Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
Citations
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Journal ArticleDOI
Isolation of Fibroblast-Activation Protein-Specific Cancer-Associated Fibroblasts.
Yingying Huang,Sufang Zhou,Yong Huang,Duo Zheng,Qiqi Mao,Jian He,Yiwei Wang,Dabing Xue,Xiaoling Lu,Nuo Yang,Yongxiang Zhao +10 more
TL;DR: The fibroblasts isolated by the innovation are with high purity and being in wonderful condition and display the features of CAFs.
Journal ArticleDOI
Chemotherapy resistance and stromal targets in breast cancer treatment: a review.
TL;DR: Within the scope of personalized treatment, biomarkers based on the tumor–stroma have future potential for the improvement of treatment via image-guided surgery (IGS) and PET scanning and the available literature is limited.
Book ChapterDOI
Stimulus-responsive gold nanotheranostic platforms for targeting the tumor microenvironment
TL;DR: This chapter highlights the physiology of tumor and tumor microenvironment, nanotheranostics, and several types of gold nanosystems developed as nanotherANostics, with a special emphasis on the effect of various stimuli on AuNPs for diagnosis and treatment of cancer.
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ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance
TL;DR: An improved in vitro model formed by growing A549 cells and human fibroblasts as an ALI multilayered co-culture opens new research avenues for the development of alternatives to animal-based inhalation studies, impacting theDevelopment of anti-NSCLC drugs.
Journal ArticleDOI
circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway
Shangyou Zheng,Chonghui Hu,Hongcao Lin,Guolin Li,Renpeng Xia,Xiang Zhang,Dan Su,Zhihua Li,Quanbo Zhou,Rufu Chen +9 more
TL;DR: In this article , the effect of circCUL2 on inflammatory cancer-associated fibroblasts (iCAF) activation, heterogeneity and protumor activity by ELISA, flow cytometry, colony formation and transwell assays in vitro and by xenograft models in vivo was examined by RNA pulldown, FISH and luciferase reporter assays.
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