Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway
TL;DR: Wang et al. as mentioned in this paper showed that senescent fibroblasts displayed CAF properties, including the highly expressed CAF markers, α-SMA and Vimentin, and CAF-specific factors, CXCL12, FGF10, IL6 and COL1A1, which significantly increased collagen contractile activity and promoted the migration and invasion of lung cancer cells, H1299 and A549.
Journal ArticleDOI
Exosomal microRNAs mediating crosstalk between cancer cells and cancer-associated fibroblasts in the tumor microenvironment.
TL;DR: A comprehensive search of the literature was conducted through PubMed databases as discussed by the authors , which provided information about articles published in peer-reviewed journals until 2022, including exosomes, cancer-associated fibroblasts, microRNA and cancer.
Book ChapterDOI
Molecular approaches toward targeted cancer therapy with some food plant products: On the role of antioxidants and immune microenvironment
TL;DR: This review summarizes the current knowledge of DDR and immune microenvironment in therapeutic cancer research and role of some food plants and their phytochemicals as antioxidants in targeted cancer therapy.
Journal ArticleDOI
Tumorous CD10 Is More Strongly Related to the Progression of Urothelial Carcinoma than Stromal CD10.
Arisa Kumagai-Togashi,Hiroshi Uozaki,Yoshinao Kikuchi,Shiori Watabe,Satoe Numakura,Masato Watanabe +5 more
TL;DR: Tumorous CD10 is more strongly related to progression of UC than stromal CD10 and is an independent factor for UC prognosis, while miR-21 expression in TCs and TS were independent prognostic factors.
Journal ArticleDOI
The effect of tranilast on fibroblast activation protein α (FAP-α) expression in normal and keloid fibroblasts in vitro
Paweł P. Antończak,Magdalena Jurzak,Katarzyna Adamczyk,Agnieszka Garncarczyk,Magdalena Hartman-Petrycka +4 more
TL;DR: Tranilast antiproliferative effect is not associated with FAP-α expression in keloid fibroblasts, and fibroblast activation protein α (FAP- α) may play an important role in remodeling of extracellular matrix and the invasive properties of keloids.
References
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