Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
Citations
More filters
Journal ArticleDOI
Advancement and Future Perspective of FAPI PET/CT In Gynecological Malignancies.
Katharina Dendl,Stefan A. Koerber,Katharina Tamburini,Yuriko Mori,Jens Cardinale,Uwe Haberkorn,Frederik L. Giesel +6 more
TL;DR: Preliminary findings suggest that gynecological cancers seem to represent a field of interest for the utilization of FAPI-PET/CT to potentially improve staging, restaging and therapeutic management.
Journal ArticleDOI
Cancer-associated fibroblasts (CAFs) in thyroid papillary carcinoma: molecular networks and interactions.
TL;DR: In this article, a review summarises the clinical presentation of current knowledge of classical papillary thyroid carcinoma (PTC), emerging molecular diagnostics and future directions of classical PTC research.
Estudios Moleculares y Celulares del Sistema de Endotelinas en Cáncer Colorectal
TL;DR: Las evidencias morfologicas obtenidas en los animales normales y los inducidos al desarrollo tumoral, se correlacionaron with indices de auto-fluorescencia obtenidos por microscopia de desconvolucion digital; el cual fue determinado registrando la fluorescencia endogena proveniente of the superficie epitelial del colon.
Journal ArticleDOI
Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend
Mehdi Karimi-Shahri,Hossein Javid,Alireza Sharbaf Mashhad,Shaghayegh Yazdani,Seyed Isaac Hashemy +4 more
TL;DR: This review was arranged to provide a comprehensive and precise description of MSCs’ role in regulating tumorigenesis and to discuss the dark and the bright sides of cancer treatment strategies using MSCS.
Journal ArticleDOI
Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors.
Ramesh Mukkamala,Spencer D. Lindeman,Kate A Kragness,Imrul Shahriar,Madduri Srinivasarao,Philip S. Low +5 more
TL;DR: It is concluded that FTL-S-S0456 constitutes an excellent ligand-targeted near infrared dye that enables intra-operative imaging of most if not all solid tumors.
References
More filters
Journal ArticleDOI
The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.