Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes.
TL;DR: The diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, are explored, particularly in the context of cancer immunoediting.
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Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks.
Yang Wang,Kazuki Takeishi,Zhao Li,Eduardo Cervantes-Alvarez,Alexandra Collin de l'Hortet,Jorge Guzman-Lepe,Xiao Cui,Ji-ye Zhu +7 more
TL;DR: It is demonstrated that hepatocellular carcinoma (HCC) cells, fibroblasts, endothelial cells and extracellular matrix can generate organoid-like spheroids that enhanced numerous features of human HCC observed in vivo.
Journal ArticleDOI
Significance of stroma in biology of oral squamous cell carcinoma
Vanja Vučićević Boras,Aleksandra Fučić,Mihajlo Virag,Dragana Gabrić,Igor Blivajs,Cedna Tomasovic-Loncaric,Zoran Rakušić,Vesna Bišof,Nicolas Le Novère,Danko Velimir Vrdoljak +9 more
TL;DR: The aim of this review is to provide an insight into the factors that activate OSCC stroma and hence faciliate neoplastic progression and enable the more efficient recognition of possible new biomarkers in the diagnostics and follow-up of OSCC or in finding new therapeutic targets.
Journal ArticleDOI
Annexin A1 as a Regulator of Immune Response in Cancer
Thaise Gonçalves Araújo,Sara Teixeira Soares Mota,Helen Soares Valença Ferreira,Matheus Alves Ribeiro,Luiz Ricardo Goulart,Lara Vecchi +5 more
TL;DR: In this article, the role of Annexin A1 in the establishment of the tumor microenvironment, focusing on the immunosuppressive and immunomodulatory activities of AnxA1 and on its interaction with the epidermal growth factor receptor.
Journal ArticleDOI
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy.
TL;DR: Recent progress and challenges of nanomaterials used to modulate the TME to enhance the efficacy of anticancer chemotherapy and immunotherapy are summarized.
References
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Journal ArticleDOI
The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.