Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
Citations
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Mechanoregulation of Cancer-Associated Fibroblast Phenotype in Three-Dimensional Interpenetrating Hydrogel Networks.
TL;DR: The results revealed that the 3D polymeric network mechanics and microstructure are critical biophysical determinants of the human breast CAF (b-CAF) morphology, phenotype, and paracrine dialogue with MDA-MB-231 tumoroids.
Journal ArticleDOI
Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites
TL;DR: This proof of concept study demonstrates that DNAm analysis at individual CpGs reflects the cellular composition of cellular mixtures and different tissues.
Journal ArticleDOI
MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner.
Francesca Andriani,Maria Teresa Majorini,Miguel Mano,Miguel Mano,Elena Landoni,Rosalba Miceli,Federica Facchinetti,Mavis Mensah,Enrico Fontanella,Matteo Dugo,Mauro Giacca,Ugo Pastorino,Gabriella Sozzi,Domenico Delia,Luca Roz,Daniele Lecis +15 more
TL;DR: It is found that primary fibroblast cell lines derived from lungs of heavy smokers express reduced miR-16 levels compared to those from lungs not exposed to smoke and that HGF concentration in heavy smokers’ plasma correlates with levels of tobacco exposure.
Journal ArticleDOI
Emerging insights into the biology of metastasis: A review article.
TL;DR: Cancer metastasis is critical factor to predict survival in patients with advanced cancer and prognosis determines the treatment plan, and increasing knowledge about the mechanism can help in finding the promising targets of cancer therapy.
Journal ArticleDOI
Interferon-γ and Colorectal Cancer: an up-to date
Christoforos Kosmidis,Konstantinos Sapalidis,Triantafyllia Koletsa,Maria Kosmidou,Christoforos Efthimiadis,George Anthimidis,Nikolaos Varsamis,Nikolaos V. Michalopoulos,Charilaos Koulouris,Stefanos Atmatzidis,Lazaros Liavas,Titika-Marina Strati,Georgios Koimtzis,Alexandros Tsakalidis,Stylianos Mantalovas,Katerina Zarampouka,Maria Florou,Dimitrios Giannakidis,Eleni Georgakoudi,Sofia Baka,Paul Zarogoulidis,Yan-Gao Man,Isaac Kesisoglou +22 more
TL;DR: The microenvironment is very important for the successful delivery of the treatment and several proteins and hormones play a crucial role in the efficiency of the Treatment.
References
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