Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Journal ArticleDOI
Coculture of Primary Motor Neurons and Schwann Cells as a Model for In Vitro Myelination.
Sujin Hyung,Sujin Hyung,Bo Yoon Lee,Bo Yoon Lee,Jong Chul Park,Jinseok Kim,Eun Mi Hur,Eun Mi Hur,Jun-Kyo Francis Suh +8 more
TL;DR: In this article, a simple and reproducible myelination culture system using mouse motor neurons (MNs) and Schwann cells (SCs) was introduced, where dissociated motor neurons are plated on a feeder layer of SCs, which interact with and wrap around the axons of MNs as they differentiate in culture.
Journal ArticleDOI
Roles of neural stem cells in the repair of peripheral nerve injury.
TL;DR: It can be concluded that neural stem cells promote the repair of peripheral nerve injury through a variety of ways.
Journal ArticleDOI
Functional nanomaterials in peripheral nerve regeneration: Scaffold design, chemical principles and microenvironmental remodeling
TL;DR: In this article, the authors systematically summarize the studies on the biomimetic scaffold design of functional nanomaterials, their basic topological, biochemical and physical properties, and nanotechnology-based restoration of a balanced nutritional microenvironment regarding four key neural regeneration factors, including immune response, intraneural vascularization, bioenergetic metabolism and bioelectrical conduction.
Journal ArticleDOI
Crosstalk between Bone and Nerves within Bone.
Qian Qian Wan,Wen Pin Qin,Yu Xuan Ma,Min Juan Shen,Jing Li,Zi Bin Zhang,Ji Hua Chen,Franklin R. Tay,Li Na Niu,Kai Jiao +9 more
TL;DR: In this article, the possible crosstalk between bone and intrabony peripheral nerves is comprehensively analyzed and harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves.
Journal ArticleDOI
Effect of exosomes from adipose-derived stem cells on the apoptosis of Schwann cells in peripheral nerve injury.
Caiyue Liu,Gang Yin,Yi-Dan Sun,Yaofa Lin,Zheng Xie,Arthur W. English,Li Qingfeng,Haodong Lin +7 more
TL;DR: Recovery after peripheral nerve injury (PNI) is often difficult, and there is no optimal treatment, so SC‐targeting treatments have gained importance.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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