Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions.
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TLDR
A review of the commonly used animal models to study SARS-CoV-2 and COVID-19, including a summary of their susceptibility to infection, the spectrum of symptoms elicited, and the potential for drug development in each model is provided in this paper.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2021-06-23 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Population.read more
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SARS-CoV-2 and Influenza A Virus Coinfections in Ferrets
TL;DR: In this paper , the authors examined the effect of coinfection ferret models described in this paper on the ability to prevent the most severe effects of viral coinfections and found that vaccination significantly ameliorated influenza-associated disease by protecting vaccinated animals from severe morbidity after IAV single infection or IAV and SARS-CoV-2 coinfectation.
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Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
Ravi Kant,Lauri Kareinen,Teemu Smura,Tobias L. Freitag,Sawan Kumar Jha,Kari Alitalo,Seppo Meri,Tarja Sironen,Kalle Saksela,Tomas Strandin,Anja Kipar,Anja Kipar,Anja Kipar,Olli Vapalahti +13 more
TL;DR: In this article, the SARS-CoV-2 beta variant attains infectibility to BALB/c mice and causes pulmonary changes within 2-3 days post infection, consistent with results seen in other murine models of COVID-19.
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RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection
TL;DR: In this article , the authors used the K18-hACE2 mouse model to examine whether activation of the antiviral RNA receptor RIG-I protects mice from lethal SARS-CoV-2 infection and reduces disease severity.
Posted ContentDOI
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection
Samira Marx,Beate M Kuemmerer,Christian Gruetzner,Hiroki Kato,Martin Schlee,Eva Bartok,Eva Bartok,Marcel Renn,Gunther Hartmann +8 more
TL;DR: Results reveal that prophylactic RIG-I activation by synthetic RNA oligonucleotides is a promising strategy to convey short-term, unspecific antiviral protection against SARS-CoV-2 infection and may be a suitable broad-spectrum approach to constraining the spread of newly emerging viruses until virus-specific therapies and vaccines become available.
Journal ArticleDOI
Animal models for studying COVID-19, prevention, and therapy: Pathology and disease phenotypes
TL;DR: An overview of commonly used COVID-19 animal models and the pathologic features of SARS-CoV-2 infection in these models in relation to their clinical presentation in humans is provided.
References
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Journal ArticleDOI
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Jing Sun,Zhen Zhuang,Jian Zheng,Kun Li,Roy Lok-Yin Wong,Donglan Liu,Jicheng Huang,Jiangping He,Airu Zhu,Jingxian Zhao,Xiaobo Li,Yin Xi,Rongchang Chen,Abeer N. Alshukairi,Zhao Chen,Zhaoyong Zhang,Chunke Chen,Xiaofang Huang,Fang Li,Xiaomin Lai,Dingbin Chen,Liyan Wen,Jianfen Zhuo,Yanjun Zhang,Yanqun Wang,Shuxiang Huang,Jun Dai,Yongxia Shi,Kui Zheng,Mariah R. Leidinger,Jiekai Chen,Yimin Li,Nanshan Zhong,David K. Meyerholz,Paul B. McCray,Stanley Perlman,Jincun Zhao +36 more
TL;DR: A murine model of broad and immediate utility is described to investigate COVID-19 pathogenesis, and to evaluate new therapies and vaccines.
Journal ArticleDOI
SARS-like WIV1-CoV poised for human emergence
Vineet D. Menachery,Boyd Yount,Amy C. Sims,Kari Debbink,Sudhakar Agnihothram,Lisa E. Gralinski,Rachel L. Graham,Trevor Scobey,Jessica A. Plante,Scott R. Royal,Jesica Swanstrom,Timothy P. Sheahan,Raymond J. Pickles,Raymond J. Pickles,Davide Corti,Scott H. Randell,Antonio Lanzavecchia,Wayne A. Marasco,Ralph S. Baric,Ralph S. Baric +19 more
TL;DR: An approach that combines existing metagenomics data with reverse genetics to engineer reagents to evaluate emergence and pathogenic potential of circulating zoonotic viruses indicates that the WIV1-coronavirus (CoV) cluster has the ability to directly infect and may undergo limited transmission in human populations.
Journal ArticleDOI
SARS-CoV-2 spike D614G change enhances replication and transmission.
Bin Zhou,Tran Thi Nhu Thao,Donata Hoffmann,Adriano Taddeo,Nadine Ebert,Fabien Labroussaa,Anne Pohlmann,Jacqueline King,Silvio Steiner,Jenna N. Kelly,Jasmine Portmann,Nico Joel Halwe,Lorenz Ulrich,Bettina Salome Trüeb,Xiaoyu Fan,Bernd Hoffmann,Li Wang,Lisa Thomann,Xudong Lin,Hanspeter Stalder,Berta Pozzi,Simone de Brot,Nannan Jiang,Dan Cui,Jaber Hossain,Malania M. Wilson,Matthew W. Keller,Thomas J. Stark,John R. Barnes,Ronald Dijkman,Joerg Jores,Charaf Benarafa,David E. Wentworth,Volker Thiel,Martin Beer +34 more
TL;DR: In this paper, the authors used isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme (ACE2) and increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model.
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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Jian Zheng,Lok-Yin Roy Wong,Kun Li,Abhishek Kumar Verma,M. Ortiz,Christine L. Wohlford-Lenane,Mariah R. Leidinger,C. Michael Knudson,David K. Meyerholz,Paul B. McCray,Stanley Perlman +10 more
TL;DR: Transgenic K18-hACE2 mice are a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions; infection of these mice resulted in severe pneumonia and, in some cases, infection in the brain, which was prevented by convalescent plasma.
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Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
Fan Jiang,Jianmin Yang,Yongtao Zhang,Mei Dong,Shuangxi Wang,Qunye Zhang,Fang Fang Liu,Kai Zhang,Cheng Zhang +8 more
TL;DR: The ACE2-mediated catabolism of angiotensin II is likely to have a major role in cardiovascular protection, whereas the relevant functions and signalling mechanisms of actions induced by ang Elliotensin 1–7 have not been conclusively determined.