Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles
Rahul Bhome,Muhammad Emaduddin,Victoria James,Louise M. House,Stephen M. Thirdborough,Massimiliano Mellone,Joeri Tulkens,John N. Primrose,Gareth J. Thomas,Olivier De Wever,Alex H. Mirnezami,A. Emre Sayan +11 more
TL;DR: Data provide a new mechanism for the development of fibroblast heterogeneity in CRC, through EV‐mediated transfer of miRNAs, and provide an explanation as to why CRC tumours with greater metastatic potential are CAF rich.
Journal ArticleDOI
Emerging role of tumor microenvironment derived exosomes in therapeutic resistance and metastasis through epithelial-to-mesenchymal transition
TL;DR: In this article, molecular signatures of exosomes that shuttle between cancer cells and their stromal populations in tumor microenvironment were analyzed to explicate their impact on therapeutic resistance and metastasis through EMT.
Journal ArticleDOI
Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells, Obesity and the Tumor Microenvironment of Breast Cancer
Andreas Ritter,Nina-Naomi Kreis,Samira Catharina Hoock,Christine Solbach,Frank Louwen,Juping Yuan +5 more
TL;DR: In this paper , the authors have addressed the impact of obesity on ASCs/MSCs, summarized the crosstalk between ASCs and breast cancer cells, discussed related molecular mechanisms, and highlighted related research perspectives.
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A Dual Fluorescent 3-D Multicellular Coculture of Breast Cancer MCF-7 and Fibroblast NIH-3T3 Cells for High Throughput Cancer Drug Screening
Xin Xin,Shang-Tian Yang +1 more
TL;DR: The dual fluorescence 3D coculture assay can provide a reliable high throughput platform for screening cancer drugs whose efficacy may be impacted by fibroblasts in tumor stroma.
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Precision pathology analysis of the development and progression of hepatocellular carcinoma: Implication for precision diagnosis of hepatocellular carcinoma.
Akihisa Ueno,Yohei Masugi,Ken Yamazaki,Yutaka Kurebayashi,Hanako Tsujikawa,Kathryn Effendi,Hidenori Ojima,Michiie Sakamoto +7 more
TL;DR: An overview of how pathological analysis contributes to understanding the development and progression of HCC and establishing a precision diagnosis is given.
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