Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
More filters
Journal ArticleDOI
Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?
Manal Hassanien,Abdelraheem Elawamy,Emad Zarief Kamel,Walaa A Khalifa,Ghada Mohamed Abolfadl,Al Shimaa Ismael Roushdy,Randa A. El Zohne,Yasmine S. Makarem +7 more
TL;DR: Perineural PRP injection is an effective therapy for alleviation of diabetic neuropathy pain and numbness and enhancement of peripheral nerve function.
Journal ArticleDOI
Neural tissue engineering: From bioactive scaffolds and in situ monitoring to regeneration
TL;DR: In this paper , the authors discuss the recent progress on the design and construction of tissue engineered nerve guidance conduits (NGCs) in combination with biological effectors and cellular components for nerve repair and explore the prospects of multifunctional platforms to promote the repair of peripheral nerve injury.
Journal ArticleDOI
Modulation of BDNF-TRKB Interactions on Schwann Cell-induced Oral Squamous Cell Carcinoma Dispersion In Vitro.
Liliana Ein,Christine Mei,Olena Bracho,Esperanza Bas,Paula V. Monje,Donald T. Weed,Zoukaa Sargi,Giovana R. Thomas,Christine T. Dinh +8 more
TL;DR: This pilot study shows that BDNF–TRKB signaling may have a role in regulating interactions between SC and oral cancer cells that affect cell migration, intercalation, and cancer cell dispersion.
Journal ArticleDOI
Mitochondrial Damage-Associated Molecular Patterns of Injured Axons Induce Outgrowth of Schwann Cell Processes
Andrea Korimová,Ilona Klusáková,Ivana Hradilová-Svíženská,Marcela Hortová Kohoutková,Marek Joukal,Petr Dubový +5 more
TL;DR: Results present the first evidence that potential mtDAMPs may play a key role in the induction of Schwann cell processes, mediated via FPR2 and TLR9 that are canonical receptors for formylated peptides and mtDNA.
Journal ArticleDOI
Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages.
TL;DR: Findings confirm a difference in sciatic nerve gene expression between adult and young rats, suggesting that, in peripheral nerves, cells and the microenvironment change with age, thus influencing the function and repair of peripheral nerves.
References
More filters
Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
Related Papers (5)
The repair Schwann cell and its function in regenerating nerves
Kristjan R. Jessen,Rhona Mirsky +1 more