Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Journal ArticleDOI
Hybrid material mimics a hypoxic environment to promote regeneration of peripheral nerves.
Qi Quan,Lei Hong,Yu Wang,Rui Li,Xin Yin,Xiao-Qing Cheng,Guang-Bo Liu,Tang He,Haoye Meng,Shuyun Liu,Quanyi Guo,Bi-Qin Lai,Qing Zhao,Min Wei,Jiang Peng,Peifu Tang +15 more
TL;DR: In this paper, a functional material that mimics hypoxia during the early stages of nerve regeneration by deferoxamine was developed, and single-cell sequencing was performed to analyze the "bridge" structure between peripheral nerve defects.
Journal ArticleDOI
Material advancement in tissue-engineered nerve conduit
Journal ArticleDOI
CXCL1 and CXCL2 Inhibit the Axon Outgrowth in a Time- and Cell-Type-Dependent Manner in Adult Rat Dorsal Root Ganglia Neurons
Antonia Teona Deftu,Ruxandra Ciorescu,Roxana-Olimpia Gheorghe,Dan Mihailescu,Violeta Ristoiu +4 more
TL;DR: The results showed that both chemokines significantly inhibited the axon outgrowth, with large and medium NF200 (NeuroFilament 200) dorsal root ganglia neurons affected quicker, compared to small IB4 (Isolectin B4) (+) dorsal Root Ganglia neurons which were affected after longer exposure, suggesting that CXCR2 may represent a new therapeutic target for promoting the ax on growth after a peripheral nerve injury.
Journal ArticleDOI
A biodegradable block polyurethane nerve-guidance scaffold enhancing rapid vascularization and promoting reconstruction of transected sciatic nerve in Sprague-Dawley rats.
Yuqing Niu,Massimiliano Galluzzi +1 more
TL;DR: This study designed an amphiphilic alternating block polyurethane (abbreviated as PU) copolymer-based nerve guidance scaffold, which has good Schwann cell compatibility, and more importantly, a rapid vascularization of the scaffold in vivo, which enhances recovery and re-obtains nerve conduction function.
Journal ArticleDOI
The ATP-P2X7 Signaling Pathway Participates in the Regulation of Slit1 Expression in Satellite Glial Cells.
Quan-Peng Zhang,Jiu-Hong Zhao,Jiu-Hong Zhao,Jing Shen,Xianfang Zhang,Xianfang Zhang,Rui Ren,Rui Ren,Zhi-Jian Ma,Zhi-Jian Ma,Yuebin He,Qian Kang,Yanshan Wang,Xu Dong,Jin Sun,Zhuozhou Liu,Xi-Nan Yi,Xi-Nan Yi +17 more
TL;DR: Results indicate that the ATP-P2X7R pathway is involved in signal transduction from peripheral nerve injury to SGCs, leading to the upregulation of Slit1 expression.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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