Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
Citations
More filters
Journal ArticleDOI
Targeting the tumour stroma to improve cancer therapy
TL;DR: An overview of the advances in understanding the complex cancer cell–tumour stroma interactions is provided and how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes are discussed.
Journal ArticleDOI
Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
TL;DR: This review article summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones, which it believes offer a good chance for the practical translation of nanoparticle formulas into clinic.
Journal ArticleDOI
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
TL;DR: The key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses are considered, which highlight the potential of targeting IL- 6 family members to treat inflammatory diseases and cancer.
Book ChapterDOI
Tumor-Derived Exosomes and Their Role in Cancer Progression.
TL;DR: Tumor-derived exosomes may interfere with cancer immunotherapy, but they also could serve as adjuvants and antigenic components of antitumor vaccines and are of potential interest as noninvasive biomarkers of cancer.
Journal ArticleDOI
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
Reuben Moncada,Dalia Barkley,Florian Wagner,Marta Chiodin,Joseph C. Devlin,Maayan Baron,Cristina H. Hajdu,Diane M. Simeone,Itai Yanai +8 more
TL;DR: Applying multimodal intersection analysis to primary pancreatic tumors, it is found that subpopulations of ductal cells, macrophages, dendritic cells and cancer cells have spatially restricted enrichments, as well as distinct coenrichments with other cell types.
References
More filters
Journal ArticleDOI
Effects of cancer-associated fibroblasts on the migration and invasion abilities of SGC-7901 gastric cancer cells.
Cheng-Yi Hu,Zheng-Cai Wang,Lili Zhai,Miling Yang,Lihui Shan,Cuicui Chai,Ming Liu,Li-Feng Wang +7 more
TL;DR: The interactions of CAFs and the extracellular matrix with S GC-7901 cells may significantly increase the migration and invasion abilities of SGC- 7901 cells.
Journal Article
Prognostic role of vascular endothelial growth factor in prostate cancer: a systematic review and meta-analysis
TL;DR: It is demonstrated that VEGF may have a critical prognostic value in patients with prostatic cancer and its hazard ratio and its 95% confidence interval were used to assess the strength of associations.
Journal ArticleDOI
Vascular endothelial growth factor-A and -C: expression and correlations with lymphatic metastasis and prognosis in colorectal cancer
TL;DR: Increased expression of VEGF-A and VEGf-C in marginal portion of colorectal cancer was correlated with lymph node metastasis, and different mechanisms may exist in the invasion of tumor cells into peritumoral and intratumoral lymphatic vessels.
Journal ArticleDOI
A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer
Abdel Hosein,Abdel Hosein,Julie Livingstone,Marguerite Buchanan,James F Reid,Michael Hallett,Mark Basik +6 more
TL;DR: Primary breast CAFs show inter-patient molecular heterogeneity as evidenced by interferon response gene elements activated in a subgroup of CAFs, which result in paracrine pro-proliferative effects in a breast cancer cell line co-culture model.
Journal ArticleDOI
Cancer-associated fibroblasts in a human HEp-2 established laryngeal xenografted tumor are not derived from cancer cells through epithelial-mesenchymal transition, phenotypically activated but karyotypically normal.
TL;DR: The findings reveal that the CAFs in the HEp-2 established laryngeal xenografted tumor are not of laryngeyal cancer origin but of mouse origin, indicating that the HEP-2 larynGEal cancer cells cannot generate their own CAFs via EMT in this model.