Journal ArticleDOI
Advances in peripheral nerve regeneration
Jami L. Scheib,Ahmet Hoke +1 more
TLDR
Use of rodent models of chronic denervation will facilitate the understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.Abstract:
Rodent models of nerve injury have increased our understanding of peripheral nerve regeneration, but clinical applications have been scarce, partly because such models do not adequately recapitulate the situation in humans. In human injuries, axons are often required to extend over much longer distances than in mice, and injury leaves distal nerve fibres and target tissues without axonal contact for extended amounts of time. Distal Schwann cells undergo atrophy owing to the lack of contact with proximal neurons, which results in reduced expression of neurotrophic growth factors, changes in the extracellular matrix and loss of Schwann cell basal lamina, all of which hamper axonal extension. Furthermore, atrophy and denervation-related changes in target tissues make good functional recovery difficult to achieve even when axons regenerate all the way to the target tissue. To improve functional outcomes in humans, strategies to increase the speed of axonal growth, maintain Schwann cells in a healthy, repair-capable state and keep target tissues receptive to reinnervation are needed. Use of rodent models of chronic denervation will facilitate our understanding of the molecular mechanisms of peripheral nerve regeneration and create the potential to test therapeutic advances.read more
Citations
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Journal ArticleDOI
Functional Electrical Stimulation and the Modulation of the Axon Regeneration Program.
TL;DR: Electrical stimulation-mediated neuroplasticity represents a therapeutically viable approach to support neural repair and recovery and will depend upon determining the underlying mechanisms of activity-dependent axon regeneration and the heterogeneity of neuronal subtype responses to stimulation.
Journal ArticleDOI
Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair.
Leyang Li,Hiroyuki Yokoyama,Hidetoshi Kaburagi,Takashi Hirai,Kunikazu Tsuji,Mitsuhiro Enomoto,Yoshiaki Wakabayashi,Atsushi Okawa +7 more
TL;DR: Motor axon denervation in the tibialis anterior muscle after peroneal nerve transection in thy1-YFP mice and regeneration with nerve reconstruction using allografts and Prevention of synaptic acetylcholine receptor degeneration may play a key role in peripheral nerve regeneration.
Journal ArticleDOI
Axonal regrowth is impaired during digit tip regeneration in mice.
Connor P. Dolan,Mingquan Yan,Katherine N. Zimmel,Tae-Jung Yang,Eric Leininger,Lindsay A. Dawson,Ken Muneoka,Ken Muneoka +7 more
TL;DR: Nerve regeneration is impaired in the context of mouse digit tip regeneration, and the central portion of the regenerating digit blastema is aneural, with axons and Schwann cells restricted to peripheral and distal blastema regions.
Journal ArticleDOI
Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury.
Benjamin R. Slavin,Benjamin R. Slavin,Karim A. Sarhane,Nicholas von Guionneau,Phillip J. Hanwright,Chenhu Qiu,Hai-Quan Mao,Ahmet Hoke,Sami H. Tuffaha +8 more
TL;DR: A review of the literature regarding the therapeutic potential of insulin-like growth factor-1 (IGF-1) in peripheral nerve injuries (PNIs) is presented in this article.
Posted ContentDOI
Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury
William Renthal,William Renthal,Ivan Tochitsky,Ivan Tochitsky,Lite Yang,Lite Yang,Lite Yang,Yung-Chih Cheng,Emmy Li,Riki Kawaguchi,Daniel H. Geschwind,Clifford J. Woolf,Clifford J. Woolf +12 more
TL;DR: By transcriptionally profiling sensory ganglia at single-cell resolution, it is found that different somatosensory neuronal subtypes undergo a remarkably consistent and dramatic transcriptional response to peripheral nerve injury that both promotes axonal regeneration and suppresses cell identity.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Erratum: Exploring the full spectrum of macrophage activation
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