Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
More filters
Journal ArticleDOI
An animal model induced by bilateral cavernous nerve crushing mimics post-radical prostatectomy erectile dysfunction in old rats.
TL;DR: Wang et al. as discussed by the authors evaluated bilateral CN crushing (BCNC) effects on erectile function besides penile corpus cavernosum pathology in young and old rats and verified whether the BCNC modeling in old rats is more suitable to mimic pRP-ED.
Journal ArticleDOI
Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization
TL;DR: In this paper , a thorough review of peripheral nerve anatomy, physiology, and the regenerative mechanisms that occur in response to injury is provided, followed by a discussion of currently available interventions for peripheral nerve injuries.
Journal ArticleDOI
Li–Mg–Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration
Yiting Sun,Hongjiang Zhang,Yu Zhang,Zheqi Liu,Dongming He,Wan-ting Xu,Siyi Li,Chenping Zhang,Zhen Zhang +8 more
TL;DR: In this paper , the inorganic lithium-magnesium-silicon (Li-Mg-Si, LMS) bioceramics containing scaffolds were fabricated and characterized, and the LMS-containing scaffolds had no cytotoxicity against rat Schwann cells (SCs), but promoted their migration and differentiation towards a remyelination state by upregulating the expression of neurotrophic factors in a β-catenin-dependent manner.
Book ChapterDOI
Liquid Metal as Electronic Medium to Recover Damaged Nerves’ Function
TL;DR: This chapter explains the basic principle to mold liquid metal as an unconventional medium to help the injured nerve recover the ability to conduct electroneurographic signals.
Journal ArticleDOI
Neuroprotective effects of celastrol on sciatic nerve transection model in male Wistar rats.
TL;DR: Celastrol is an herbal compound with neuroprotective properties as discussed by the authors , which has been shown to significantly accelerate nerve regeneration and improved sensorimotor functional recovery when compared with controls. But, the effects of celastrol are limited.
References
More filters
Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
Related Papers (5)
The repair Schwann cell and its function in regenerating nerves
Kristjan R. Jessen,Rhona Mirsky +1 more