Xu,Wen Ni Wu,Tieyuan Zhang,Dongdong Li,Xiangling Li,Shengfeng Chen,Songlin He,Chaochao Li,Fan Xue Meng,Tong Wu,Jun Bai,Jian Zhang,Xiuzhi Liu,Jiang Peng,Yu Wang +17 more
TL;DR: In this article , a dual-bionic nerve regeneration material was successfully fabricated using polycaprolactone/silk fibroin (PCL/SF)-aligned electrospun material with extracellular matrix (ECM) derived from human umbilical cord mesenchymal stem cells.
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Time-course gait pattern analysis in a rat model of foot drop induced by ventral root avulsion injury
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References
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Journal ArticleDOI
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Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
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Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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