Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Self-Adaptive All-In-One Delivery Chip for Rapid Skin Nerves Regeneration by Endogenous Mesenchymal Stem Cells
Li-Hua Peng,Li-Hua Peng,Xue-Han Xu,Yan-Fen Huang,Xiaoli Zhao,Bo Zhao,Shengying Cai,Ming‐Jun Xie,Mao-Ze Wang,Tie-Jun Yuan,Yong He,Zhen Xu,Jian-Qing Gao,Chao Gao +13 more
TL;DR: G:P:Al‐Chip is shown to enhance nerve regeneration with excitation functions within 23 days and organizes recruitment and neuronal regeneration cues along with bioelectrical signal in one degradable chip for accelerated skin nerve regeneration.
Journal ArticleDOI
Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications.
Yong Xu,Michelle Patino Gaillez,Rebecca Rothe,Rebecca Rothe,Sandra Hauser,Dagmar Voigt,Jens Pietzsch,Jens Pietzsch,Yixin Zhang +8 more
TL;DR: An overview of the design, synthesis, and engineering of dynamic conductive hydrogels is presented in this paper, focusing on the different dynamic crosslinking mechanisms of DCHs and their biomedical applications.
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Erection rehabilitation following prostatectomy--current strategies and future directions
TL;DR: To further improve outcomes, erection rehabilitation strategies are being investigated, which emphasize early treatment regimens with the aim of preventing adverse remodelling after surgery and preserving erectile function.
Journal ArticleDOI
Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation
Don-Ching Lee,Jong-Hang Chen,Tai-Yu Hsu,Li-Hsun Chang,Hsu Chang,Ya-Hui Chi,Ing-Ming Chiu,Ing-Ming Chiu +7 more
TL;DR: It is suggested that IL12p80 can trigger Schwann cell differentiation of mouse NSCs through Stat3 phosphorylation and enhance the functional recovery and the diameter of regenerated nerves in a mouse sciatic nerve injury model.
Journal ArticleDOI
Enhanced performance of chitosan/keratin membranes with potential application in peripheral nerve repair
Cristiana R. Carvalho,João B. Costa,Lígia Costa,Joana Silva-Correia,Zi Kuang Moay,Kee Woei Ng,Rui L. Reis,Joaquim M. Oliveira +7 more
TL;DR: The obtained results indicate the higher potential of CHT/keratin membranes for guided tissue regeneration applications in the field of PNR.
References
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Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
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Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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