Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth.
Kazuyoshi Shiga,Masayasu Hara,Takaya Nagasaki,Takafumi Sato,Hiroki Takahashi,Hiromitsu Takeyama +5 more
TLDR
It is shown that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions, and CAFs contribute to drug-resistance acquisition in cancer cells.Abstract:
Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer have focused on alterations in cancer cells, including genetic and epigenetic changes. Recently, interactions between cancer cells and the stroma have attracted considerable attention, and increasing evidence has accumulated on this. Several researchers have gradually clarified the origins, features, and roles of cancer-associated fibroblasts (CAFs), a major component of the cancer stroma. CAFs function in a similar manner to myofibroblasts during wound healing. We previously reported the relationship between CAFs and angiogenesis. Interleukin-6 (IL-6), a multifunctional cytokine, plays a central role in regulating inflammatory and immune responses, and important roles in the progression, including proliferation, migration, and angiogenesis, of several cancers. We showed that CAFs are an important IL-6 source and that anti-IL-6 receptor antibody suppressed angiogenesis and inhibited tumor-stroma interactions. Furthermore, CAFs contribute to drug-resistance acquisition in cancer cells. The interaction between cancer cells and the stroma could be a potential target for anti-cancer therapy.read more
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Cancer-Associated Fibroblasts as Players in Cancer Development and Progression and Their Role in Targeted Radionuclide Imaging and Therapy
Sofia Koustoulidou,Mark W. H. Hoorens,Simone U. Dalm,Shweta Mahajan,Reno Debets,Yann Seimbille,Marion de Jong +6 more
TL;DR: In this article, the authors summarized the current knowledge of the functional heterogeneity and biology of CAFs in cancer and highlighted the latest developments towards theranostic applications that will help tumour characterization, radioligand therapy and staging in cancers with a distinct CAF population.
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Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response:
Seung Il Kim,Sarah Choung,Ren X. Sun,Nolan Ung,Natasha Hashemi,Emma J. Fong,Roy Lau,Erin Spiller,Jordan Gasho,Jasmine Foo,Shannon M. Mumenthaler +10 more
TL;DR: This work examined tumor cell growth rates and drug response behaviors in colorectal cancer (CRC) PDTOs using dynamic confocal live cell imaging and data analysis methods and found a strong correlation between organoid live cell number and volume.
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A Co-Culture System of Three-Dimensional Tumor-Associated Macrophages and Three-Dimensional Cancer-Associated Fibroblasts Combined with Biomolecule Release for Cancer Cell Migration
TL;DR: This model is a promising 3D culture system to evaluate the invasion ability of various cancer cells in vitro and indicates that the epithelial-mesenchymal transition event was induced.
Journal ArticleDOI
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.
Hiroki Sakamoto,Yu-ichiro Koma,Nobuhide Higashino,Takayuki Kodama,Kohei Tanigawa,Masaki Shimizu,Masataka Fujikawa,Mari Nishio,Manabu Shigeoka,Yoshihiro Kakeji,Hiroshi Yokozaki +10 more
TL;DR: It is shown that plasminogen activator inhibitor-1 derived from cancer-associated fibroblasts promotes the invasion of esophageal squamous cell carcinoma (ESCC) cells and the migration of macrophages via lipoprotein receptor-related protein 1 (LRP1).
Journal ArticleDOI
DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment
Pauline Mathot,Mélodie Grandin,Guillaume Devailly,Frédérique Souazé,Vincent Cahais,Sebastian Moran,Mario Campone,Zdenko Herceg,Manel Esteller,Manel Esteller,Philippe Juin,Patrick Mehlen,Robert Dante +12 more
TL;DR: These data elucidate the importance of epigenetics marks in the cancer cell reprogramming induced by stromal cell and indicated that the interpreters of the DNA methylation signal have a major role in the response of the cancer cells to the microenvironment.
References
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Journal ArticleDOI
The biology of vascular endothelial growth factor
TL;DR: The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult.
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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.