Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Journal ArticleDOI
Growth Hormone Improves Nerve Regeneration, Muscle Re-innervation, and Functional Outcomes After Chronic Denervation Injury
Joseph Lopez,Amy Quan,Joshua Budihardjo,Sinan Xiang,Howard D. Wang,Koshy Kiron Koshy,Christopher R. Cashman,W. P. Andrew Lee,Ahmet Hoke,Sami H. Tuffaha,Gerald Brandacher +10 more
TL;DR: The hypothesis that GH-therapy enhances axonal regeneration and maintains chronically-denervated muscle to thereby promote motor re-innervation and functional recovery is supported.
Journal ArticleDOI
Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries
TL;DR: This work focuses on the use of adipose-tissue-derived stem cells and the possible mechanisms through which they may exert a positive influence on peripheral nerve regeneration, thereby enabling more effective nerve repair.
Journal ArticleDOI
A 3D-Printed Self-Adhesive Bandage with Drug Release for Peripheral Nerve Repair
Jiumeng Zhang,Yuwen Chen,Yulan Huang,Wenbi Wu,Xianming Deng,Haofan Liu,Rong Li,Jie Tao,Xiang Li,Xuesong Liu,Maling Gou +10 more
TL;DR: 3D‐printed self‐adhesive bandage designed that can form a wrap surrounding the injured nerve to promote nerve regeneration and recovery and has potential application in assisting the neurorrhaphy for nerve repair is used.
Journal ArticleDOI
Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth.
Georgios Baskozos,Oliver Sandy-Hindmarch,Alex J. Clark,Katherine Windsor,Páll Karlsson,Greg A. Weir,Greg A. Weir,Lucy A. McDermott,Joanna Burchall,Akira Wiberg,Dominic Furniss,David L.H. Bennett,Annina B. Schmid +12 more
TL;DR: Carpal tunnel release provides an opportunity to study sensory nerve regeneration in humans and ADCYAP1 (encoding PACAP) expression is associated with sensory reinnervation in vivo and facilitates neuron outgrowth in vitro.
Journal ArticleDOI
Characterising cellular and molecular features of human peripheral nerve degeneration
Matthew Wilcox,Matthew Wilcox,Simão Laranjeira,Tuula M. Eriksson,Kristjan R. Jessen,Rhona Mirsky,Tom Quick,Tom Quick,James B. Phillips +8 more
TL;DR: The down-regulation of c-Jun and p75NTR reported here provides the first molecular evidence that also in humans, repair cells deteriorate during chronic denervation, a process thought to be a major obstacle to effective nerve repair.
References
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Journal ArticleDOI
Exploring the full spectrum of macrophage activation.
TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
TL;DR: The authors would like to include as an addendum the contribution of R. Stout and J. Suttles to the conceptual framework of macrophage plasticity that was mentioned in the Review.
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