Antiviral activities of type I interferons to SARS-CoV-2 infection.
TLDR
The sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β) is reported and the potential efficacy of human Type I IFN in suppressing Sars- CoV- 2 infection is demonstrated, which could inform future treatment options for COVID-19.About:
This article is published in Antiviral Research.The article was published on 2020-07-01 and is currently open access. It has received 345 citations till now. The article focuses on the topics: Vero cell.read more
Citations
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Characteristics of SARS-CoV-2 and COVID-19
TL;DR: The basic virology of SARS-CoV-2 is described, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses.
Journal ArticleDOI
Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.
Journal ArticleDOI
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.
TL;DR: The recent progress in the understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses is described and the potential use of IFNs as a treatment strategy for COVID-19 is discussed.
Journal ArticleDOI
Evasion of Type I Interferon by SARS-CoV-2.
Hongjie Xia,Zengguo Cao,Xuping Xie,Xianwen Zhang,John Yun Chung Chen,Hualei Wang,Vineet D. Menachery,Ricardo Rajsbaum,Pei Yong Shi +8 more
TL;DR: Insight is provided on SARS-CoV-2 evasion of IFN-I response and its potential impact on viral transmission and pathogenesis.
Journal ArticleDOI
Interplay between SARS-CoV-2 and the type I interferon response.
TL;DR: The potential benefits of a well-timed IFN-I treatment and strategies to boost pDC-mediated IFN responses during the early stages of viral infection are discussed.
References
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A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
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TL;DR: This review summarizes the history of the purification of human IFNs and the key aspects of the current state of knowledge of humanIFN genes, proteins, and receptors and provides some new insights into the development of these proteins as major elements of innate immunity.
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